公开(公告)号：US20240358652A1

公开(公告)日：2024-10-31

申请号：US18291808

申请日：2022-08-17

Applicant: Monash University

Inventor： Hareth Basim Ali AL-WASSITI ,  Colin William POUTON ,  Kha Tu Joan HO

IPC: A61K9/51 ,  A61K31/713 ,  A61K39/00 ,  A61K48/00 ,  A61P37/08

CPC classification number: A61K9/5146 ,  A61K9/5123 ,  A61K31/713 ,  A61K39/0005 ,  A61K48/0041 ,  A61P37/08 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/572

Abstract: The present invention is directed to lipid nanoparticles, formulations containing lipid nanoparticles and methods of treating diseases or conditions with said lipid nanoparticles and formulations thereof. A lipid nanoparticle comprising (a) an active agent; (b) a cationic and/or ionisable lipid comprising from about 40 mol % to about 60 mol % of the total lipid present in the nanoparticle; (c) a phospholipid comprising from about 5 mol % to about 20 mol % of the total lipid present in the nanoparticle; (d) a structural lipid comprising from about 30 mol % to about 50 mol % of the total lipid present in the nanoparticle; (e) a PEGylated lipid comprising from about 0.05 mol % to less than 0.5 mol % of the total lipid present in the nanoparticle.

公开(公告)号：US20200246487A1

公开(公告)日：2020-08-06

申请号：US16622136

申请日：2018-06-08

Applicant: MONASH UNIVERSITY

Inventor： Colin William POUTON ,  Kha Tu Joan HO ,  Paul James WHITE ,  Catherine Thoa BUI ,  Nabila AKHTAR ,  Hareth Ali AL-WASSITI

IPC: A61K48/00 ,  A61K9/14 ,  C12N15/88 ,  A61K9/00

Abstract: Non-viral nucleic acid delivery agents and methods for the delivery or transfer of nucleic acid molecules to target cells are disclosed. The agents comprise a complex of a nucleic acid cargo for delivery, one or more lipopeptide compound, and one or more polymeric charge-neutralising agent, and the complex is in the form of a particle with substantially neutral or negative surface charge. The agents and methods may be useful in a variety of applications such as therapies (including gene therapies and nucleic acid vaccinations) for diseases and medical disorders.

公开(公告)号：US20250099572A1

公开(公告)日：2025-03-27

申请号：US18291812

申请日：2022-08-17

Applicant: Monash University

Inventor： Hareth Basim Ali AL-WASSITI ,  Colin William POUTON ,  Stewart Alastair FABB

IPC: A61K39/215 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005

Abstract: The invention relates to vaccine compositions for inducing an immune response to a coronavirus in a subject, and uses thereof. In particular, the vaccine comprises of a chimeric or fusion protein comprising a) a N-terminal secretion signal peptide; b) an amino acid sequence of the receptor binding domain (RBD) of a spike protein of a coronavirus; and c) a C-terminal domain comprising a transmembrane region and a cytoplasmic region. In a preferred embodiment, the signal peptide, RBD, transmembrane region, and cytoplasmic region are derived from SARS-CoV-2, and that the vaccine composition is formulated as a lipid nanoparticle (LNP).