公开(公告)号：US20140057907A1

公开(公告)日：2014-02-27

申请号：US14069222

申请日：2013-10-31

Applicant: PHARMACYCLICS, INC.

Inventor： Lee HONIGBERG ,  Erik Verner ,  Joseph J. Buggy ,  David Loury ,  Wei Chen

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/4985 ,  A61K31/519 ,  A61K45/06

Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.

公开(公告)号：US09181263B2

公开(公告)日：2015-11-10

申请号：US14605854

申请日：2015-01-26

Applicant: PHARMACYCLICS, INC.

Inventor： Lee Honigberg ,  Erik Verner ,  Joseph J. Buggy ,  David Loury ,  Wei Chen

IPC: C07D211/70 ,  C07D211/82 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K31/4985 ,  A61K31/519 ,  A61K45/06

Abstract: Described herein are irreversible kinase inhibitor compounds, exemplified by compounds of the following structure: methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of a disease such as cancer.

Abstract translation: 本文描述的是不可逆激酶抑制剂化合物，其例子包括以下结构的化合物：用于合成这种不可逆抑制剂的方法，以及使用这种不可逆抑制剂治疗诸如癌症的疾病的方法。

公开(公告)号：US08748468B2

公开(公告)日：2014-06-10

申请号：US13668167

申请日：2012-11-02

Applicant: Pharmacyclics, Inc.

Inventor： David Loury ,  Tarak Mody

IPC: A01N43/52 ,  A61K31/415 ,  A01N37/52 ,  A61K31/155 ,  A01N33/18 ,  A01N33/24 ,  A61K31/045 ,  A61K31/04

CPC classification number: A61K31/4184 ,  A61K31/4164 ,  A61K41/00 ,  A61K45/06 ,  C07D209/00 ,  C07D235/12 ,  C07D235/18 ,  A61K2300/00

Abstract: Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I:

Abstract translation: 本文公开了使用式I化合物治疗因子VIIa抑制剂的癌症和血栓栓塞障碍：

公开(公告)号：US20130158089A1

公开(公告)日：2013-06-20

申请号：US13668167

申请日：2012-11-02

Applicant: Pharmacyclics, Inc

Inventor： David Loury ,  Tarak Mody

IPC: A61K31/4184 ,  C07D235/12 ,  A61K45/06

CPC classification number: A61K31/4184 ,  A61K31/4164 ,  A61K41/00 ,  A61K45/06 ,  C07D209/00 ,  C07D235/12 ,  C07D235/18 ,  A61K2300/00

Abstract: Treatment of cancer and thromboembolic disorders using inhibitors of Factor VIIa are disclosed herein using a compound of Formula I:

Abstract translation: 本文公开了使用式I化合物治疗因子VIIa抑制剂的癌症和血栓栓塞障碍：