公开(公告)号：WO1989006162A1

公开(公告)日：1989-07-13

申请号：PCT/US1988004574

申请日：1988-12-21

Applicant: ONCOTECH INCORPORATED

Inventor： ONCOTECH INCORPORATED ,  WEISENTHAL, Larry, M. ,  DUARTE, Thomas, Edward ,  NAGOURNEY, Robert, A.

IPC: B04B05/02

CPC classification number: G01N33/5011 ,  B01L3/5021 ,  B04B5/0414 ,  G01N1/2813 ,  G01N2800/52

Abstract: An improved method for predicting success of tumor therapies which relies on estimating the lowest effective concentration of a therapeutic agent that results in a majority of tumor cell kill in vitro is described. The method includes an assay and apparatus for simultaneously analyzing a series of dilutions of a therapeutic agent using 90 % cell kill as an index to effective cytotoxic concentration of the agent.

Abstract translation: 描述了一种用于预测肿瘤治疗成功的改进方法，其依赖于估计在体外导致大部分肿瘤细胞杀伤的治疗剂的最低有效浓度。 该方法包括用于同时分析治疗剂的一系列稀释液的测定和装置，其使用90％细胞杀伤作为试剂的有效细胞毒性浓度的指标。

公开(公告)号：WO1989003995A1

公开(公告)日：1989-05-05

申请号：PCT/US1988003783

申请日：1988-10-25

Applicant: ONCOTECH INCORPORATED

Inventor： ONCOTECH INCORPORATED ,  WEISENTHAL, Larry, M.

IPC: G01N33/53

CPC classification number: G01N33/5011 ,  G01N33/574

Abstract: A method for detecting the sensitivity of tumor cells to immune effectors uses an assay that distinguishes living tumor cells from dead cells in mixed populations of cells. Acquired resistance to immune effectors used in therapy may be determined and used to identify methods to circumvent such resistance using the method.