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1.发明申请IDENTIFICATION OF NATURAL SMALL-MOLECULES AMPK ACTIVATORS FOR TREATMENT OF CANCERS OR MULTIDRUG-RESISTANT CANCERS 有权鉴定自然小分子AMPK激活剂治疗癌症或多重耐药性癌症公开(公告)号：US20170056390A1
公开(公告)日：2017-03-02
申请号：US14925962
申请日：2015-10-28
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Liang LIU
IPC: A61K31/4745
CPC classification number: A61K31/4745
Abstract: The present invention discloses a method of treating cancer and/or multidrug-resistant cancer, comprising administering an effective amount of hernandezine or thalidezine. A pharmaceutical composition comprising hernandezine or thalidezine admixed with a pharmaceutical carrier for treating cancers and/or multidrug-resistant cancer is also disclosed.
Abstract translation: 本发明公开了一种治疗癌症和/或多药耐药性癌症的方法，其包括施用有效量的涕灭威或沙利度胺。 还公开了包含与用于治疗癌症和/或多药耐药性癌症的药物载体混合的栀子苷或沙利度胺的药物组合物。
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2.发明申请PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE DOSE OF POMIFERIN FOR TREATING CANCERS 审中-公开包含POMIFININ治疗癌症有效剂量的药物组合物公开(公告)号：US20170014375A1
公开(公告)日：2017-01-19
申请号：US14799541
申请日：2015-07-14
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Liang LIU , Su-Wei XU
IPC: A61K31/352
CPC classification number: A61K31/352
Abstract: The present invention provides a compound of formula (I) as a SERCA inhibitor for treating cancers, a pharmaceutical composition comprising said compound, and methods of using said compound for treating cancers and/or inducing cell death in cells of said cancers. Said cancers include but not limited to cervical, lung, liver, breast, and prostate cancer. Said cancers also include drug-resistant and/or apoptosis-resistant cancers such as isogenic drug-resistant colon cancer. The subject being administered with said compound or the composition comprising thereof can be human or animal subject. Said methods for treating cancers and/or inducing cell death can be a targeting treatment for certain cancers.
Abstract translation: 本发明提供了作为用于治疗癌症的SERCA抑制剂的式（I）化合物，包含所述化合物的药物组合物，以及使用所述化合物治疗癌症和/或诱导所述癌症细胞中的细胞死亡的方法。 所述癌症包括但不限于宫颈癌，肺癌，肝癌，乳腺癌和前列腺癌。 所述癌症还包括耐药性和/或细胞凋亡抵抗性癌症，例如同基因耐药结肠癌。 给予所述化合物或包含其的组合物的受试者可以是人或动物受试者。 用于治疗癌症和/或诱导细胞死亡的所述方法可以是某些癌症的靶向治疗。
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公开(公告)号：US20160106733A1
公开(公告)日：2016-04-21
申请号：US14985419
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Liang LIU , Jingrong WANG
IPC: A61K31/4748 , A61K31/4725
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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4.发明申请N-desmethyldauricine, A Novel Autophagic Enhancer for Treatment of Cancers and Neurodegenerative Conditions Thereof 审中-公开N-去甲基牛磺酸，一种用于治疗癌症和神经变性疾病的新型自噬增强剂公开(公告)号：US20150133492A1
公开(公告)日：2015-05-14
申请号：US14526539
申请日：2014-10-29
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Zhi Hong JIANG , Liang LIU , Wai Kit CHAN , Xiao Jun YAO
IPC: A61K31/4725
CPC classification number: A61K31/4725
Abstract: This invention is directed to the use of N-desmethyldauricine, a novel autophagy enhancer, in treating cancers or neurodegenerative conditions.
Abstract translation: 本发明涉及一种新型自噬增强剂N-去甲基牛磺酸在治疗癌症或神经变性疾病中的应用。
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公开(公告)号：US20160113922A1
公开(公告)日：2016-04-28
申请号：US14985417
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Liang LIU , Jingrong WANG
IPC: A61K31/4745 , A61K31/4725
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20160106732A1
公开(公告)日：2016-04-21
申请号：US14985412
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Liang LIU , Jingrong WANG
IPC: A61K31/4748 , A61K31/4725
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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公开(公告)号：US20150050363A1
公开(公告)日：2015-02-19
申请号：US14231671
申请日：2014-03-31
Applicant: Macau University of Science and Technology
Inventor： Yuen Kwan LAW , An Guo WU , Kam Wai WONG , Liang LIU
IPC: A61K36/69
CPC classification number: A61K36/69 , A61K31/704
Abstract: Use and application of Onjisaponin B derived and isolated from Radix Polygalae as novel autophagy enhancer are provided. A method of preventing, treating and/or delaying the onset of neurodegenerative diseases comprising administering an effective amount of Onjisaponin B is also provided.
Abstract translation: 本发明提供了从根部提取和分离的Onjisaponin B作为新的自噬增强剂的应用和应用。 还提供了预防，治疗和/或延缓神经变性疾病发作的方法，包括给予有效量的Onjisaponin B.
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公开(公告)号：US20160106730A1
公开(公告)日：2016-04-21
申请号：US14985414
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Liang LIU , Jingrong WANG
IPC: A61K31/4725
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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9.发明申请Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions Thereof 审中-公开生物碱组，用于治疗癌症和神经变性疾病的新型自噬增强剂公开(公告)号：US20150190392A1
公开(公告)日：2015-07-09
申请号：US14562781
申请日：2014-12-08
Applicant: Macau University of Science and Technology
Inventor： Kam Wai WONG , Yuen Kwan LAW , Liang LIU , Jingrong WANG
IPC: A61K31/4745 , A61K31/4725
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
Abstract translation: 本发明公开了一种治疗癌症的方法，该方法包括给予有效量的生物碱，其中生物碱为留丝氨酸，依沙星碱，屈酸，去甲肾上腺素，栀子或沙利度胺，并从中药中分离出来。 还公开了使用生物碱治疗神经变性疾病。
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公开(公告)号：US20150164885A1
公开(公告)日：2015-06-18
申请号：US14562780
申请日：2014-12-08
Applicant: Macau University of Science and Technology
Inventor： Yuen Kwan LAW , Kam Wai WONG , Liang LIU
IPC: A61K31/4725 , A61K36/185
CPC classification number: A61K31/4725 , A61K36/62
Abstract: The present invention discloses a method of treating neurodegenerative disorder comprising administering an effective amount of an alkaloid which is a bisbenzylisoquinline alkaloid isolated from the traditional Chinese medicinal herb Nelumbo nucifera. The pharmaceutical composition thereof for treating Huntington's disease is also disclosed.
Abstract translation: 本发明公开了一种治疗神经变性疾病的方法，包括给予有效量的生物碱，所述生物碱是从中草药Nelumbo Nucumera分离的双苄基异喹啉生物碱。 还公开了其用于治疗亨廷顿病的药物组合物。
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