公开(公告)号：CA2201428A1

公开(公告)日：1996-04-11

申请号：CA2201428

申请日：1995-10-02

Applicant: PATHOGENESIS CORP

Inventor： STOVER CHARLES KENDALL ,  HICKEY MARK JEFFREY

IPC: C12N9/02 ,  C12N15/74 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/6897 ,  C12N1/21 ,  C12Q1/66

Abstract: This invention relates to a method of quantifying bacteria in vivo or in vitro using bacterial reporter strains. In particular this invention provides a method utilizing mycobacterial reporter strains that permits rapid screening for in vivo antimycobacterial activity of various compositions. In addition this invention provides for particular mycobacterial reporter strains expressing the FFlux gene at levels sufficiently high to allow detection in tissue homogenates without lysis or concentration of the bacteria.

公开(公告)号：EP0784700A4

公开(公告)日：1999-09-01

申请号：EP95935267

申请日：1995-10-02

Applicant: PATHOGENESIS CORP

Inventor： STOVER KENDALL ,  HICKEY MARK JEFFREY

IPC: C12N9/02 ,  C12N15/74 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/66 ,  C12N1/20

CPC classification number: C12N9/0069 ,  C12N15/74 ,  C12Q1/02 ,  C12Q1/6897