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1.发明申请CALCIUM FLUX AS A PHARMACOEFFICACY BIOMARKER FOR INHIBITORS OF HISTONE DEACETYLASE 审中-公开钙通道作为药物脱乙酰壳多糖抑制剂的药物生物标志物
公开(公告)号：WO2008128093A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/060098
申请日：2008-04-11
Applicant: PHARMACYCLICS, INC. , BALASUBRAMANIAN, Sriram , BUGGY, Joseph, J. , RAMOS, Jason , SIRISAWAD, Mint
Inventor： BALASUBRAMANIAN, Sriram , BUGGY, Joseph, J. , RAMOS, Jason , SIRISAWAD, Mint
IPC: A61K38/18
CPC classification number: G01N33/57438 , G01N33/6872 , G01N33/84 , G01N2800/52
Abstract: Described herein are methods for using calcium flux as a biomarker to select and predict patients likely to respond to an apoptotic agent as therapy. Further described herein is a method of using calcium flux as a clinical biomarker to determine whether a tumor is sensitive to an HDAC inhibitor.
Abstract translation: 本文描述了使用钙通量作为生物标志物来选择和预测可能对凋亡剂作出响应的患者作为治疗的方法。 本文进一步描述的是使用钙通量作为临床生物标志物来确定肿瘤是否对HDAC抑制剂敏感的方法。
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2.发明公开CALCIUM FLUX AS A PHARMACOEFFICACY BIOMARKER FOR INHIBITORS OF HISTONE DEACETYLASE 审中-公开钙通量作为一种药理活性生物标记物用于抑制剂DEACETYLASE
公开(公告)号：EP2144622A1
公开(公告)日：2010-01-20
申请号：EP08745659.6
申请日：2008-04-11
Applicant: PHARMACYCLICS, INC.
Inventor： BALASUBRAMANIAN, Sriram , BUGGY, Joseph, J. , RAMOS, Jason , SIRISAWAD, Mint
IPC: A61K38/18
CPC classification number: G01N33/57438 , G01N33/6872 , G01N33/84 , G01N2800/52
Abstract: Described herein are methods for using calcium flux as a biomarker to select and predict patients likely to respond to an apoptotic agent as therapy. Further described herein is a method of using calcium flux as a clinical biomarker to determine whether a tumor is sensitive to an HDAC inhibitor.
Abstract translation: 本文描述了使用钙通量作为生物标志物以选择和预测可能对作为治疗的凋亡剂作出反应的患者的方法。 本文进一步描述了使用钙通量作为临床生物标志物以确定肿瘤是否对HDAC抑制剂敏感的方法。
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