公开(公告)号：US20220202991A1

公开(公告)日：2022-06-30

申请号：US17698602

申请日：2022-03-18

Applicant: OSIRIS THERAPEUTICS, INC.

Inventor： Thomas E. UVEGES ,  Jin-Qiang KUANG ,  Alla DANILKOVITCH ,  S. Michael SINCLAIR ,  Sandra D. GERAGHTY

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61K38/18

Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.

公开(公告)号：US20210023268A1

公开(公告)日：2021-01-28

申请号：US17039402

申请日：2020-09-30

Applicant: Osiris Therapeutics, Inc.

Inventor： Thomas E. UVEGES ,  Jin-Qiang KUANG ,  Alla DANILKOVITCH ,  S. Michael SINCLAIR ,  Sandra D. GERAGHTY

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61K38/18

Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.

公开(公告)号：US20170035935A1

公开(公告)日：2017-02-09

申请号：US15298142

申请日：2016-10-19

Applicant: Osiris Therapeutics, Inc.

Inventor： Thomas E. UVEGES ,  Jin-Qiang KUANG ,  Alla DANILKOVITCH ,  S. Michael SINCLAIR ,  Sandra D. GERAGHTY

IPC: A61L27/36 ,  A61L27/38 ,  A61K38/18 ,  A61L27/54

Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.

Abstract translation: 本文提供了一种骨修复组合物，其由含有血管生成生长因子的骨膜，含有活的成骨细胞的松质骨碎片和任选的软化骨基质（DBM）芯片组成。 本文还提供了治疗骨缺损的制品及其使用方法。