公开(公告)号：MY190022A

公开(公告)日：2022-03-22

申请号：MYPI2018702461

申请日：2018-07-16

Applicant: NANOMALAYSIA BERHAD ,  IBM

Inventor： MOHD ZULKEFELI BIN MAT JUSOH ,  ALSHAKIM NELSON ,  VICTORIA A PIUNOVA ,  JOSEPH SLY

IPC: C08F212/08 ,  A61K9/00 ,  A61K9/107 ,  A61K9/20 ,  A61K47/32 ,  A61K47/34 ,  A61K47/42 ,  C08F212/36 ,  C08F295/00 ,  C08F297/02

Abstract: CO-DELIVERY OF CHOLESTEROL LOWERING DRUGS AND NUTRACEUTICALS Star polymer occlusion complexes were prepared comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent amphiphilic polymer arms, ii) a nutraceutical (such as coenzyme Q10), and iii) a cholesterol-lowering drug (such as simvastatin). An initial occlusion complex formed with the nutraceutical and the star polymer exhibited improved binding properties for the cholesterol-lowering drug, resulting in improved loading efficiencies for the cholesterol-lowering drug. The star polymer occlusion complexes have utility in the medical treatment of high blood cholesterol.

公开(公告)号：GB2543454A

公开(公告)日：2017-04-19

申请号：GB201701201

申请日：2015-07-13

Applicant: IBM

Inventor： YOUNG-HYE NA ,  VICTOR LEE ,  GERAUD JEAN-MICHEL DUBOIS ,  ROBERT DENNIS MILLER ,  JOSEPH SLY

IPC: B01D69/12 ,  B01D67/00 ,  B01D69/02 ,  B01D71/80 ,  B32B27/00

Abstract: A thin film composite membrane (TFC) includes an active layer (26) on a support (24). The active layer (26) includes at least 8 barrier layers (28) of star-polymers each having at least three linear polymers attached at a central core. Each of the barrier layers (28) has a thickness between 5 and 50 nm, and the barrier layers (28) have alternating charge.

公开(公告)号：GB2543454B

公开(公告)日：2017-10-11

申请号：GB201701201

申请日：2015-07-13

Applicant: IBM

Inventor： YOUNG-HYE NA ,  VICTOR LEE ,  GERAUD JEAN-MICHEL DUBOIS ,  ROBERT DENNIS MILLER ,  JOSEPH SLY

IPC: B01D69/12 ,  B01D67/00 ,  B01D69/02 ,  B01D71/80 ,  B32B27/00

Abstract: A thin film composite membrane (TFC) includes an active layer on a support. The active layer includes at least 8 barrier layers of star-polymers each having at least three linear polymers attached at a central core. Each of the barrier layers has a thickness between 5 and 50 nm, and the barrier layers have alternating charge.