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    DEVICE FOR MINIMIZING OUTGASSING FROM FLUID
    1.
    发明申请
    DEVICE FOR MINIMIZING OUTGASSING FROM FLUID 审中-公开
    从流体中最小化出口的装置

    公开(公告)号：WO1998001752A1

    公开(公告)日：1998-01-15

    申请号：PCT/US1997011863

    申请日：1997-07-07

    Applicant: OPTICAL SENSORS INCORPORATED

    Inventor： OPTICAL SENSORS INCORPORATED ,  KIMBALL, Victor, E. ,  PIERSKALLA, Irvin, T. ,  ANDERSON, Edward, J.

    IPC: G01N33/48

    CPC classification number: B65D75/38 ,  B65D81/2061

    Abstract: A device (10) is provided for minimizing outgassing of a gas dissolved in a fluid at a predetermined partial pressure. The device includes a first pouch (12) containing the fluid (18) and a compressing means (14, 42, 42', 52, 52') for subjecting the first pouch to greater-than-ambient pressure. Methods are also provided for using the device to minimize outgassing.

    Abstract translation: 提供了一种用于使预定分压下溶解在流体中的气体的除气最小化的装置（10）。 该装置包括容纳流体（18）的第一袋（12）和用于使第一袋经受大于环境压力的压缩装置（14,42'，52'，52,52'）。 还提供了使用该装置以最小化除气的方法。

    SIMULTANEOUS DUAL EXCITATION/SINGLE EMISSION FLUORESCENT SENSING METHOD FOR pH AND pCO2
    2.
    发明申请
    SIMULTANEOUS DUAL EXCITATION/SINGLE EMISSION FLUORESCENT SENSING METHOD FOR pH AND pCO2 审中-公开
    用于pH和pCO2的同时双激发/单发射荧光感测方法

    公开(公告)号：WO1997010495A1

    公开(公告)日：1997-03-20

    申请号：PCT/US1996013791

    申请日：1996-08-27

    Applicant: OPTICAL SENSORS INCORPORATED

    Inventor： OPTICAL SENSORS INCORPORATED ,  FURLONG, Steven, C.

    IPC: G01N21/64

    CPC classification number: G01N21/643 ,  G01N21/7703 ,  G01N33/84 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7759 ,  G01N2021/7786 ,  G01N2201/062 ,  Y10T436/204998

    Abstract: A simultaneous dual excitation/single emission ratiometric method using fiber optic sensors is provided for detecting or measuring a parameter of interest in a sample, including pH, concentration of gases such as CO2, and the like. The method involves simultaneously providing modulated optical light corresponding to first and second regions of an indicator species' absorption or excitation spectrum, detecting modulated emission signals from the indicator species, demodulating the emission signals, calculating the apparent quantity of analyte present in the sample from the indicator emission signals and correcting the apparent quantity of analyte present for variations resulting from external factors, by determining the ratio of the demodulated indicator emission signals. An apparatus is provided for performing the method as well.

    Abstract translation: 提供了使用光纤传感器的同时双激发/单发射比例法，用于检测或测量样品中感兴趣的参数，包括pH，诸如CO 2等气体的浓度。 该方法包括同时提供对应于指示物种吸收或激发光谱的第一和第二区域的调制光学光，检测来自指示物质的调制的发射信号，解调发射信号，计算从样品中存在的分析物的表观量 指示符发射信号，并且通过确定解调的指示符发射信号的比率来校正存在的用于由外部因素引起的变化的分析物的表观量。 提供了一种用于执行该方法的装置。

    OPTICAL CARBON DIOXIDE SENSOR, AND ASSOCIATED METHODS OF MANUFACTURE AND USE
    4.
    发明申请
    OPTICAL CARBON DIOXIDE SENSOR, AND ASSOCIATED METHODS OF MANUFACTURE AND USE 审中-公开
    光学二氧化碳传感器及相关的制造和使用方法

    公开(公告)号：WO1997012227A1

    公开(公告)日：1997-04-03

    申请号：PCT/US1996015353

    申请日：1996-09-25

    Applicant: OPTICAL SENSORS INCORPORATED

    Inventor： OPTICAL SENSORS INCORPORATED ,  ALDERETE, Jason, E. ,  OLSTEIN, Alan, D. ,  FURLONG, Steven, C.

