公开(公告)号：EP2562536B1

公开(公告)日：2018-08-01

申请号：EP11178294.2

申请日：2011-08-22

Applicant: NXP B.V.

Inventor： Frederix, Filip ,  Jedema, Friso Jacobus ,  Van Steenwinckel, David ,  Suy, Hilco

IPC: G01N27/403 ,  G01N27/414 ,  C12Q1/68 ,  G01N33/543

CPC classification number: G01N33/5438 ,  C12Q1/6825 ,  G01N27/4145

Abstract: Disclosed is a method for providing a functionalized integrated circuit (10) such that a first sensing electrode (16) comprises at its surface a first receptor molecule (30) for selectively binding to a first analyte of interest (40) and a second sensing electrode (16') comprises at its surface a second receptor molecule (30') for selectively binding to a second analyte of interest (40'); exposing said functionalized integrated circuit to a sample potentially comprising at least one of the first analyte and the second analyte of interest, providing a first bead (60) having a first electrical signature attached to a first molecule (30, 40, 45) having a conformation or an affinity for binding to the first sensing electrode that is dependent on the presence of the first analyte in said sample; providing a second bead (60') having a second electrical signature attached to a second molecule (30', 40', 45') having a conformation or an affinity for binding to the second sensing electrode that is dependent on the presence of the second analyte in said sample; and determining the presence of the electrical signature of the first bead and/or the second bead on the first sensing electrode and the second sensing electrode respectively. An IC (10) for implementing this method is also disclosed. The electrical signature could be the size or the material of the bead.

公开(公告)号：EP2840369A1

公开(公告)日：2015-02-25

申请号：EP13180893.3

申请日：2013-08-19

Applicant: NXP B.V.

Inventor： Van Steenwinckel, David ,  Besling, Willem ,  Humbert, Aurelie ,  Le, Kim Phan ,  Soccol, Dimitri ,  Heil, Stephan ,  Donkers, Johannes ,  Attenborough, Karen ,  Daamen, Roel ,  Gravesteijn, Dirk

IPC: G01J5/20 ,  H01L27/146

CPC classification number: H01L27/14649 ,  G01J5/024 ,  G01J5/20

Abstract: Disclosed is an integrated circuit (100) comprising a cavity (52) defined over a substrate (10) and a membrane (42, 50) arranged to be exposed to infrared radiation suspended over said cavity, said membrane comprising a conductive body (42) and an infrared radiation absorbing polymer (50) covering said conductive body such that the conductive body is shielded from said radiation by said polymer, said conductive body being conductively coupled to a pair of electrodes. A body detection system including such an IC and a method of manufacturing such an IC are also disclosed.

Abstract translation: 公开了一种集成电路（100），其包括限定在衬底（10）上的空腔（52）和布置成暴露于悬挂在所述空腔上的红外辐射的膜（42,50），所述膜包括导电体（42） 以及覆盖所述导电体的红外辐射吸收聚合物（50），使得所述导电体被所述聚合物屏蔽所述辐射，所述导电体与一对电极导电耦合。 还公开了一种包括这种IC的身体检测系统及其制造方法。

公开(公告)号：EP2562536A1

公开(公告)日：2013-02-27

申请号：EP11178294.2

申请日：2011-08-22

Applicant: NXP B.V.

Inventor： Frederix, Filip ,  Jedema, Friso Jacobus ,  Van Steenwinckel, David ,  Suy, Hilco

IPC: G01N27/403 ,  G01N27/414 ,  C12Q1/68 ,  G01N33/543

CPC classification number: G01N33/5438 ,  C12Q1/6825 ,  G01N27/4145

Abstract: Disclosed is a method for providing a functionalized integrated circuit (10) such that a first sensing electrode (16) comprises at its surface a first receptor molecule (30) for selectively binding to a first analyte of interest (40) and a second sensing electrode (16') comprises at its surface a second receptor molecule (30') for selectively binding to a second analyte of interest (40'); exposing said functionalized integrated circuit to a sample potentially comprising at least one of the first analyte and the second analyte of interest, providing a first bead (60) having a first electrical signature attached to a first molecule (30, 40, 45) having a conformation or an affinity for binding to the first sensing electrode that is dependent on the presence of the first analyte in said sample; providing a second bead (60') having a second electrical signature attached to a second molecule (30', 40', 45') having a conformation or an affinity for binding to the second sensing electrode that is dependent on the presence of the second analyte in said sample; and determining the presence of the electrical signature of the first bead and/or the second bead on the first sensing electrode and the second sensing electrode respectively. An IC (10) for implementing this method is also disclosed.
The electrical signature could be the size or the material of the bead.

Abstract translation: 公开了一种用于提供功能化集成电路（10）的方法，使得第一感测电极（16）在其表面上包括用于选择性地结合第一感兴趣分析物（40）的第一受体分子（30）和第二感测电极 （16'）在其表面上包含用于选择性结合第二目标分析物（40'）的第二受体分子（30'）; 将所述功能化集成电路暴露于潜在地包含所述第一分析物和所述第二分析物中的至少一个的样品，提供第一珠（60），所述第一珠（60）具有附着到具有第一分子的第一分子（30,40,45） 构象或对依赖于所述样品中第一分析物的存在而与第一感测电极结合的亲和力; 提供具有附着到具有与第二感测电极结合的构象或亲和力的第二分子（30'，40'，45'）的第二电特征的第二珠（60'），其依赖于第二分子 所述样品中的分析物; 以及分别确定第一感测电极和第二感测电极上的第一磁珠和/或第二磁珠的电特征的存在。 还公开了一种用于实现该方法的IC（10）。 电气签名可以是珠子的尺寸或材料。

公开(公告)号：EP2388337B1

公开(公告)日：2014-07-02

申请号：EP10161670.4

申请日：2010-04-30

Applicant: NXP B.V.

Inventor： Van Steenwinckel, David ,  Frederix, Filip

IPC: C12Q1/68 ,  B01J19/00

CPC classification number: C12Q1/6837 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00653 ,  B01J2219/00722 ,  C40B50/14 ,  C40B50/18 ,  C40B60/12 ,  C12Q2565/518 ,  C12Q2565/607 ,  C12Q2525/197

公开(公告)号：EP2388337A1

公开(公告)日：2011-11-23

申请号：EP10161670.4

申请日：2010-04-30

Applicant: NXP B.V.

Inventor： Van Steenwinckel, David ,  Frederix, Filip

IPC: C12Q1/68 ,  B01J19/00

CPC classification number: C12Q1/6837 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00653 ,  B01J2219/00722 ,  C40B50/14 ,  C40B50/18 ,  C40B60/12 ,  C12Q2565/518 ,  C12Q2565/607 ,  C12Q2525/197

Abstract: The present invention relates to a sensing device comprising a surface having at least one individual sensing region (20), wherein each sensing region comprises a plurality of binding elements (22, 22', 22", 24, 24', 24", 26, 26', 26", 28, 28', 28") anchored on said surface for binding different specific analytes of interest (50, 50'), at least one of the analyte of interest and its matching binding element comprising a label (40) for detecting said binding. The present invention further relates to a method of manufacturing such a sensing device.

Abstract translation: 本发明涉及一种感测装置，其包括具有至少一个单独感测区域（20）的表面，其中每个感测区域包括多个绑定元件（22,22'，22“，24,24'，24”，26 ，26'，26“，28,28'，28”），锚定在所述表面上用于结合不同的感兴趣的特定分析物（50,50'），感兴趣的分析物和其匹配的结合元件中的至少一种包含标签 40）用于检测所述结合。 本发明还涉及一种制造这种感测装置的方法。