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    Methods and systems for analyzing fluorescent materials with reduced autofluorescence
    3.
    发明专利
    Methods and systems for analyzing fluorescent materials with reduced autofluorescence 未知

    公开(公告)号：AU2008251861B2

    公开(公告)日：2014-03-20

    申请号：AU2008251861

    申请日：2008-05-09

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： ZHONG CHENG-FRANK ,  ZHAO PEIQIAN ,  LUNDQUIST PAUL ,  TURNER STEPHEN ,  ZACCARIN DENIS

    IPC: G01N21/76 ,  G01N24/00

    Abstract: Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high- density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.

    COMPOSICIONES Y METODOS PARA SECUENCIACION DE ACIDOS NUCLEICOS.
    6.
    发明专利
    COMPOSICIONES Y METODOS PARA SECUENCIACION DE ACIDOS NUCLEICOS. 未知

    公开(公告)号：MX2010010600A

    公开(公告)日：2011-03-30

    申请号：MX2010010600

    申请日：2009-03-27

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： TURNER STEPHEN ,  TRAVERS KEVIN ,  OTTO GEOFF ,  HEINER CHERYL ,  MA CONGCONG

    IPC: C12Q1/68

    Abstract: Se describen composiciones y métodos para secuenciación de ácido nucleico que incluyen constructos de plantilla que comprenden porciones de doble hebra en constructos parcial o completamente contiguos, para proveer determinación de secuencia redundante por medio de una o ambas de secuenciación de hebras de sentido y anti-sentido y secuenciación iterativamente de todo el constructo múltiples veces. Componentes de secuencia adicionales son también incluidos opcionalmente dentro de tales constructos de plantilla. También se proveen métodos para el uso y preparación de estos constructor, también corno composiciones de secuenciación para su aplicación.

    COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING
    10.
    发明专利
    COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING 未知

    公开(公告)号：CA2719747C

    公开(公告)日：2018-02-20

    申请号：CA2719747

    申请日：2009-03-27

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： TRAVERS KEVIN ,  OTTO GEOFF ,  TURNER STEPHEN ,  HEINER CHERYL ,  MA CONGCONG

    IPC: C12Q1/68 ,  C12Q1/6869

    Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.

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