公开(公告)号：US20240165166A1

公开(公告)日：2024-05-23

申请号：US18043064

申请日：2021-09-30

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Chaoyang LI ,  Vimal JACOB ,  Min Sung PARK ,  Sandeep DHALL ,  Malathi SATHYAMOORTHY

IPC: A61K35/50 ,  A61K35/51 ,  A61P9/10 ,  A61P17/02

CPC classification number: A61K35/50 ,  A61K35/51 ,  A61P9/10 ,  A61P17/02

Abstract: Disclosed are methods and compositions useful for regenerative medicine for the therapeutic regeneration and repair of cells, tissues, or organs. The present disclosure relates to methods of priming viable placental tissue, primed viable placental tissue, and products thereof. Various priming techniques are disclosed including exposure viable placental tissue to hypoxia, UV light, bioactive materials, or combinations thereof.

公开(公告)号：US20220202876A1

公开(公告)日：2022-06-30

申请号：US17698490

申请日：2022-03-18

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Steven Michael SINCLAIR ,  Alla DANILKOVITCH ,  Malathi SATHYAMOORTHY ,  Jin-Qiang KUANG ,  Sandeep DHALL ,  Anthony John MELCHIORRI

IPC: A61K35/50 ,  A01N1/02 ,  A61F13/00 ,  A61L27/36 ,  A61K9/16 ,  A61K9/19 ,  A61K35/32 ,  A61K35/36

Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.

公开(公告)号：US20230047934A1

公开(公告)日：2023-02-16

申请号：US17788939

申请日：2021-03-12

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael SINCLAIR ,  Alla DANILKOVITCH ,  Malathi SATHYAMOORTHY ,  Jin-Qiang KUANG ,  Sandeep DHALL ,  Yishan LIU ,  Anthony John MELCHIORRI ,  Matthew Robert MOORMAN ,  Mena Schiano LO MORIELLO ,  Anne Allgood LERCH

IPC: A61K35/50 ,  A61K35/33 ,  A61K35/51 ,  A61K9/19 ,  A61K9/00

Abstract: Disclosed are compositions comprising a minced chorionic matrix, a homogenized amniotic matrix, and a homogenized umbilical cord (UC) matrix, wherein the minced chorionic matrix comprises viable cells, wherein the composition does not comprise trophoblasts. Disclosed are compositions comprising isolated, viable chorionic cells, a homogenized amniotic matrix, and a homogenized UC matrix, wherein the composition does not comprise trophoblasts. Disclosed are compositions comprising a minced chorionic matrix and a homogenized UC matrix, wherein the minced chorionic matrix comprises viable cells, wherein the composition does not comprise trophoblasts or an amniotic matrix. Disclosed are compositions comprising isolated, viable chorionic cells and a homogenized
UC matrix, wherein the composition does not comprise trophoblasts or an amniotic matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.

公开(公告)号：US20250161370A1

公开(公告)日：2025-05-22

申请号：US19027897

申请日：2025-01-17

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael SINCLAIR ,  Alla DANILKOVITCH ,  Malathi SATHYAMOORTHY ,  Jin-Qiang KUANG ,  Sandeep DHALL ,  Yishan LIU ,  Anthony John MELCHIORRI ,  Matthew Robert MOORMAN ,  Mena Schiano LO MORIELLO ,  Anne Allgood LERCH

IPC: A61K35/50 ,  A61K9/00 ,  A61K9/06 ,  A61K9/19 ,  A61K35/33 ,  A61K35/51 ,  A61L26/00 ,  A61L27/36 ,  A61L27/38 ,  A61P17/02 ,  A61P19/00 ,  A61P19/02 ,  A61P19/04 ,  A61P19/10 ,  A61P29/00

Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.