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公开(公告)号：WO9013634A3
公开(公告)日：1991-05-16
申请号：PCT/GB9000727
申请日：1990-05-11
Applicant: NAT RES DEV
IPC: C12N1/20 , C12M1/40 , C12N9/04 , C12N9/18 , C12P17/18 , C12Q1/00 , C12Q1/32 , C12Q1/44 , C12R1/01 , C12R1/40 , G01N27/327 , G01N27/416
Abstract: Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidises morphine to morphinone, with the aid of a cofactor. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.
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公开(公告)号：GB2231332B
公开(公告)日：1993-04-21
申请号：GB9010561
申请日：1990-05-11
Applicant: NAT RES DEV , BRITISH TECH GROUP
IPC: C12N1/20 , C12M1/40 , C12N9/04 , C12N9/18 , C12P17/18 , C12Q1/00 , C12Q1/32 , C12Q1/44 , C12R1/01 , C12R1/40 , G01N27/327 , G01N27/416
Abstract: Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidizes morphine to morphinone, with the aid of a cofactor. More particularly, the invention pertains to a process for preparing a 6-ketone from morphine or a methyl or ethyl derivative thereof. The process comprises oxidizing morphine or an ether derivative in the presence of a morphine dehydrogenase and the cofactor NADP+. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.
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公开(公告)号：HUT59959A
公开(公告)日：1992-07-28
申请号：HU440890
申请日：1990-05-11
Applicant: NAT RES DEV
IPC: C12N1/20 , C12M1/40 , C12N9/04 , C12N9/18 , C12P17/18 , C12Q1/00 , C12Q1/32 , C12Q1/44 , C12R1/01 , C12R1/40 , G01N27/327 , G01N27/416
Abstract: Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidizes morphine to morphinone, with the aid of a cofactor. More particularly, the invention pertains to a process for preparing a 6-ketone from morphine or a methyl or ethyl derivative thereof. The process comprises oxidizing morphine or an ether derivative in the presence of a morphine dehydrogenase and the cofactor NADP+. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.
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公开(公告)号：DE3468146D1
公开(公告)日：1988-01-28
申请号：DE3468146
申请日：1984-05-23
Applicant: NAT RES DEV
Inventor： LOWE CHRISTOPHER ROBIN , EARLEY FERGUS GERARD PAUL
IPC: A61B5/145 , A61B5/1455 , A61B5/15 , A61K39/385 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/414 , G01N33/543 , G01N33/544 , G01N33/551 , G01N33/552
Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.
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Patent Agency Ranking
公开(公告)号：HU904408D0
公开(公告)日：1992-01-28
申请号：HU440890
申请日：1990-05-11
Applicant: NAT RES DEV
IPC: C12N1/20 , C12M1/40 , C12N9/04 , C12N9/18 , C12P17/18 , C12Q1/00 , C12Q1/32 , C12Q1/44 , C12R1/01 , C12R1/40 , G01N27/327 , G01N27/416
Abstract: Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidizes morphine to morphinone, with the aid of a cofactor. More particularly, the invention pertains to a process for preparing a 6-ketone from morphine or a methyl or ethyl derivative thereof. The process comprises oxidizing morphine or an ether derivative in the presence of a morphine dehydrogenase and the cofactor NADP+. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.
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公开(公告)号：CA2055442A1
公开(公告)日：1990-11-13
申请号：CA2055442
申请日：1990-05-11
Applicant: NAT RES DEV
IPC: C12N1/20 , C12M1/40 , C12N9/04 , C12N9/18 , C12P17/18 , C12Q1/00 , C12Q1/32 , C12Q1/44 , C12R1/01 , C12R1/40 , G01N27/327 , G01N27/416 , C12N9/02
Abstract: Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidizes morphine to morphinone, with the aid of a cofactor. More particularly, the invention pertains to a process for preparing a 6-ketone from morphine or a methyl or ethyl derivative thereof. The process comprises oxidizing morphine or an ether derivative in the presence of a morphine dehydrogenase and the cofactor NADP+. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.
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公开(公告)号：GB2141544B
公开(公告)日：1986-10-15
申请号：GB8413167
申请日：1984-05-23
Applicant: NAT RES DEV
Inventor： LOWE CHRISTOPHER ROBIN , EARLEY FERGUS GERARD PAUL
IPC: A61B5/145 , A61B5/1455 , A61B5/15 , A61K39/385 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/414 , G01N33/543 , G01N33/544 , G01N33/50 , H01L21/00
Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.
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公开(公告)号：DK256784A
公开(公告)日：1984-11-26
申请号：DK256784
申请日：1984-05-24
Applicant: NAT RES DEV
Inventor： LOWE CHRISTOPHER ROBIN , EARLEY FERGUS GERARD PAUL
IPC: A61B5/145 , A61B5/1455 , A61B5/15 , A61K39/385 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/414 , G01N33/543 , G01N33/544 , G01N
Abstract: The invention relates to a device useful in diagnostics in which a biochemical species is attached to the surface of a sensor, especially to the gate of a field effect transistor. In such a "BIOCHEMFET" it has been a problem to attach two or more biochemical species to the surface of the sensor, especially to the gates of a multi-gated FET. It has now been found possible to bond a group having a photoactivatable function covalently to the sensor surface, photo-expose the resultant modified surface selectively, e.g. through a mask, and bond the biochemical species, e.g. a hapten, antigen, antibody, lectin or enzyme, to the photoactivated function. In this way the biochemical species becomes attached in selected areas only. In view of the success of this technique realised under conditions of miniaturisation, the invention makes possible a "printed circuits for proteins". … The invention includes the device, process of manufacture thereo, use for diagnostic purposes and a diagnostic kit of the device and a partner capable of binding to the biochemical species.
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公开(公告)号：GB2231332A
公开(公告)日：1990-11-14
申请号：GB9010561
申请日：1990-05-11
Applicant: NAT RES DEV
IPC: C12N1/20 , C12M1/40 , C12N9/04 , C12N9/18 , C12P17/18 , C12Q1/00 , C12Q1/32 , C12Q1/44 , C12R1/01 , C12R1/40 , G01N27/327 , G01N27/416
Abstract: Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidises morphine to morphinone, with the aid of a cofactor. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.
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