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公开(公告)号：US08956647B2
公开(公告)日：2015-02-17
申请号：US13951951
申请日：2013-07-26
Applicant: Norbert Otterbeck , Peter Gruber
Inventor： Norbert Otterbeck , Peter Gruber
CPC classification number: A61K9/0053 , A61K9/141 , A61K9/16 , A61K9/1635 , A61K9/1652 , A61K9/501 , A61K9/5026 , A61K9/5042 , A61K31/60 , A61K31/606
Abstract: An orally administrable pharmaceutical pellet formulation for the treatment of the intestinal tract is disclosed, which comprises a core and an enteric coating, the core including, as a pharmaceutical active compound, aminosalicylic acid or a pharmaceutically tolerable salt or a derivative thereof.
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2.发明授权Budesonide pellets with a controlled released pattern and process for producing the same 失效布地奈德颗粒具有受控的释放模式和其生产方法
公开(公告)号：US5932249A
公开(公告)日：1999-08-03
申请号：US619556
申请日：1996-07-15
Applicant: Peter Gruber , Hans Joachim Lach , Norbert Otterbeck
Inventor： Peter Gruber , Hans Joachim Lach , Norbert Otterbeck
CPC classification number: C12Y304/24 , A61K31/58 , A61K9/5078
Abstract: Disclosed are budesonide pellets with a controlled release pattern containing, from the inside to the outside: a) neutral pellets; b) an active principle layer of micronized budesonide and one or more water-soluble auxiliaries; c) a first lacquer coating consisting of 80 to 97% of at least one lacquer insoluble in gastric fluids but soluble in intestinal fluids and 3 to 20% of at least one lacquer insoluble in both gastric and intestinal fluids; and d) a second lacquer coating consisting of at least one lacquer insoluble in gastric and intestinal fluids. The invention also relates to a process for producing budesonide pellets with a controlled release pattern.
Abstract translation: PCT No.PCT / EP94 / 02531 Sec。 371日期：1996年7月15日 102（e）日期1996年7月15日PCT提交1994年7月29日PCT公布。 公开号WO95 / 08323 日期1995年3月30日公开是具有控制释放模式的布地奈德颗粒，其包含从内到外的：a）中性颗粒; b）微粉化布地奈德和一种或多种水溶性助剂的活性主层; c）第一漆包衣，其由80-97％的至少一种不溶于胃液但可溶于肠液的漆和3至20％至少一种不溶于胃液和肠液的漆组成; 和d）由至少一种不溶于胃液和肠液的漆组成的第二漆层。 本发明还涉及一种具有控制释放模式的布地奈德颗粒的制备方法。
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公开(公告)号：US08911778B2
公开(公告)日：2014-12-16
申请号：US13566905
申请日：2012-08-03
Applicant: Norbert Otterbeck , Peter Gruber
Inventor： Norbert Otterbeck , Peter Gruber
IPC: A61K9/52 , A61K9/56 , A61K9/60 , A61K9/50 , A61K9/16 , A61K9/14 , A61K31/60 , A61K31/606 , A61K9/00
CPC classification number: A61K9/0053 , A61K9/141 , A61K9/16 , A61K9/1635 , A61K9/1652 , A61K9/501 , A61K9/5026 , A61K9/5042 , A61K31/60 , A61K31/606
Abstract: An orally adminsterable pharmaceutical pellet formulation for the treatment of the intestinal tract is disclosed, which comprises a core and an enteric coating, the core including, as a pharmaceutical active compound, aminosalicylic acid or a pharmaceutically tolerable salt or a derivative thereof.
