公开(公告)号：GB2141544B

公开(公告)日：1986-10-15

申请号：GB8413167

申请日：1984-05-23

Applicant: NAT RES DEV

Inventor： LOWE CHRISTOPHER ROBIN ,  EARLEY FERGUS GERARD PAUL

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61K39/385 ,  C12Q1/00 ,  G01N27/30 ,  G01N27/327 ,  G01N27/414 ,  G01N33/543 ,  G01N33/544 ,  G01N33/50 ,  H01L21/00

Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.

公开(公告)号：DK256784A

公开(公告)日：1984-11-26

申请号：DK256784

申请日：1984-05-24

Applicant: NAT RES DEV

Inventor： LOWE CHRISTOPHER ROBIN ,  EARLEY FERGUS GERARD PAUL

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61K39/385 ,  C12Q1/00 ,  G01N27/30 ,  G01N27/327 ,  G01N27/414 ,  G01N33/543 ,  G01N33/544 ,  G01N

Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.

公开(公告)号：GB2141544A

公开(公告)日：1984-12-19

申请号：GB8413167

申请日：1984-05-23

Applicant: NAT RES DEV

Inventor： LOWE CHRISTOPHER ROBIN ,  EARLEY FERGUS GERARD PAUL

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61K39/385 ,  C12Q1/00 ,  G01N27/30 ,  G01N27/327 ,  G01N27/414 ,  G01N33/543 ,  G01N33/544 ,  G01N33/50 ,  H01L21/00

Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.

公开(公告)号：DK256784D0

公开(公告)日：1984-05-24

申请号：DK256784

申请日：1984-05-24

Applicant: NAT RES DEV

Inventor： LOWE CHRISTOPHER ROBIN ,  EARLEY FERGUS GERARD PAUL

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61K39/385 ,  C12Q1/00 ,  G01N27/30 ,  G01N27/327 ,  G01N27/414 ,  G01N33/543 ,  G01N33/544 ,  G01N27

Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.

公开(公告)号：DE3468146D1

公开(公告)日：1988-01-28

申请号：DE3468146

申请日：1984-05-23

Applicant: NAT RES DEV

Inventor： LOWE CHRISTOPHER ROBIN ,  EARLEY FERGUS GERARD PAUL

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61K39/385 ,  C12Q1/00 ,  G01N27/30 ,  G01N27/327 ,  G01N27/414 ,  G01N33/543 ,  G01N33/544 ,  G01N33/551 ,  G01N33/552

Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.