公开(公告)号：AU2009204461A1

公开(公告)日：2009-07-16

申请号：AU2009204461

申请日：2009-01-09

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： TURNER STEPHEN ,  LYLE JOHN ,  LUONG KHAI ,  DALAL RAVI ,  LUNDQUIST PAUL

IPC: G01N21/64 ,  G01N21/00

Abstract: Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.

公开(公告)号：EP3183367A4

公开(公告)日：2018-04-11

申请号：EP15834113

申请日：2015-08-19

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： TSAI YU CHIH ,  VILFAN IGOR DRASKO ,  LUONG KHAI

IPC: C12Q1/68 ,  C12N9/22 ,  C12N15/09 ,  C12N15/11

CPC classification number: C12N15/63 ,  C12N9/16 ,  C12N15/66 ,  C12Q1/6806 ,  C12Q2525/191 ,  C40B40/06 ,  C40B40/08 ,  C40B50/06 ,  C12Q2521/301

Abstract: Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis. The methods result in a subset of the initial population enriched for a target region, which is typically located within one or more target fragments. The methods are particularly useful for analyzing populations having a high degree of complexity, e.g., chromosomal-derived DNA, whole genomic DNA, or mRNA populations.