公开(公告)号：WO1996039922A1

公开(公告)日：1996-12-19

申请号：PCT/US1996004502

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： OPTIX LP ,  BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: A61B05/00

CPC classification number: A61B5/14532 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/14558 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/3137

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.

Abstract translation: 已经开发了用于样品中浓度的光学测试的改进的方法和装置。 该装置限制了立体照明角度和立体检测角度，以消除散射辐射的高比例，同时允许弹道辐射和蛇状辐射传播。 在包含多个散射中心的样品中，这样可有效地校正光束长度的变化，并允许更容易校准仪器。 还公开了使用偏振辐射作为使样品中的散射辐射最小化的手段。 在第二实施例中，检测器仅收集偏振辐射，同时排除去极化（多散射）辐射。 辐射优选地选择在700-1500nm波长范围内。 样品优选地是哺乳动物体的一部分，待分析的分析物选自葡萄糖，葡萄糖鉴定物质，其混合物或由血红蛋白，脱氧血红蛋白及其混合物组成的组。 浓度测量可用于导出血液的氧饱和度。

公开(公告)号：EP0742897A1

公开(公告)日：1996-11-20

申请号：EP95907352.0

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: A61B5 ,  G01N21 ,  G01N33

CPC classification number: G01N21/4795 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/359 ,  G01N2021/3137

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distinguishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer can be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.

公开(公告)号：EP0742897B1

公开(公告)日：2003-04-09

申请号：EP95907352.9

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: G01N21/35

CPC classification number: G01N21/4795 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  G01N21/359 ,  G01N2021/3137

公开(公告)号：EP0884970A1

公开(公告)日：1998-12-23

申请号：EP96910703.0

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: G01N21 ,  A61B5 ,  A61B10 ,  G01N33

CPC classification number: A61B5/14532 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/14558 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/3137

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.