公开(公告)号：US20220169630A1

公开(公告)日：2022-06-02

申请号：US17546284

申请日：2021-12-09

Applicant: NOVARTIS AG

Inventor： Peng FU ,  Yu GAI ,  Feng GAO ,  Weiyong KONG ,  Yadong LU ,  Zhongcheng MIN ,  Shaofeng RONG ,  Chutian SHU ,  Can WANG ,  Ruidong WANG ,  Jibin ZHAO ,  Xianglin ZHAO ,  Yi ZHAO ,  Jianguang ZHOU ,  Benjamin MARTIN

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210269416A1

公开(公告)日：2021-09-02

申请号：US17260393

申请日：2019-07-15

Applicant: NOVARTIS AG

Inventor： Peng FU ,  Yu GAI ,  Feng GAO ,  Weiyong KONG ,  Yadong LU ,  Zhongcheng MIN ,  Shaofeng RONG ,  Chutian SHU ,  Can WANG ,  Ruidong WANG ,  Jibin ZHAO ,  Xianglin ZHAO ,  Yi ZHAO ,  Jianguang ZHOU ,  Benjamin MARTIN

IPC: C07D401/06 ,  C07D211/74 ,  C07D209/04

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1/-/-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230348420A1

公开(公告)日：2023-11-02

申请号：US18002291

申请日：2021-06-24

Applicant: Novartis AG

Inventor： Nicolas AMIOT ,  Darija DEDIC ,  Peng FU ,  Fabrice GALLOU ,  Xingxian GU ,  Cornelius HARLACHER ,  Siqian LIU ,  Shuping YAO ,  Jiong YE ,  Jianguang ZHOU

IPC: C07D401/12 ,  C07D401/14 ,  C07D237/08 ,  C07D231/14

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D237/08 ,  C07D231/14

Abstract: The invention relates to a novel process, novel process step(s) and novel intermediate(s) useful for the preparation of 1,4-disubstituted pyridazine compounds, such as 5-(1H-Pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol.