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公开(公告)号：US20240358652A1
公开(公告)日：2024-10-31
申请号：US18291808
申请日：2022-08-17
Applicant: Monash University
Inventor： Hareth Basim Ali AL-WASSITI , Colin William POUTON , Kha Tu Joan HO
IPC: A61K9/51 , A61K31/713 , A61K39/00 , A61K48/00 , A61P37/08
CPC classification number: A61K9/5146 , A61K9/5123 , A61K31/713 , A61K39/0005 , A61K48/0041 , A61P37/08 , A61K2039/53 , A61K2039/55555 , A61K2039/572
Abstract: The present invention is directed to lipid nanoparticles, formulations containing lipid nanoparticles and methods of treating diseases or conditions with said lipid nanoparticles and formulations thereof. A lipid nanoparticle comprising (a) an active agent; (b) a cationic and/or ionisable lipid comprising from about 40 mol % to about 60 mol % of the total lipid present in the nanoparticle; (c) a phospholipid comprising from about 5 mol % to about 20 mol % of the total lipid present in the nanoparticle; (d) a structural lipid comprising from about 30 mol % to about 50 mol % of the total lipid present in the nanoparticle; (e) a PEGylated lipid comprising from about 0.05 mol % to less than 0.5 mol % of the total lipid present in the nanoparticle.
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公开(公告)号：US20250099572A1
公开(公告)日：2025-03-27
申请号：US18291812
申请日：2022-08-17
Applicant: Monash University
IPC: A61K39/215 , A61K39/00 , A61P37/04 , C07K14/005
Abstract: The invention relates to vaccine compositions for inducing an immune response to a coronavirus in a subject, and uses thereof. In particular, the vaccine comprises of a chimeric or fusion protein comprising a) a N-terminal secretion signal peptide; b) an amino acid sequence of the receptor binding domain (RBD) of a spike protein of a coronavirus; and c) a C-terminal domain comprising a transmembrane region and a cytoplasmic region. In a preferred embodiment, the signal peptide, RBD, transmembrane region, and cytoplasmic region are derived from SARS-CoV-2, and that the vaccine composition is formulated as a lipid nanoparticle (LNP).
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