    IPC: G01N21/64

    CPC classification number: G01N21/643 ,  G01N21/7703 ,  G01N21/783 ,  G01N21/80 ,  G01N31/223 ,  G01N33/004 ,  G01N2021/6432 ,  G01N2021/7786

    Abstract: A method is provided for manufacturing a fiber optic sensor for detecting or measuring the concentration of carbon dioxide in a sample fluid. The method involves preparation of a suitable indicator composition (16) and incorporation thereof in a silicone capsule (14) slidably arranged over the tip of a fiber optic (12), sealed with a suitable adhesive means (18). To amplify the signal obtained, the capsule (14) is preferably fabricated so as to contain reflective particules, and tapers to a narrow tip. Novel optical sensors are also provided, as are methods for using the sensors to evaluate CO2 concentration in a sample fluid.

    Abstract translation: 提供了一种用于制造用于检测或测量样品流体中二氧化碳浓度的光纤传感器的方法。 该方法包括制备合适的指示剂组合物（16）并将其结合到可滑动地布置在光纤（12）的尖端上的硅胶囊（14）中，用合适的粘合剂装置（18）密封。 为了放大所获得的信号，胶囊（14）优选地被制造成包含反射微粒，并且变窄到窄尖端。 还提供了新的光学传感器，以及使用传感器来评估样品流体中的CO 2浓度的方法。

    A RATIOMETRIC FLUORESCENCE METHOD TO MEASURE OXYGEN
    5.
    发明申请
    A RATIOMETRIC FLUORESCENCE METHOD TO MEASURE OXYGEN 审中-公开
    测量氧气的比例荧光法

    公开(公告)号：WO1995008107A1

    公开(公告)日：1995-03-23

    申请号：PCT/US1994010139

    申请日：1994-09-07

    Applicant: OPTICAL SENSORS INCORPORATED

    Inventor： OPTICAL SENSORS INCORPORATED ,  KANE, James ,  MARTIN, Roy ,  SCHILLING, Anne

    IPC: G01N21/63

    CPC classification number: G01N21/643 ,  G01N21/7703 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7786 ,  Y10T436/207497 ,  Y10T436/209163

    Abstract: A ratiometric method for using optical sensors (11) is provided to measure dissolved oxygen in a fluid sample. The sensor (11) is formulated so as to contain an oxygen permeable membrane (16) of a cured perfluorinated urethane polymer and, incorporated therein, an oxygen-sensitive indicator component and a reference dye component. The emission spectrum from the indicator component is calibrated by comparison with that of the reference dye, which is substantially less sensitive to oxygen-quenching and which has a photodecomposition rate similar to the indicator component. Methods for making and using the membrane and sensor (11) are provided as well.

    Abstract translation: 提供了使用光学传感器（11）的比例计方法来测量流体样品中的溶解氧。 将传感器（11）配制为包含固化的全氟化氨基甲酸酯聚合物的透氧膜（16），并且其中并入氧敏指示剂组分和参考染料组分。 通过与参考染料的比较来校准来自指示剂组分的发射光谱，其对氧气淬灭基本上较不敏感，并且具有与指示剂组分相似的光分解速率。 还提供了制造和使用膜和传感器（11）的方法。

    PACKAGE FOR MAINTAINING A DISSOLVED GAS
    6.
    发明申请
    PACKAGE FOR MAINTAINING A DISSOLVED GAS 审中-公开
    用于维护溶解气体的包装

    公开(公告)号：WO1998001365A1

    公开(公告)日：1998-01-15

    申请号：PCT/US1997008795

    申请日：1997-05-21

    Applicant: OPTICAL SENSORS INCORPORATED

    Inventor： OPTICAL SENSORS INCORPORATED ,  KIMBALL, Victor, E. ,  PIERSKALLA, Irvin, T. ,  PORTER, Christopher, H.

    IPC: B65D81/28

    CPC classification number: A61J1/10 ,  A61J1/16 ,  B65D75/38 ,  B65D81/2084

    Abstract: A device (10) is provided for maintaining a volume of gas dissolved in a fluid (18) at a predetermined partial pressure. The device includes a first sealable, gas-tight pouch (12) containing the fluid and a second sealable, gas-tight pouch (14) encasing the first pouch and providing a space (16) between the first and second pouches. The space may be charged with an atmosphere containing a volume of the gas dissolved in the fluid that is greater than the volume of dissolved gas, at a partial pressure that is substantially the same as the partial pressure of the dissolved gas. A method is also provided for using the device to maintain a volume of a gas dissolved in a fluid at a predetermined partial pressure.

