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    NON-INVASIVE NON-SPECTROPHOTOMETRIC INFRARED MEASUREMENT OF BLOOD ANALYTE CONCENTRATIONS
    2.
    发明专利
    NON-INVASIVE NON-SPECTROPHOTOMETRIC INFRARED MEASUREMENT OF BLOOD ANALYTE CONCENTRATIONS 未知

    公开(公告)号：CA2180128A1

    公开(公告)日：1995-07-20

    申请号：CA2180128

    申请日：1995-01-09

    Applicant: OPTIX LP

    Inventor： BLOCK MYRON J ,  SODICKSON LESTER

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

    Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distinguishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer cam be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.

    3.
    发明专利
    未知

    公开(公告)号：DE69530284T2

    公开(公告)日：2004-01-29

    申请号：DE69530284

    申请日：1995-01-09

    Applicant: OPTIX LP

    Inventor： BLOCK MYRON J ,  SODICKSON LESTER

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

    Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. The apparatus and methods of the invention exploit analogies with colorimetry and color perception to extract concentration measurements from the global structure of the intensity versus wavelength absorbance or transmission profile. A plurality of broad spectrum filters transmit distinguishably coded beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer can be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.

    NON-INVASIVE NON-SPECTROPHOTOMETRIC INFRARED MEASUREMENT OF BLOOD ANALYTE CONCENTRATIONS
    5.
    发明专利
    NON-INVASIVE NON-SPECTROPHOTOMETRIC INFRARED MEASUREMENT OF BLOOD ANALYTE CONCENTRATIONS 未知

    公开(公告)号：CA2180128C

    公开(公告)日：2004-06-29

    申请号：CA2180128

    申请日：1995-01-09

    Applicant: OPTIX LP

    Inventor： SODICKSON LESTER ,  BLOCK MYRON J

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

    Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of ana- lytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distin- guishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interfer- ometer cam be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by anal- ogy to colorimetry and visual processing and can be converted into concentration measurements.

    METHODS OF MINIMIZING SCATTERING AND IMPROVING TISSUE SAMPLING IN NON-INVASIVE TESTING AND IMAGING
    7.
    发明专利
    METHODS OF MINIMIZING SCATTERING AND IMPROVING TISSUE SAMPLING IN NON-INVASIVE TESTING AND IMAGING 未知

    公开(公告)号：CA2223408A1

    公开(公告)日：1996-12-19

    申请号：CA2223408

    申请日：1996-04-02

    Applicant: OPTIX LP

    Inventor： SODICKSON LESTER ,  BLOCK MYRON J

    IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B10/00 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487 ,  A61B6/00

    Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.

    8.
    发明专利
    未知

    公开(公告)号：ES2194048T3

    公开(公告)日：2003-11-16

    申请号：ES95907352

    申请日：1995-01-09

    Applicant: OPTIX LP

    Inventor： BLOCK MYRON J ,  SODICKSON LESTER

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

    Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. The apparatus and methods of the invention exploit analogies with colorimetry and color perception to extract concentration measurements from the global structure of the intensity versus wavelength absorbance or transmission profile. A plurality of broad spectrum filters transmit distinguishably coded beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer can be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.

    9.
    发明专利
    未知

    公开(公告)号：DE69530284D1

    公开(公告)日：2003-05-15

    申请号：DE69530284

    申请日：1995-01-09

    Applicant: OPTIX LP

    Inventor： BLOCK MYRON J ,  SODICKSON LESTER

    IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

    Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. The apparatus and methods of the invention exploit analogies with colorimetry and color perception to extract concentration measurements from the global structure of the intensity versus wavelength absorbance or transmission profile. A plurality of broad spectrum filters transmit distinguishably coded beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer can be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.

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