公开(公告)号：US20230203032A1

公开(公告)日：2023-06-29

申请号：US18057505

申请日：2022-11-21

Applicant: Novartis AG

Inventor： Atwood Kim CHEUNG ,  Donglei LIU ,  Stefan PEUKERT ,  Heng GE ,  Yu GAI ,  Xingjuan CHANG

IPC: C07D471/04 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K45/06

Abstract: The invention relates to a compound of formula (I):




or a pharmaceutically acceptable salt thereof, wherein A, R1 and R3 are as described herein, as well as compositions and methods of using such compounds.

公开(公告)号：US20220169630A1

公开(公告)日：2022-06-02

申请号：US17546284

申请日：2021-12-09

Applicant: NOVARTIS AG

Inventor： Peng FU ,  Yu GAI ,  Feng GAO ,  Weiyong KONG ,  Yadong LU ,  Zhongcheng MIN ,  Shaofeng RONG ,  Chutian SHU ,  Can WANG ,  Ruidong WANG ,  Jibin ZHAO ,  Xianglin ZHAO ,  Yi ZHAO ,  Jianguang ZHOU ,  Benjamin MARTIN

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210269416A1

公开(公告)日：2021-09-02

申请号：US17260393

申请日：2019-07-15

Applicant: NOVARTIS AG

Inventor： Peng FU ,  Yu GAI ,  Feng GAO ,  Weiyong KONG ,  Yadong LU ,  Zhongcheng MIN ,  Shaofeng RONG ,  Chutian SHU ,  Can WANG ,  Ruidong WANG ,  Jibin ZHAO ,  Xianglin ZHAO ,  Yi ZHAO ,  Jianguang ZHOU ,  Benjamin MARTIN

IPC: C07D401/06 ,  C07D211/74 ,  C07D209/04

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1/-/-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.