    Abstract translation: 提供了一种装置（10），用于以预定分压保持溶解在流体（18）中的气体体积。 该装置包括容纳流体的第一可密封的气密袋（12）和封装第一袋的第二可密封的气密袋（14），并且在第一和第二袋之间提供空间（16）。 该空间可以以与溶解气体的分压基本相同的分压，装入溶解在流体中的体积大于溶解气体的体积的气体。 还提供了一种使用该装置以在预定分压保持溶解在流体中的气体体积的方法。

    IN SITU CALIBRATION SYSTEM FOR SENSORS LOCATED IN A PHYSIOLOGIC LINE
    7.
    发明申请
    IN SITU CALIBRATION SYSTEM FOR SENSORS LOCATED IN A PHYSIOLOGIC LINE 审中-公开
    用于位于生理线路中的传感器的现场校准系统

    公开(公告)号：WO1996022730A1

    公开(公告)日：1996-08-01

    申请号：PCT/US1996000866

    申请日：1996-01-24

    Applicant: OPTICAL SENSORS INCORPORATED

    Inventor： OPTICAL SENSORS INCORPORATED ,  KIMBALL, Victor, E. ,  LYNCH, Laurie, E. ,  PIERSKALLA, Irvin, T. ,  PORTER, Christopher, H.

    IPC: A61B05/05

    CPC classification number: A61B5/157 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150992 ,  A61B5/155

    Abstract: A method is provided for calibrating sensors (14) used to analyze characteristics of physiologic fluids such as blood. The method involves the use of a sensor assembly (12) having an analyte responsive sensor (14) in communication with a physiologic line (28) and a conduit passageway (16). The method involves exposing the sensor (14) to a reference sample, thereby producing a sensor response. The method also allows performing quality control on sensors (14). Also provided is an apparatus (10) with which the claimed method may be practiced.

    Abstract translation: 提供了一种用于校准用于分析生理液体如血液的特征的传感器（14）的方法。 该方法涉及使用具有与生理线路（28）和导管通道（16）连通的分析物响应传感器（14）的传感器组件（12）。 该方法包括将传感器（14）暴露于参考样品，从而产生传感器响应。 该方法还允许对传感器（14）执行质量控制。 还提供了可以实施所要求保护的方法的装置（10）。

    OPTICAL SENSORS FOR MEASURING pH IN FLUIDS
    8.
    发明申请
    OPTICAL SENSORS FOR MEASURING pH IN FLUIDS 审中-公开
    用于测量流体中pH值的光学传感器

    公开(公告)号：WO1994028786A1

    公开(公告)日：1994-12-22

    申请号：PCT/US1994006258

    申请日：1994-06-02

    Applicant: OPTICAL SENSORS INCORPORATED

    Inventor： OPTICAL SENSORS INCORPORATED ,  OLSTEIN, Alan ,  FOWLER, William ,  PRITCHARD, Jo

    IPC: A61B05/00

    CPC classification number: G01N21/7703 ,  G01N21/6428 ,  G01N21/80 ,  G01N33/84 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2021/773 ,  G01N2021/7786

    Abstract: An optical sensor is provided for measuring the pH of a fluid sample. The sensor is formulated using a fluorescent polymer composition comprising a copolymer of a water-dispersable, polyether-containing urethane olefin precursor and a fluorescent monomer species, wherein the ratio of precursor and fluorescent monomer species is such that a predetermined apparent pKa is provided. The sensor is prepared by coating the distal end of an optical waveguide with the fluorescent polymer composition, and curing the copolymer contained in the composition, e.g., by exposure to radiation of a suitable wavelength.

    Abstract translation: 提供了用于测量流体样品的pH的光学传感器。 使用包含可水分散性聚醚的聚氨酯烯烃前体和荧光单体种类的共聚物的荧光聚合物组合物来配制传感器，其中前体和荧光单体种类的比例使得提供预定的表观pKa。 通过用荧光聚合物组合物涂覆光波导的远端并且例如通过暴露于合适波长的辐射来固化包含在组合物中的共聚物来制备传感器。

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