公开(公告)号：WO2022261029A2

公开(公告)日：2022-12-15

申请号：PCT/US2022/032402

申请日：2022-06-06

Applicant: NEUBASE THERAPEUTICS, INC.

Inventor： STEPHAN, Dietrich A. ,  BATWAL, Ramesh U. ,  BADEAU, Barry ,  MANN, William R. ,  KILGORE, Austin ,  STOLTZFUS, Dani

IPC: C07C229/08 ,  A61P25/14 ,  C07K14/00 ,  C07C201/00 ,  C07K5/00

Abstract: The present disclosure relates to compounds useful for the detection or modulation of target nucleic acids containing trinucleotide repeats. The present disclosure further relates to methods for treatment of trinucleotide repeat disorders such as polyglutamine diseases, which can include administration of oligonucleotide analogues that can bind pathogenic nucleotide repeats in DNA or RNA.

公开(公告)号：WO2022261030A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/032403

申请日：2022-06-06

Applicant: NEUBASE THERAPEUTICS, INC.

Inventor： STEPHAN, Dietrich A. ,  BATWAL, Ramesh U. ,  BADEAU, Barry ,  KILGORE, Austin ,  STOLTZFUS, Dani

IPC: C07C229/10 ,  A61K38/16 ,  A61K47/42 ,  C07C215/08 ,  C07C225/06 ,  C07C227/18 ,  C07C229/08

Abstract: The present disclosure relates to compounds and methods of modulating target nucleic acids that contain single nucleotide polymorphisms such as KRAS codon 12 mutations. Compounds disclosed herein can preferentially bind a sequence of nucleic acids encoding for a mutant Ras protein, thereby selectively modulating expression of the mutant protein.

公开(公告)号：WO2022132194A2

公开(公告)日：2022-06-23

申请号：PCT/US2021/010058

申请日：2021-12-15

Applicant: NEUBASE THERAPEUTICS, INC.

Inventor： STEPHAN, Dietrich, A. ,  MANN, William ,  BATWAL, Ramesh ,  DI CARO, Valentina ,  BADEAU, Barry ,  KILGORE, Austin ,  DOWDY, Steven ,  STOLTZFUS, Dani

IPC: C07C229/08 ,  C07C229/12 ,  C07C227/14 ,  C07C225/06 ,  C07C229/26 ,  C07K19/00

Abstract: The present disclosure relates to compounds useful for the detection or modulation of target nucleic acids, including DNA and RNA. The present disclosure further relates to methods for treatment of trinucleotide repeat disorders, which can include administration of oligonucleotid analogues that can bind pathogenic nucleotide repeats in DNA or RNA.

公开(公告)号：EP4263491A2

公开(公告)日：2023-10-25

申请号：EP21907331.9

申请日：2021-12-15

Applicant: NeuBase Therapeutics, Inc.

Inventor： STEPHAN, Dietrich, A. ,  BATWAL, Ramesh ,  BADEAU, Barry ,  KILGORE, Austin ,  STOLTZFUS, Dani

IPC: C07C229/08 ,  C07C229/12 ,  C07C227/14 ,  C07C225/06 ,  C07C229/26