Patent search ap:("OSIRIS THERAPEUTICS Page INC.") AND inv:"DHALL

1.

发明申请
PRIMED PLACENTAL TISSUE AND USES IN REGENERATIVE MEDICINE 审中-公开

公开(公告)号：WO2022074523A1

公开(公告)日：2022-04-14

申请号：PCT/IB2021/059024

申请日：2021-09-30

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： LI, Chaoyang , JACOB, Vimal , PARK, Min Sung , DHALL, Sandeep , SATHYAMOORTHY, Malathi

IPC: A61K35/50 , A61K35/51 , A61P17/02

Abstract: Disclosed are methods and compositions useful for regenerative medicine for the therapeutic regeneration and repair of cells, tissues, or organs. The present disclosure relates to methods of priming viable placental tissue, primed viable placental tissue, and products thereof. Various priming techniques are disclosed including exposure viable placental tissue to hypoxia, UV light, bioactive materials, or combinations thereof.

2.

发明申请
HUMAN TISSUE DERIVED COMPOSITIONS AND USES THEREOF 审中-公开

公开(公告)号：WO2021183851A1

公开(公告)日：2021-09-16

申请号：PCT/US2021/022059

申请日：2021-03-12

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： SINCLAIR, Steven Michael , DANILKOVITCH, Alla , SATHYAMOORTHY, Malathi , KUANG, Jin-qiang , DHALL, Sandeep , LIU, Yishan , MELCHIORRI, Anthony John , MOORMAN, Matthew Robert , SCHIANO LO MORIELLO, Mena , ALLGOOD LERCH, Anne

IPC: A61K9/00 , A61K9/06 , A61K35/33 , A61K35/50 , A61K35/51 , A61P17/02 , A61P19/00 , A61P29/00

Abstract: Disclosed are compositions comprising a minced chorionic matrix, a homogenized amniotic matrix, and a homogenized umbilical cord (UC) matrix, wherein the minced chorionic matrix comprises viable cells, wherein the composition does not comprise trophoblasts. Disclosed are compositions comprising isolated, viable chorionic cells, a homogenized amniotic matrix, and a homogenized UC matrix, wherein the composition does not comprise trophoblasts. Disclosed are compositions comprising a minced chorionic matrix and a homogenized UC matrix, wherein the minced chorionic matrix comprises viable cells, wherein the composition does not comprise trophoblasts or an amniotic matrix. Disclosed are compositions comprising isolated, viable chorionic cells and a homogenized UC matrix, wherein the composition does not comprise trophoblasts or an amniotic matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.

3.

发明申请
HUMAN TISSUE DERIVED COMPOSITIONS AND USES THEREOF 审中-公开
Title translation: 人体组织衍生组合物及其用途

公开(公告)号：WO2017223494A1

公开(公告)日：2017-12-28

申请号：PCT/US2017/039075

申请日：2017-06-23

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： SINCLAIR, Steven Michael , DANILKOVITCH, Alla , SATHYAMOORTHY, Malathi , KUANG, Jin-Qiang , DHALL, Sandeep , LIU, Yishan , MELCHIORRI, Anthony John , MOORMAN, Matthew Robert , LO MORIELLO, Mena Schiano , LERCH, Anne Allgood

IPC: A61K35/50 , A61K38/57 , A61K31/717 , A61K31/722 , A61K31/728 , A61K31/731 , C12N5/073 , A01N1/02

Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non- homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.

Abstract translation: 公开了包含非均质绒毛膜基质，均质羊膜基质和均质UC（UC）基质的组合物，其中所述非匀浆绒毛膜基质包含活细胞。公开了制备本文公开的组合物的方法，其包括制备非匀浆绒毛膜基质，制备匀浆羊膜基质，制备匀浆UC基质，并将非匀浆绒毛膜基质，非匀浆绒毛膜基质和匀浆UC 矩阵。公开了治疗组织损伤或慢性疼痛的方法，其包括将任何公开的组合物施用至包含组织损伤的受试者的区域。

4.

发明申请
VIABLE LYOPHILIZED COMPOSITIONS DERIVED FROM HUMAN TISSUES AND METHODS OF MAKING THE SAME 审中-公开
Title translation: 来自人体组织的可渗透冻干组合物及其制备方法

公开(公告)号：WO2017223520A1

公开(公告)日：2017-12-28

申请号：PCT/US2017/039123

申请日：2017-06-23

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： SINCLAIR, Steven Michael , DANILKOVITCH, Alla , SATHYAMOORTHY, Malathi , KUANG, Jin-Qiang , DHALL, Sandeep , MELCHIORRI, Anthony John

IPC: A01N1/02 , A61F2/10 , A61F2/28 , A61L27/36 , A61L27/38 , A61L27/54

Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.

Abstract translation: 公开了冻干组织样品的方法，包括获得组织样品，使组织样品与冻干保护剂溶液接触，冷冻组织样品，冷冻后进行组织样品的第一干燥步骤，在第一干燥步骤之后的组织样本的第二干燥步骤。公开了使用冻干组织样品的公开方法制备的冻干组织，包括获得组织样品，使组织样品与冻干保护剂溶液接触，冷冻组织样品，冷冻后进行组织样品的第一干燥步骤，在第一干燥步骤之后干燥组织样品的步骤。公开了治疗伤口或组织缺损的方法，包括将重建的冻干组织施用于伤口或组织缺陷。