公开(公告)号：DE60215195T2

公开(公告)日：2007-08-23

申请号：DE60215195

申请日：2002-08-09

Applicant: MONASH UNIVERSITY CLAYTON ,  NEURO THERAPEUTICS LTD

Inventor： JACKSON ROY ,  SUBASINGHE RUPIKA

IPC: C07D489/02 ,  A61K31/485 ,  A61K47/48 ,  A61P25/04 ,  C07D211/32 ,  C07D211/64 ,  C07D221/26 ,  C07D221/28 ,  C07D223/06 ,  C07D223/14 ,  C07D489/04 ,  C07D489/12 ,  C07F7/18

Abstract: The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of compounds according to formula (I), pharmaceutical or veterinary compositions containing such compounds or methods of treatment and/or prophylaxis of a condition or symptom that is inhibited, reduced or alleviated by opioid receptor activation

公开(公告)号：DE69724422T2

公开(公告)日：2004-03-11

申请号：DE69724422

申请日：1997-05-12

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： JARROTT BEVYN ,  BEART MARK ,  JACKSON ROY ,  KENCHE BHASKAR ,  ROBERTSON DUNCAN ,  COLLIS PATRICIA

IPC: C07D295/04 ,  A61K31/00 ,  A61K31/34 ,  A61K31/343 ,  A61K31/357 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P25/04 ,  A61P25/18 ,  A61P39/00 ,  A61P39/06 ,  A61P43/00 ,  C07D209/12 ,  C07D213/30 ,  C07D213/38 ,  C07D295/08 ,  C07D295/084 ,  C07D295/18 ,  C07D295/185 ,  C07D307/81 ,  C07D311/58 ,  C07D311/72 ,  C07D317/58 ,  C07D333/28 ,  C07D333/54 ,  C07D405/12 ,  C07D409/12 ,  C07D209/14 ,  C07D295/096 ,  C07D295/192 ,  C07D311/66

Abstract: Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R1 is hydroxy; R2 and R3 are the same or different and are independently selected from hydrogen or C1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.

公开(公告)号：DE60215195D1

公开(公告)日：2006-11-16

申请号：DE60215195

申请日：2002-08-09

Applicant: MONASH UNIVERSITY CLAYTON ,  NEURO THERAPEUTICS LTD

Inventor： JACKSON ROY ,  SUBASINGHE RUPIKA

IPC: C07D489/02 ,  A61K31/485 ,  A61K47/48 ,  A61P25/04 ,  C07D211/32 ,  C07D211/64 ,  C07D221/26 ,  C07D221/28 ,  C07D223/06 ,  C07D223/14 ,  C07D489/04 ,  C07D489/12 ,  C07F7/18

Abstract: The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of compounds according to formula (I), pharmaceutical or veterinary compositions containing such compounds or methods of treatment and/or prophylaxis of a condition or symptom that is inhibited, reduced or alleviated by opioid receptor activation

公开(公告)号：DE69724422D1

公开(公告)日：2003-10-02

申请号：DE69724422

申请日：1997-05-12

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： JARROTT BEVYN ,  BEART MARK ,  JACKSON ROY ,  KENCHE BHASKAR ,  ROBERTSON DUNCAN ,  COLLIS PATRICIA

IPC: C07D295/04 ,  A61K31/00 ,  A61K31/34 ,  A61K31/343 ,  A61K31/357 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P25/04 ,  A61P25/18 ,  A61P39/00 ,  A61P39/06 ,  A61P43/00 ,  C07D209/12 ,  C07D213/30 ,  C07D213/38 ,  C07D295/08 ,  C07D295/084 ,  C07D295/18 ,  C07D295/185 ,  C07D307/81 ,  C07D311/58 ,  C07D311/72 ,  C07D317/58 ,  C07D333/28 ,  C07D333/54 ,  C07D405/12 ,  C07D409/12 ,  C07D209/14 ,  C07D295/096 ,  C07D295/192 ,  C07D311/66

Abstract: Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R1 is hydroxy; R2 and R3 are the same or different and are independently selected from hydrogen or C1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.