Abstract translation: 公开了一种用于治疗肠道的口服可用药物丸剂制剂，其包含核心和肠溶衣，核心包括作为药物活性化合物的氨基水杨酸或其药学上可耐受的盐或其衍生物。
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4.发明申请公开(公告)号：US20080317848A2
公开(公告)日：2008-12-25
申请号：US10492270
申请日：2004-04-08
Applicant: Thomas Gramatte , Peter Gruber , Michael Heschel , Dirk Pamperin , Jan Ploen , Steffen Scheithauer , Wolfgang Wehner , Peter Guldner
Inventor： Thomas Gramatte , Peter Gruber , Michael Heschel , Dirk Pamperin , Jan Ploen , Steffen Scheithauer , Wolfgang Wehner , Peter Guldner
IPC: A61K31/445 , A61K9/20
CPC classification number: A61K9/2009 , A61K9/2054 , A61K9/2846 , A61K9/5026 , A61K9/5078 , A61K31/445
Abstract: By suitable retardation oral pharmaceutical compositions containing propiverine or one or several pharmaceutically acceptable salts thereof in an amount of 4 mg to 60 mg propiverine and having a prolonged release of the active agent are produced. Preferably a blend of active agent and optionally one or more acidic substances having a pKa value of less than 6.65 are provided with a retarding coating or are embedded in a matrix which is then optionally coated with further retarding layers.
Abstract translation: 通过合适的阻滞剂，可以制备含有丙哌嗪或其一种或多种药学上可接受的盐的药物组合物，其量为4mg至60mg propiverine并且具有延长的活性剂释放。 优选地，具有pKa值小于6.65的活性剂和任选的一种或多种酸性物质的混合物具有延迟涂层或嵌入基质中，然后任选地涂覆有进一步的阻滞层。
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公开(公告)号：US20070246518A1
公开(公告)日：2007-10-25
申请号：US11409233
申请日：2006-04-21
Applicant: Steven Cordes , Peter Gruber , John Knickerbocker , James Speidell
Inventor： Steven Cordes , Peter Gruber , John Knickerbocker , James Speidell
CPC classification number: B23K3/0638 , B23K1/20 , B23K2101/40 , H01L24/11 , H01L24/742 , H01L2224/13099 , H01L2924/01005 , H01L2924/01006 , H01L2924/01018 , H01L2924/01027 , H01L2924/01033 , H01L2924/01042 , H01L2924/01078 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/181 , H01L2924/00
Abstract: A system, method, and apparatus for injection molding conductive bonding material into a plurality of cavities in a surface are disclosed. The method comprises aligning a fill head with a surface. The mold includes a plurality of cavities. The method further includes placing the fill head in substantial contact with the surface. At least a first gas is channeled about a first region of the fill head. The at least first gas has a temperature above a melting point of conductive bonding material residing in a reservoir thereby maintaining the conductive bonding material in a molten state. The conductive bonding material is forced out of the fill head toward the surface. The conductive bonding material is provided into at least one cavity of the plurality of cavities contemporaneous with the at least one cavity being in proximity to the fill head.
Abstract translation: 公开了一种用于将导电接合材料注射成表面中的多个空腔的系统，方法和装置。 该方法包括将填充头与表面对准。 模具包括多个空腔。 该方法还包括将填充头与表面实质接触。 至少第一气体围绕填充头的第一区域引导。 所述至少第一气体具有高于位于储存器中的导电接合材料的熔点的温度，从而将导电接合材料保持在熔融状态。 导电接合材料从表面压出填料头。 导电接合材料被提供到与填充头附近的至少一个空腔同时的多个空腔的至少一个空腔中。
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Patent Agency Ranking
公开(公告)号：US20070246516A1
公开(公告)日：2007-10-25
申请号：US11409242
申请日：2006-04-21
Applicant: Steven Cordes , Peter Gruber , John Knickerbocker , James Speidell
Inventor： Steven Cordes , Peter Gruber , John Knickerbocker , James Speidell
CPC classification number: B23K3/0638 , B23K1/0016 , B23K3/0623 , B23K2101/40 , H01L24/11 , H01L2224/05568 , H01L2224/05573 , H01L2224/11003 , H01L2224/13099 , H01L2924/01005 , H01L2924/01006 , H01L2924/01027 , H01L2924/01033 , H01L2924/01042 , H01L2924/01078 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/181 , H05K3/3478 , H05K3/3484 , H05K2201/09945 , H05K2203/0113 , H05K2203/043 , H01L2924/00
Abstract: A system, method, and device for applying conductive bonding material to a substrate are disclosed. The method includes providing conductive bonding material in a plurality of cavities of a mold. A total number of cavities in the plurality of cavities being greater than a total number of at least one conductive pad of a circuit supporting substrate corresponding to the mold. The conductive bonding material in the mold is heated to a reflow temperature of the conductive bonding material. At least one wettable surface is placed in substantial contact with the heated conductive bonding material in at least one cavity. The mold and the corresponding circuit supporting substrate are brought in close proximity to each other such that the heated conductive bonding material in at least one cavity comes in contact with at least one conductive pad of the corresponding circuit supporting substrate.
