公开(公告)号：JP2004251900A

公开(公告)日：2004-09-09

申请号：JP2004023637

申请日：2004-01-30

Applicant: Nec Corp ,  Tanita Corp ,  日本電気株式会社 ,  株式会社タニタ

Inventor： SAITO SOICHI ,  ITO SHIGEFUMI

IPC: G01N27/416 ,  C12M1/40 ,  G01N27/327

Abstract: PROBLEM TO BE SOLVED: To provide a means for stabilizing sensor sensitivity characteristic, in a measurement using a chemical sensor, by rapidly solving the instability of the sensor sensitivity characteristic which is found early when starting the use of the chemical sensor by dipping the dry chemical sensor in a buffer solution as a storage solution and applying a measuring potential between a working electrode and a reference electrode. SOLUTION: When the use of the chemical is started, the dry chemical sensor is dipped in the buffer solution as the storage solution, and a two-stage initial processing operation is then performed, whereby the sensor sensitivity characteristic can be stabilized. The two-stage initial processing operation comprises applying a first initial processing potential having the same direction as the measurement potential and showing an absolute value larger than the measurement potential between the working electrode and the reference electrode for a first initial processing time followed by changing to a second initial processing potential equal to the measurement potential, and applying the second initial processing potential for a second initial processing time. COPYRIGHT: (C)2004,JPO&NCIPI

公开(公告)号：JP2004125811A

公开(公告)日：2004-04-22

申请号：JP2004011551

申请日：2004-01-20

Applicant: Nec Corp ,  日本電気株式会社

Inventor： ITO SHIGEFUMI ,  OHASHI AKIKIMI

IPC: G01N33/493 ,  G01N27/26 ,  G01N27/327

Abstract: PROBLEM TO BE SOLVED: To provide a test instrument for use with a method of providing business for providing at-home health management services, whereby it is possible to manage the health of a number of people at home in an integrated manner without getting them into trouble. SOLUTION: The urine test instrument comprises a urine collector 102 for collecting urine in a toilet; a biosensor 103 replaceably mounted within the urine collector 102 and producing an electric signal upon sensing a predetermined chemical component contained in urine; a support part 104 adapted to automatically or manually move the urine collector 102 from its storage position to a predetermined service position and vice versa while supporting the urine collector 102 and supporting a transmission path of the electric signal; and a signal processing part 105 which processes the electric signal input from the biosensor through the transmission path. COPYRIGHT: (C)2004,JPO

Abstract translation: 要解决的问题：提供一种用于提供家庭健康管理服务的业务的方法的测试仪器，从而可以以综合的方式管理一些家庭中的人的健康，而没有 让他们陷入困境 解决方案：尿液检测仪器包括用于在厕所中收集尿液的尿液收集器102; 可替代地安装在集尿器102内的生物传感器103，并且在感测到尿中包含的预定化学成分时产生电信号; 支撑部分104适于自动或手动地将尿液收集器102从其存储位置移动到预定的使用位置，反之亦然，同时支持尿液收集器102并支持电信号的传输路径; 以及信号处理部分105，其通过传输路径处理从生物传感器输入的电信号。 版权所有（C）2004，JPO

公开(公告)号：JPH02168153A

公开(公告)日：1990-06-28

申请号：JP32521688

申请日：1988-12-22

Applicant: NEC CORP

Inventor： KAWANA YOSHIE ,  ITO SHIGEFUMI ,  MIYAMOTO SHIGEYUKI

IPC: G01N27/327

Abstract: PURPOSE:To form an immobilized enzyme film with uniform thickness by developing a wafer and a solution of protein while cooling the both to equal to or lower than 15 deg.C when said wafer onto which said solution of protein is developed is rotated to form a thin film. CONSTITUTION:A photoresist solution is developed on a substrate 4 of sapphire having an ion sensor 5 of semiconductor field effect type thereon, and the substrate 4 is rotated at 3,000rpm for 30 seconds. Then, the substrate is pre-baked, exposed and developed with the use of a photomask, so that a part of a photoresist film 6 where an immobilized enzyme film 7 is to be formed is removed. Thereafter, 0.6ml PIPES buffer solution containing, e.g., 60mg/ml glucose oxidase, 15% bovine serum albumin and 1% glutaraldehyde is developed on the wafer. At this time, the buffer solution is 0 deg.C and the wafer is 4 deg.C. The wafer is immediately rotated at 2,000rpm for 30 seconds so that the solution is applied all over the surface of the wafer. After the enzyme film is completely crosslinked through one-hour reaction at 20 deg.C, the wafer is soaked in acetone, whereby the film 6 and the film 7 applied on the film 6 are removed. Thus, the film 7 having uniform thickness can be formed.

