公开(公告)号：AU2021222009A1

公开(公告)日：2022-09-15

申请号：AU2021222009

申请日：2021-02-18

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： KURITSYN ALEXEY ,  MCDONALD MARK ,  RULISON AARON ,  GROT ANNETTE

IPC: G02B6/12 ,  C12Q1/6874 ,  G01N21/00 ,  G01N21/17 ,  G01N21/63 ,  G01N21/78

Abstract: Provided herein are highly multiplexed optical analytical systems for improved nucleic acid sequencing. The systems include a plurality of highly multiplexed optical chips, at least one optical source, and a plurality of optical delivery devices for illuminating an array of nanoscale rection regions on each of the optical chips. In use, the reaction regions contain fluorescent nucleic acid sequencing reagents and are arranged to report nucleic acid sequence information to optical detectors associated with the multiplexed optical chips in real time. The systems enable a massive increase in the scale of nucleic acid sequencing reactions capable of being performed within a single instrument without a corresponding increase in size, complexity, or cost of the instrument.