公开(公告)号：US20170303800A1

公开(公告)日：2017-10-26

申请号：US15517895

申请日：2014-10-09

Applicant: Novadaq Technologies Inc.

Inventor： Robert W. FLOWER ,  Robert Anthony STEAD ,  Arthur E. BAILEY

IPC: A61B5/026 ,  A61B5/0275 ,  A61B5/00 ,  A61B5/0295

CPC classification number: A61B5/0261 ,  A61B5/00 ,  A61B5/0071 ,  A61B5/0275 ,  A61B5/0295 ,  A61B5/6826

Abstract: A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.

公开(公告)号：US20170245766A1

公开(公告)日：2017-08-31

申请号：US15433502

申请日：2017-02-15

Applicant: Novadaq Technologies Inc.

Inventor： Robert W. FLOWER ,  Robert Anthony STEAD ,  Arthur E. BAILEY

IPC: A61B5/026 ,  A61B5/024 ,  A61B5/00

CPC classification number: A61B5/0261 ,  A61B5/0071 ,  A61B5/02416 ,  A61B5/0275 ,  A61B5/029 ,  A61B5/6826

Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.

公开(公告)号：US20160328848A1

公开(公告)日：2016-11-10

申请号：US15148959

申请日：2016-05-06

Applicant: Novadaq Technologies Inc.

Inventor： Marc ANDRÉ ,  Arthur E. BAILEY ,  Paul Roald WESTWICK

IPC: G06T7/00 ,  H04N1/48 ,  H04N1/60 ,  H04N9/04

CPC classification number: G06T7/0012 ,  A61B5/0059 ,  A61B5/0062 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/445 ,  G01N2021/479 ,  G06T7/90 ,  G06T2207/10004 ,  G06T2207/10024 ,  G06T2207/30104 ,  H04N1/482 ,  H04N1/603 ,  H04N1/6086

Abstract: Methods and systems for imaging tissue of a subject are disclosed, and involve illuminating the tissue with a coherent light having a coherent wavelength, acquiring image data of the tissue using a color image sensor, and processing the image data using laser speckle contrast analysis while correcting for differences in sensitivity of color pixels at the coherent wavelength to generate a perfusion image of the tissue. The perfusion image is then displayed to the user. Also disclosed are methods and systems for correcting for ambient light and for acquiring white light images along with laser speckle images.

Abstract translation: 公开了用于成像对象的组织的方法和系统，并且涉及用具有相干波长的相干光来照射组织，使用彩色图像传感器获取组织的图像数据，以及使用激光散斑对比分析来处理图像数据，同时校正 对于在相干波长处的彩色像素的灵敏度的差异来产生组织的灌注图像。 然后将灌注图像显示给用户。 还公开了用于校正环境光并用于获取白光图像以及激光散斑图像的方法和系统。