公开(公告)号：JP2002318855A

公开(公告)日：2002-10-31

申请号：JP2001103321

申请日：2001-04-02

Applicant: NEC CORP

Inventor： ITO SHIGEFUMI ,  OHASHI AKIKIMI

IPC: A61B5/00 ,  A61B5/20 ,  G01N27/327 ,  G01N33/493 ,  G06Q50/00 ,  G06Q50/10 ,  G06Q50/22 ,  G06F17/60

Abstract: PROBLEM TO BE SOLVED: To provide a home health management service business capable of intensively conducting the health management of many persons at home without putting the person at home to trouble. SOLUTION: A service recipient device 2 for automatically generating electrical measurement data by measuring glucose contained in urine excreted from a human body at home in time series is distributed to a registered person at home. The measurement data for every person at home is collected to a health management center 1 from the person at home through the Internet 3. Service necessary for maintaining a health of the person at home is provided by managing a health condition of the person at home with time on the basis of health management basic data and the collected measurement data.

公开(公告)号：JPH0471547A

公开(公告)日：1992-03-06

申请号：JP18058690

申请日：1990-07-10

Applicant: NEC CORP

Inventor： ITO SHIGEFUMI

IPC: G01N33/483 ,  A61B5/00 ,  A61B5/15 ,  A61B10/00 ,  A61B10/02 ,  G01N33/487

Abstract: PURPOSE:To measure the electrical conductivity of an exudate, calculate the concentration rate, correct the organism-related material concentration, and obtain the correct concentration change by installing a pair of electrical conductivity measuring electrodes on a exudate flow path from the opening section of a cell to a decompression suction port. CONSTITUTION:A self-adhesive tape 2 portion provided on the cell 1 of a suction exudate collecting device is closely stuck to a skin 3, and a skin portion is sucked by a suction pump from a decompression suction port 4 via a spacer 5 provided on an opening section 7. The collected suction exudate 6 is exuded and brought into contact with electrodes 9 immediately before a liquid feed pipe 8. The electrical conductivity is measured, the measured value is monitored, the level of concentration can be measured. The electrodes 9 are installed into a double-circular shape, and the electrical conductivity of the exuded liquid can be measured in real-time. The electrodes 9 are made of platinum, gold, or carbon, and a platinum black electrode has good stability in particular.

公开(公告)号：JPH1026601A

公开(公告)日：1998-01-27

申请号：JP18028696

申请日：1996-07-10

Applicant: NEC CORP

Inventor： MATSUMOTO TATSU ,  FURUSAWA MASAKO ,  ITO SHIGEFUMI ,  NAKAMOTO SHINYA

IPC: G01N27/327 ,  C12Q1/00

Abstract: PROBLEM TO BE SOLVED: To avoid the deterioration or measuring accuracy by the interference material in a sample to be measured by forming a hydrogen peroxide electrode on an insulating substrate, and forming a specified sample film thereon. SOLUTION: For example, on a hydrogen peroxide electrode 2 formed on an insulating substrate 1, a γ-amino-propyl tri-ethoxy-silane film 3, an acetyl cellulose film 4, a perfluorocarbon sulfonic acid resin film 5 and an organic polymer film 6, to which the enzyme having a catalyst function 13 fixed, are sequentially formed in this structure. The γ-amino-propyl tri-ethoxy-silane film 3 and the acetyl cellulose film 4, which is the cellulose derivative, have the limiting permeability, which excludes the molecules having the large molecular weight by the minute layer having infinitesimal holes. The perfluorocarbon sulfonic acid resin film 5, which is the ion-exchange resin having perfluorocarbon as the skelton, has the limiting permeability, which excludes charged molecules and atoms. Therefore, the effect of the limiting permeability for high- concentration interference material is improved.