Abstract translation: 公开了一种用于将导电接合材料施加到基底的系统，方法和装置。 该方法包括在模具的多个空腔中提供导电接合材料。 多个空腔中的空腔的总数大于对应于模具的电路支撑衬底的至少一个导电焊盘的总数。 将模具中的导电接合材料加热至导电接合材料的回流温度。 在至少一个空腔中至少一个可润湿表面被放置成与被加热的导电接合材料基本接触。 模具和相应的电路支撑衬底彼此靠近，使得至少一个空腔中的加热的导电接合材料与相应的电路支撑衬底的至少一个导电焊盘接触。
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公开(公告)号：US20070029277A1
公开(公告)日：2007-02-08
申请号：US11195147
申请日：2005-08-02
Applicant: Lawrence Jacobowitz , Stephen Buchwalter , Casimer DeCusatis , Peter Gruber , Da-Yuan Shih
Inventor： Lawrence Jacobowitz , Stephen Buchwalter , Casimer DeCusatis , Peter Gruber , Da-Yuan Shih
CPC classification number: H01L27/14685 , B29D11/00365 , B29D11/00461 , B82Y30/00 , G02B3/0018 , G02B3/0056 , G02F1/137 , G02F1/29 , H01L27/14627 , H01L31/02327 , H01L33/58
Abstract: A wafer-scale apparatus and method is described for the automation of forming, aligning and attaching two-dimensional arrays of microoptic elements on semiconductor and other image display devices, backplanes, optoelectronic boards, and integrated optical systems. In an ordered fabrication sequence, a mold plate comprised of optically designed cavities is formed by reactive ion etching or alternative processes, optionally coated with a release material layer and filled with optically specified materials by an automated fluid-injection and defect-inspection subsystem. Optical alignment fiducials guide the disclosed transfer and attachment processes to achieve specified tolerances between the microoptic elements and corresponding optoelectronic devices and circuits. The present invention applies to spectral filters, waveguides, fiber-optic mode-transformers, diffraction gratings, refractive lenses, diffractive lens/Fresnel zone plates, reflectors, and to combinations of elements and devices, including microelectromechanical systems (MEMS) and liquid crystal device (LCD) matrices for adaptive, tunable elements. Preparation of interfacial layer properties and attachment process embodiments are taught.
