公开(公告)号：DE69724422T2

公开(公告)日：2004-03-11

申请号：DE69724422

申请日：1997-05-12

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： JARROTT BEVYN ,  BEART MARK ,  JACKSON ROY ,  KENCHE BHASKAR ,  ROBERTSON DUNCAN ,  COLLIS PATRICIA

IPC: C07D295/04 ,  A61K31/00 ,  A61K31/34 ,  A61K31/343 ,  A61K31/357 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P25/04 ,  A61P25/18 ,  A61P39/00 ,  A61P39/06 ,  A61P43/00 ,  C07D209/12 ,  C07D213/30 ,  C07D213/38 ,  C07D295/08 ,  C07D295/084 ,  C07D295/18 ,  C07D295/185 ,  C07D307/81 ,  C07D311/58 ,  C07D311/72 ,  C07D317/58 ,  C07D333/28 ,  C07D333/54 ,  C07D405/12 ,  C07D409/12 ,  C07D209/14 ,  C07D295/096 ,  C07D295/192 ,  C07D311/66

Abstract: Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R1 is hydroxy; R2 and R3 are the same or different and are independently selected from hydrogen or C1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.

公开(公告)号：DE69724422D1

公开(公告)日：2003-10-02

申请号：DE69724422

申请日：1997-05-12

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： JARROTT BEVYN ,  BEART MARK ,  JACKSON ROY ,  KENCHE BHASKAR ,  ROBERTSON DUNCAN ,  COLLIS PATRICIA

IPC: C07D295/04 ,  A61K31/00 ,  A61K31/34 ,  A61K31/343 ,  A61K31/357 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P25/04 ,  A61P25/18 ,  A61P39/00 ,  A61P39/06 ,  A61P43/00 ,  C07D209/12 ,  C07D213/30 ,  C07D213/38 ,  C07D295/08 ,  C07D295/084 ,  C07D295/18 ,  C07D295/185 ,  C07D307/81 ,  C07D311/58 ,  C07D311/72 ,  C07D317/58 ,  C07D333/28 ,  C07D333/54 ,  C07D405/12 ,  C07D409/12 ,  C07D209/14 ,  C07D295/096 ,  C07D295/192 ,  C07D311/66

Abstract: Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R1 is hydroxy; R2 and R3 are the same or different and are independently selected from hydrogen or C1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.