公开(公告)号：US20220016180A1

公开(公告)日：2022-01-20

申请号：US17400864

申请日：2021-08-12

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Alla DANILKOVITCH ,  Yi DUAN-ARNOLD ,  Matthew MOORMAN ,  Anne LERCH ,  Jin-Qiang KUANG

IPC: A61K35/51 ,  A61K35/50 ,  A01N1/02

Abstract: Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.