Abstract translation: 描述了用于在半导体和其他图像显示装置，背板，光电板和集成光学系统上形成，对准和附着微量元件的二维阵列的自动化的晶片级装置和方法。 在有序的制造顺序中，由光学设计的空腔构成的模具板通过反应离子蚀刻或可选的工艺形成，任选地涂覆有释放材料层，并通过自动化流体注入和缺陷检查子系统填充光学特定的材料。 光学校准基准指导所公开的转移和附着过程以实现微光学元件与对应的光电器件和电路之间的特定公差。 本发明适用于光谱滤波器，波导管，光纤模式变压器，衍射光栅，折射透镜，衍射透镜/菲涅耳带片，反射器以及元件和器件的组合，包括微机电系统（MEMS）和液晶器件 （LCD）矩阵，用于自适应，可调元素。 教导界面层性质和附着工艺实施例的制备。
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8.发明申请公开(公告)号：US20060124927A1
公开(公告)日：2006-06-15
申请号：US10905013
申请日：2004-12-09
Applicant: Robert Groves , Peter Gruber , Kevin Petrarca , Richard Volant , George Walker
Inventor： Robert Groves , Peter Gruber , Kevin Petrarca , Richard Volant , George Walker
CPC classification number: H05K3/3468 , G01R1/07314 , G01R3/00 , H01L21/4853 , H01L21/6835 , H01L24/11 , H01L2224/13099 , H01L2224/16225 , H01L2924/00011 , H01L2924/00014 , H01L2924/01013 , H01L2924/01018 , H01L2924/01023 , H01L2924/01029 , H01L2924/01033 , H01L2924/01045 , H01L2924/01047 , H01L2924/01049 , H01L2924/01058 , H01L2924/01066 , H01L2924/01067 , H01L2924/01068 , H01L2924/01075 , H01L2924/01077 , H01L2924/01079 , H01L2924/01082 , H01L2924/01327 , H01L2924/014 , H01L2924/19041 , H01L2924/19042 , H05K3/325 , H05K2201/09745 , H05K2201/10734 , H05K2203/0113 , H05K2203/0338 , H05K2203/128 , H05K2203/162 , H05K2203/167 , H01L2224/0401
Abstract: Methods of forming a conductive structure on a substrate prior to packaging, and a test probe structure generated according to the method, are disclosed. The conductive structure includes a high aspect ratio structure formed by injected molded solder. The invention can be applied to form passive elements and interconnects on a conventional semiconductor substrate after the typical BEOL, and prior to packaging. The method may provide better electromigration characteristics, lower resistivity, and higher Q factors for conductive structures. In addition, the method is backwardly compatible and customizable.
Abstract translation: 公开了在封装之前在基板上形成导电结构的方法和根据该方法生成的测试探针结构。 导电结构包括通过注射成型的焊料形成的高纵横比结构。 本发明可以应用于在典型的BEOL之后以及在封装之前在常规半导体衬底上形成无源元件和互连。 该方法可以为导电结构提供更好的电迁移特性，较低的电阻率和更高的Q因子。 此外，该方法可以向后兼容并可定制。
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公开(公告)号：US5568133A
公开(公告)日：1996-10-22
申请号：US570814
申请日：1995-12-12
Applicant: Bernhard Durrer , Hans Botschi , Peter Gruber
Inventor： Bernhard Durrer , Hans Botschi , Peter Gruber
IPC: G08B17/113 , G08B23/00
CPC classification number: G08B17/113
Abstract: Upon insertion of a fire alarm insert into a corresponding fire alarm mounting, the insert covers the mounting. The insert has a movable fastening comprising a ring, for example, for fastening the insert to the mounting. Indicator elements are included for indicating proper positioning of the insert relative to the mounting.
Abstract translation: 在将火警报警插入物插入相应的火灾报警装置后，插入物将覆盖安装件。 插入件具有可移动的紧固件，其包括例如用于将插入件紧固到安装件上的环。 包括指示元件用于指示插入件相对于安装件的正确定位。
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公开(公告)号：US5364646A
公开(公告)日：1994-11-15
申请号：US33659
申请日：1993-03-16
Applicant: Peter Gruber , Willy Roth , Gottfried Schepky
Inventor： Peter Gruber , Willy Roth , Gottfried Schepky
CPC classification number: A61K31/50 , A61K9/2013 , A61K9/2077 , A61K9/4841 , A61K9/4858 , Y10S514/96 , Y10S514/962
Abstract: Pharmaceutical forms of pimobendan for oral administration comprising citric acid, whereby a constant, satisfactory resorption is ensured even when there are major pH fluctuations in the gastrointestinal tract.
Abstract translation: 用于口服给药的匹莫苯胺的药物形式包括柠檬酸，由此即使当胃肠道中存在主要的pH波动时也确保恒定的令人满意的吸收。
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