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公开(公告)号：WO2014100732A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/077252
申请日：2013-12-20
Applicant: MICRONICS, INC.
Inventor： KOLB, Andrew , SPRAGUE, Isaac , KAY, Justin, L. , BRAGD, Matthew, Scott , STONE, Martha
IPC: F15C3/04
CPC classification number: B01L3/50273 , B01L3/502707 , B01L3/502738 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B29C43/021 , B29C65/16 , B29K2101/00 , B29L2009/00 , B29L2031/7496 , B81B2201/052 , B81C1/00119 , F04B43/043 , F16K99/0015 , F16K99/0059 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , Y10T156/1026
Abstract: Fluidic cartridges, and manufacture thereof, having a plurality of circuit element subtypes containing pneumatically operated diaphragm members, where the diaphragm materials are selected for yield point, chemical resistance, breathability and other properties individually according to the fluidic element subtype are provided. A process of in-situ edge-bonded decoupage for forming diaphragm members inside a cartridge, and fluidic circuits having diaphragm members as active and passive circuit elements, including pumps, valves, vents, waste receptacles, reagent reservoirs, and cuvettes with optical windows, where the material composition of each individual diaphragm member may be selected from an assortment of materials during manufacture are also provided.
Abstract translation: 提供具有包含气动操作的隔膜部件的多个电路元件亚型的流体盒及其制造，其中根据流体元件亚型分别选择隔膜材料用于屈服点，耐化学性，透气性和其它性质。 一种用于在筒内形成膜片构件的原位边缘粘合去耦的过程，以及具有作为主动和被动电路元件的隔膜构件的流体回路，包括泵，阀，通风口，废物容器，试剂储存器和具有光学窗口的比色杯， 其中还提供了每个单独隔膜构件的材料组成可以在制造期间从各种材料中选择。
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2.发明申请MICROFLUIDIC CARTRIDGES AND APPARATUS WITH INTEGRATED ASSAY CONTROLS FOR ANALYSIS OF NUCLEIC ACIDS 审中-公开具有集成测量控制的微流控盒和装置用于分析核酸
公开(公告)号：WO2015191916A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035419
申请日：2015-06-11
Applicant: MICRONICS, INC. , HOFFMAN, Danny , BERGDAHL, Asa , COUCH, Megan , RIVERA, Raf , BRAGD, Matthew Scott
Inventor： HOFFMAN, Danny , BERGDAHL, Asa , COUCH, Megan , RIVERA, Raf , BRAGD, Matthew Scott , LOFQUIST, Alan, K. , KOLB, Andrew , KAY, Justin, L.
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/52 , B01L3/527 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/274 , G01N21/6428 , G01N21/6452 , G01N35/00069 , G01N2035/00158
Abstract: Disclosed is a microassay testing system, including a microfluidic cartridge and a compact microprocessor-controlled instrument for fluorometric assays in liquid samples, the cartridge having integrated process controls and positive and negative assay controls. The instrument has a scanning detector head incorporating multiple optical channels. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a process control. Integrated positive and negative assay controls provide enhanced assay validation capabilities and facilitate analysis of test results. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.
Abstract translation: 公开了一种微量测定系统，包括微流控筒和用于液体样品中荧光测定的紧凑型微处理器控制仪器，该滤芯具有集成的过程控制和阳性和阴性测定对照。 该仪器具有并入多个光通道的扫描检测器头。 在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与过程控制相关联的第二荧光团。 积分的阳性和阴性测定对照提供增强的测定验证功能，并便于分析测试结果。 应用包括基于靶核酸的PCR扩增和荧光测定的分子生物学测定。
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公开(公告)号：WO2017143120A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018268
申请日：2017-02-17
Applicant: MICRONICS, INC.
Inventor： KOLB, Andrew , BRAGD, Matthew, Scott , BATTRELL, C., Frederick
CPC classification number: B01F13/0059 , B01F11/0071
Abstract: A microfluidic mixing device comprising two bellows pumps (105, 115), microfluidic cartridges comprising the same and methods for use of the same are provided. The disclosed device enables efficient mixing of samples at the microfluidic scale. More particularly, the microfluidic mixing device comprises: a first bellows pump (105); a second bellows pump (115); a first microchannel fluidly interconnecting the first bellows pump (105) with a sample inlet and a reagent reservoir, wherein the first microchannel comprises a valve (V10) interposed between the pump and the inlet, and a valve (V1) interposed between the pump and the reservoir; a second microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump (115), wherein the second micro channel comprises a valve (V11) interposed between the first and second pump; a third microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump, wherein the third micro channel comprises a valve (V11) interposed between the first and second pump; a first and second pneumatic member pneumatically connected to the first and second bellows pumps; wherein, the volume of the second bellows pump (115) is greater than the volume of the first bellows pump (105).