公开(公告)号：JPH07209242A

公开(公告)日：1995-08-11

申请号：JP22902892

申请日：1992-08-28

Applicant: NEC CORP

Inventor： ITO SHIGEFUMI

IPC: G01N27/414 ,  A61B5/00 ,  C12Q1/00 ,  G01N27/327 ,  G11C13/02 ,  H01L21/8247 ,  H01L27/10 ,  H01L27/115 ,  H01L29/78

Abstract: PURPOSE:To provide a biosensor equipped with a memory for storing measurement data in which a user is not required to carry out the calibrating operation. CONSTITUTION:The biosensor is a potentiometric glucose sensor comprising two ion-sensitive HET transistors and a pseudo reference electrode, wherein a glucose oxidase fixing film 2 is formed on the gate of an ENFET 1 while an albumin fixing film 5 is formed on the gate of an REFET 4 and a pseudo reference electrode 3 is deposited with gold. A memory 6 is provided on the same substrate in order to store the data of manufacture, lot number, effective shelf life, characteristic, and the management data of the sensor. Furthermore, the data of measurement, continuous operating time, and measurement can be stored, as required, and the sensor itself serves as a recording medium.

公开(公告)号：JP2004038990A

公开(公告)日：2004-02-05

申请号：JP2003285177

申请日：2003-08-01

Applicant: Nec Corp ,  日本電気株式会社

Inventor： ITO SHIGEFUMI ,  OHASHI AKIKIMI

IPC: E03D9/00 ,  A61B5/00 ,  G06Q50/22 ,  G06F17/60

Abstract: PROBLEM TO BE SOLVED: To provide a health management service provision business which can centrally manage health care for a large number of people who stay at home while saving the people staying at home time and trouble. SOLUTION: A service beneficiary device 2 which automatically generates electric measurement data by measuring sugar in urine evacuated from a human body with time at home is distributed to registered people who stays at home. The measurement data for each person staying at home is collected at a health care center 1 through the Internet 3. Health conditions of the people staying at home are managed with time based on health care basic data and the collected measurement data, and necessary service to maintain health of the people staying at home is provided. COPYRIGHT: (C)2004,JPO

公开(公告)号：JPH10221221A

公开(公告)日：1998-08-21

申请号：JP2161097

申请日：1997-02-04

Applicant: NEC CORP

Inventor： MATSUMOTO TATSU ,  ITO SHIGEFUMI

IPC: G01N33/48 ,  A61B5/00 ,  A61B5/15 ,  A61B10/02 ,  B81B1/00 ,  G01N1/02 ,  G01N1/10 ,  A61B5/14

Abstract: PROBLEM TO BE SOLVED: To reduce the manufacturing cost, simply collect a slight quantity of a body fluid, and increase utilization efficiency by collecting a liquid on the epithelium of an organism into a liquid guide path via a capillary phenomenon. SOLUTION: When the opening end face of an opening section 3 forming a contact face with a skin is pressed to the face of the skin 5 holding a liquid 4 to be collected, the face of the skin 5 is swollen into the opening section 3, the liquid 4 on the face of the skin 5 is brought into contact with only an end face opened at the inlet of a liquid guide path 2, and it is spontaneously collected into the liquid guide path 2 via a capillary phenomenon. The constituting elements of this device are extremely simplified, the manufacturing cost is easily reduced, and it can be properly utilized as an expendable type. The liquid 4 can be collected by a simple action that the device is merely pressed to the skin face 5, and it is excellent in operability. The liquid 4 on the skin 5 is kept in contact with only the opening face of the inlet of the liquid guide path 2, and a slight quantity of the liquid 4 can be collected without loss.

公开(公告)号：JPH05123326A

公开(公告)日：1993-05-21

申请号：JP31971491

申请日：1991-11-08

Applicant: NEC CORP

Inventor： ITO SHIGEFUMI

IPC: A61B10/02 ,  A61B5/15 ,  A61B10/00

Abstract: PURPOSE:To provide a removing equipment and removing method of cutaneous horny layer for effectively, inexpensively and easily removing a cutaneous horny layer. CONSTITUTION:A layered self-adhesive tape 1 is provided on the seat surface of an equipment body 3 having a handle 2. Although a cutaneous horny layer is removed by repeating the contact of the layered self-adhesive tape 1 with a skin surface, the adhesive force is lowered when horny cells are adhesively bonded to the whole surface of the self-adhesive tape part. Therefore, the adhesive force is recovered by peeling the self-adhesive tape one layer by one layer. The self-adhesive tape can easily be peeled by holding a lug 4 by hand. Further, a heating device is provided in the equipment body, and the self-adhesive tape 1 is heated to a proper temperature to reduce the pain of a subject.