中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

12 records (took 0.048 seconds)

    MUTATIONS ASSOCIATED WITH RESISTANCE TO INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)
    6.
    发明申请
    MUTATIONS ASSOCIATED WITH RESISTANCE TO INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) 审中-公开
    与BRUTON的酪氨酸激酶（BTK）抑制剂相关的突变体

    公开(公告)号：US20150184249A1

    公开(公告)日：2015-07-02

    申请号：US14417097

    申请日：2013-07-23

    Applicant: PHARMACYCLICS, INC.

    Inventor： Betty Chang ,  Joseph J. Buggy ,  Susanne M. Steccerda

    IPC: C12Q1/68 ,  C12N9/12 ,  C12N9/16 ,  C07K14/00 ,  A61K31/506 ,  A61K31/505 ,  A61K31/519 ,  A61K45/06 ,  G01N33/50 ,  A61K31/52

    CPC classification number: C12Q1/6886 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  A61K45/06 ,  C07K14/00 ,  C12N9/12 ,  C12N9/16 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Y207/10002 ,  C12Y301/04011 ,  G01N33/5041

    Abstract: Described herein are mutations that confer resistance to treatment with a BTK inhibitor. Described herein are modified BTK polypeptides that exhibit decreased inhibition (i.e. are resistant) to a covalent and/or irreversible BTK inhibitor. Also described herein modifications of PLCy2 and CARD 11 polypeptides that confer resistance to treatment with a BTK inhibitor. Described herein are diagnostic methods for detecting the modified polypeptides and nucleic acids encoding the modified polypeptides and applications of the methods thereof. Described herein are compositions, combinations, and kits containing the modified polypeptides and methods of using the modified polypeptides. Also described herein are methods of using modified BTK polypeptides as screening agents for the identification and design of second-generation BTK inhibitors.

    Abstract translation: 本文描述了赋予对用BTK抑制剂治疗的抗性的突变。 本文描述的是对共价和/或不可逆的BTK抑制剂表现出降低的抑制（即抗性）的修饰的BTK多肽。 本文还描述了赋予对用BTK抑制剂治疗的抗性的PLCy2和CARD11多肽的修饰。 本文描述了用于检测修饰的多肽和编码经修饰的多肽的核酸的诊断方法及其方法的应用。 本文描述的是含有修饰多肽的组合物，组合和试剂盒，以及使用经修饰的多肽的方法。 本文还描述了使用修饰的BTK多肽作为用于鉴定和设计第二代BTK抑制剂的筛选剂的方法。

    USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)
    10.
    发明申请
    USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) 审中-公开
    使用BRUTON的酪氨酸激酶（BTK）抑制剂

    公开(公告)号：US20140303191A1

    公开(公告)日：2014-10-09

    申请号：US14353011

    申请日：2012-10-19

    Applicant: Pharmacyclics, Inc.

    Inventor： Joseph J. Buggy ,  Laurence Elias ,  Gwen Fyfe ,  Eric Hedrick ,  David J. Loury ,  Tarak D. Mody

    IPC: A61K31/519 ,  G01N33/574 ,  C12Q1/68 ,  A61K45/06

    Abstract: Methods are provided for treating a hematologic cancer comprising administering an anticancer agent to a subject identified as having an increased mobilization of a subpopulation of lymphocytes from a malignancy following administration of an irreversible Btk inhibitor. Methods also are provided for identification of subjects for treatment and the analysis of cells mobilized from a hematologic malignancy following administration of an irreversible Btk inhibitor.

    Abstract translation: 提供了用于治疗血液学癌症的方法，其包括对被鉴定为在施用不可逆的Btk抑制剂后从恶性肿瘤中增加的淋巴细胞亚群动员的受试者施用抗癌剂。 提供了用于鉴定治疗受试者的方法以及在施用不可逆Btk抑制剂之后从血液恶性肿瘤动员的细胞的分析。

Patent Agency Ranking