Abstract translation: 提供了一种包括两个波纹管泵（105,115）的微流体混合装置，包括其的微流体筒及其使用方法。 所公开的装置能够在微流体规模上有效地混合样品。 更特别地，微流体混合装置包括：第一波纹管泵（105）; 第二波纹管泵（115）; 将所述第一波纹管泵（105）与样品入口和试剂储存器流体互连的第一微通道，其中所述第一微通道包括介于所述泵和所述入口之间的阀（V10）以及介于所述泵和所述入口之间的阀（V1） 水库; 将所述第一波纹管泵（105）与所述第二波纹管泵（115）流体互连的第二微通道，其中所述第二微通道包括插入在所述第一和第二泵之间的阀（V11） 将所述第一波纹管泵（105）与所述第二波纹管泵流体互连的第三微通道，其中所述第三微通道包括插入在所述第一泵和所述第二泵之间的阀（V11） 气动连接到第一和第二波纹管泵的第一和第二气动元件; 其中第二波纹管泵（115）的容积大于第一波纹管泵（105）的容积。
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Patent Agency Ranking
公开(公告)号：WO2016176613A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/030194
申请日：2016-04-29
Applicant: MICRONICS, INC.
Inventor： KOLB, Andrew , LOFQUIST, Alan, K. , BATTRELL, C., Frederick
IPC: A61B5/15
CPC classification number: A61B10/0096 , A61B10/0045 , A61B10/02 , B01L3/50825 , B01L2200/026 , B01L2200/027 , B01L2200/16 , B01L2300/043 , B01L2300/044 , B01L2300/0681 , B01L2400/0683 , G01N1/00
Abstract: A specimen collection and delivery apparatus for collecting clinical specimens and delivery of samples thereof to, e.g., microfluidic testing devices for diagnostic analysis is disclosed. The specimen collection and delivery apparatus includes a closure housing for coupling with a sample tube at one end, an open luer for coupling with a complementary luer on a microfluidic device at the other end, and a filter matrix disposed in the interior. The filter matrix is air permeable and liquid impermeable at atmospheric pressure and prevents sample from flowing through the open luer end when coupled to a sample tube containing a specimen. Under vacuum, the liquid sample fraction of the specimen can be drawn through the filter matrix and into the microfluidic testing device through the luer connection for diagnostic analysis.
Abstract translation: 公开了用于收集临床标本并将其样品递送到例如用于诊断分析的微流体测试装置的样本收集和递送装置。 样品收集和输送装置包括用于在一端与样品管连接的封闭壳体，用于与在另一端的微流体装置上的互补鲁棒耦合的开口鲁尔以及设置在内部的过滤器矩阵。 过滤器基体在大气压力下是透气的和液体不可渗透的，并且当与包含样品的样品管相耦合时，防止样品流过开口鲁尔端。 在真空下，样品的液体样品分数可以通过过滤器基质并通过鲁尔连接进入微流体测试装置进行诊断分析。
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公开(公告)号：EP3416738A1
公开(公告)日：2018-12-26
申请号：EP17708105.6
申请日：2017-02-17
Applicant: Micronics, Inc.
Inventor： KOLB, Andrew , BRAGD, Matthew, Scott , BATTRELL, C., Frederick
Abstract: A microfluidic mixing device comprising two bellows pumps (105, 115), microfluidic cartridges comprising the same and methods for use of the same are provided. The disclosed device enables efficient mixing of samples at the microfluidic scale. More particularly, the microfluidic mixing device comprises: a first bellows pump (105); a second bellows pump (115); a first microchannel fluidly interconnecting the first bellows pump (105) with a sample inlet and a reagent reservoir, wherein the first microchannel comprises a valve (V10) interposed between the pump and the inlet, and a valve (V1) interposed between the pump and the reservoir; a second microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump (115), wherein the second micro channel comprises a valve (V11) interposed between the first and second pump; a third microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump, wherein the third micro channel comprises a valve (V11) interposed between the first and second pump; a first and second pneumatic member pneumatically connected to the first and second bellows pumps; wherein, the volume of the second bellows pump (115) is greater than the volume of the first bellows pump (105).
