公开(公告)号：US20170303800A1

公开(公告)日：2017-10-26

申请号：US15517895

申请日：2014-10-09

Applicant: Novadaq Technologies Inc.

Inventor： Robert W. FLOWER ,  Robert Anthony STEAD ,  Arthur E. BAILEY

IPC: A61B5/026 ,  A61B5/0275 ,  A61B5/00 ,  A61B5/0295

CPC classification number: A61B5/0261 ,  A61B5/00 ,  A61B5/0071 ,  A61B5/0275 ,  A61B5/0295 ,  A61B5/6826

Abstract: A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.

公开(公告)号：US20140371583A1

公开(公告)日：2014-12-18

申请号：US14305950

申请日：2014-06-16

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： Robert W. FLOWER

IPC: A61B5/0275 ,  A61B5/00

CPC classification number: A61B5/0275 ,  A61B5/0071 ,  A61B5/0295 ,  A61B5/6826

Abstract: There is provided a method and a system for quantification of absolute blood flow in tissue using near-infrared fluorescence angiography in conjunction with photoplethysmography (fluorescence-mediated photoplethysmography). The method and system of the present invention provide absolute, real-time measurements of flow in terms of volume/time/area based upon measurement of fluorescence intensity.

Abstract translation: 提供了一种使用近红外荧光血管造影术结合光电体积描记术（荧光介导的光体积描记术）定量组织中绝对血流量的方法和系统。 本发明的方法和系统基于荧光强度的测量提供了在体积/时间/面积方面的流量的绝对的实时测量。

公开(公告)号：US20170245766A1

公开(公告)日：2017-08-31

申请号：US15433502

申请日：2017-02-15

Applicant: Novadaq Technologies Inc.

Inventor： Robert W. FLOWER ,  Robert Anthony STEAD ,  Arthur E. BAILEY

IPC: A61B5/026 ,  A61B5/024 ,  A61B5/00

CPC classification number: A61B5/0261 ,  A61B5/0071 ,  A61B5/02416 ,  A61B5/0275 ,  A61B5/029 ,  A61B5/6826

Abstract: Methods and systems for facilitating assessment of blood flow in a tissue volume of a subject are disclosed. In some variations, the method may include: after a predetermined amount of a fluorescence agent has been administered to the subject, exciting the fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light, acquiring fluorescence data based on the fluorescent light emitted during blood flow through the tissue volume, estimating a molar concentration of the fluorescence agent in the blood flowing through the tissue volume, and generating an assessment of blood flow in the tissue volume based at least in part on the fluorescence data and the estimated molar concentration of the fluorescence agent. The estimated molar concentration may be based on the predetermined amount of the fluorescence agent and an estimated circulating blood volume of the subject.

公开(公告)号：US20150182137A1

公开(公告)日：2015-07-02

申请号：US14510848

申请日：2014-10-09

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： Robert W. FLOWER ,  Robert Anthony Stead ,  Arthur E. Bailey

IPC: A61B5/0275 ,  A61B5/00

CPC classification number: A61B5/0275 ,  A61B5/0071 ,  A61B5/0295 ,  A61B5/6826

Abstract: A method and an apparatus for measuring a time-varying change in an amount of blood in a tissue include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain the measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent.

Abstract translation: 用于测量组织中血液的时变变化的方法和装置包括激发血液中的荧光剂，在通过组织体积的血液的脉动流动期间获取时变光强度信号， 具有类似于常规光谱体积图的收缩期和舒张期的脉动流，并且通过应用修改的Beer-Lambert定律来处理所获取的信号，以获得组织体积中血液量的时变变化的测量。 通过利用荧光剂的荧光发射光谱中的浓度介导的变化来确定荧光剂的瞬时摩尔浓度。

公开(公告)号：US20160199515A1

公开(公告)日：2016-07-14

申请号：US15077677

申请日：2016-03-22

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： Robert W. FLOWER

IPC: A61K49/00

CPC classification number: A61K49/0056 ,  A61K35/76 ,  A61K35/763 ,  A61K47/6901 ,  A61K49/0021 ,  A61K49/0034 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0045 ,  A61K49/0097

Abstract: Disclosed herein is a composition for imaging nerve cells. The composition includes a fluorescent dye; and a viral component including a neurotropic herpes varicellae unable to replicate in nerve cells, a viral protein of a neurotropic herpes varicellae unable to replicate in nerve cells, a capsid of a neurotropic herpes varicellae unable to replicate in nerve cells, or a combination thereof. The fluorescent dye is bound to the viral component to form a dye/viral component complex that is capable of penetrating nerve cells.

Abstract translation: 本文公开了用于成像神经细胞的组合物。 该组合物包括荧光染料; 以及包含不能在神经细胞中复制的神经营养性疱疹性水痘的病毒成分，不能在神经细胞中复制的神经营养性疱疹性水痘病毒的病毒蛋白质，不能在神经细胞中复制的神经营养性疱疹性水痘的衣壳，或其组合。 荧光染料与病毒组分结合形成能够穿透神经细胞的染料/病毒组分复合物。