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6.发明公开MICROFLUIDIC CARTRIDGES AND APPARATUS WITH INTEGRATED ASSAY CONTROLS FOR ANALYSIS OF NUCLEIC ACIDS 审中-公开微流体卡盒及其装置综合测试控件核酸分析
公开(公告)号：EP3154693A1
公开(公告)日：2017-04-19
申请号：EP15733572.0
申请日：2015-06-11
Applicant: Micronics, Inc.
Inventor： HOFFMAN, Daniel , BERGDAHL, Asa , COUCH, Megan , RIVERA, Rafael , BRAGD, Matthew Scott , LOFQUIST, Alan, K. , KOLB, Andrew , KAY, Justin, L.
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/52 , B01L3/527 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/274 , G01N21/6428 , G01N21/6452 , G01N35/00069 , G01N2035/00158
Abstract: Disclosed is a microassay testing system, including a microfluidic cartridge and a compact microprocessor-controlled instrument for fluorometric assays in liquid samples, the cartridge having integrated process controls and positive and negative assay controls. The instrument has a scanning detector head incorporating multiple optical channels. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a process control. Integrated positive and negative assay controls provide enhanced assay validation capabilities and facilitate analysis of test results. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.
Abstract translation: 本发明提供一种微化验测试系统，包括微流体盒和用于液体样品中的荧光分析的紧凑微处理器控制的仪器，盒具有集成的过程控制以及阳性和阴性测定对照。 该仪器具有扫描检测器头包含多种光信道。 在一个优选的配置中，该测定是使用双通道光学用于监控与目标分析物和与过程控制相关联的第二荧光团相关联的第一荧光团验证。 集成阳性和阴性测定对照提供增强的实验验证能力和促进测试结果的分析。 应用包括基于对靶核酸和在一般荧光分析PCR扩增的分子生物学测定法。
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公开(公告)号：EP3288459A1
公开(公告)日：2018-03-07
申请号：EP16787253.0
申请日：2016-04-29
Applicant: Micronics, Inc.
Inventor： KOLB, Andrew , LOFQUIST, Alan, K. , BATTRELL, C., Frederick
IPC: A61B5/15
CPC classification number: A61B10/0096 , A61B10/0045 , A61B10/02 , B01L3/50825 , B01L2200/026 , B01L2200/027 , B01L2200/16 , B01L2300/043 , B01L2300/044 , B01L2300/0681 , B01L2400/0683 , G01N1/00
Abstract: A specimen collection and delivery apparatus for collecting clinical specimens and delivery of samples thereof to, e.g., microfluidic testing devices for diagnostic analysis is disclosed. The specimen collection and delivery apparatus includes a closure housing for coupling with a sample tube at one end, an open luer for coupling with a complementary luer on a microfluidic device at the other end, and a filter matrix disposed in the interior. The filter matrix is air permeable and liquid impermeable at atmospheric pressure and prevents sample from flowing through the open luer end when coupled to a sample tube containing a specimen. Under vacuum, the liquid sample fraction of the specimen can be drawn through the filter matrix and into the microfluidic testing device through the luer connection for diagnostic analysis.
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公开(公告)号：EP2935908A1
公开(公告)日：2015-10-28
申请号：EP13865265.6
申请日：2013-12-20
Applicant: Micronics, Inc.
Inventor： KOLB, Andrew , SPRAGUE, Isaac , KAY, Justin, L. , BRAGD, Matthew, Scott , STONE, Martha
IPC: F15C3/04
CPC classification number: B01L3/50273 , B01L3/502707 , B01L3/502738 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B29C43/021 , B29C65/16 , B29K2101/00 , B29L2009/00 , B29L2031/7496 , B81B2201/052 , B81C1/00119 , F04B43/043 , F16K99/0015 , F16K99/0059 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , Y10T156/1026
Abstract: Fluidic cartridges, and manufacture thereof, having a plurality of circuit element subtypes containing pneumatically operated diaphragm members, where the diaphragm materials are selected for yield point, chemical resistance, breathability and other properties individually according to the fluidic element subtype are provided. A process of in-situ edge-bonded decoupage for forming diaphragm members inside a cartridge, and fluidic circuits having diaphragm members as active and passive circuit elements, including pumps, valves, vents, waste receptacles, reagent reservoirs, and cuvettes with optical windows, where the material composition of each individual diaphragm member may be selected from an assortment of materials during manufacture are also provided.
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