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公开(公告)号：WO2008054827A2
公开(公告)日：2008-05-08
申请号：PCT/US2007023306
申请日：2007-11-05
Applicant: PHARMACYCLICS INC , PAN ZHENGYING , LI SHYR JIANN , SCHEREENS HELEEN , HONIGBERG LEE , VERNER ERIK
Inventor： PAN ZHENGYING , LI SHYR JIANN , SCHEREENS HELEEN , HONIGBERG LEE , VERNER ERIK
IPC: G01N33/574
CPC classification number: C07D487/04 , G01N33/573 , G01N2333/9121 , G01N2500/00
Abstract: Described herein are probes for Bruton's tyrosine kinase (Btk). Such probes are used to characterize and develop Btk-selective inhibitors intended for therapeutic use.
Abstract translation: 本文描述了布鲁顿酪氨酸激酶（Btk）的探针。 这些探针用于表征和开发预期用于治疗用途的Btk选择性抑制剂。
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Patent Agency Ranking
公开(公告)号：CA2668286C
公开(公告)日：2014-09-16
申请号：CA2668286
申请日：2007-11-05
Applicant: PHARMACYCLICS INC
Inventor： PAN ZHENGYING , LI SHYR JIANN , SCHEREENS HELEEN , HONIGBERG LEE , VERNER ERIK
Abstract: Described herein are probes for Bruton's tyrosine kinase (Btk). Such probes are used to characterize and develop Btk-selective inhibitors intended for therapeutic use. The invention relates to a Btk activity probe comprising a Btk inhibitor moiety, a reporter moiety, and a linker moiety that links the inhibitor moiety to the reporter moiety. Specifically described are a Btk inhibitor moiety which covalently bonds to a cysteine residue of a Btk enzyme, a fluorophore and a linker moiety that links the inhibitor moiety to the fluorophore. In an embodiment, the Btk activity probe is: (see compound 3)
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公开(公告)号：CA2668286A1
公开(公告)日：2008-05-08
申请号：CA2668286
申请日：2007-11-05
Applicant: PHARMACYCLICS INC
Inventor： VERNER ERIK , LI SHYR JIANN , SCHEREENS HELEEN , PAN ZHENGYING , HONIGBERG LEE
IPC: C07D487/00
Abstract: Described herein are probes for Bruton's tyrosine kinase (Btk). Such prob es are used to characterize and develop Btk-selective inhibitors intended fo r therapeutic use.
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公开(公告)号：ES2403546T3
公开(公告)日：2013-05-20
申请号：ES07867362
申请日：2007-11-05
Applicant: PHARMACYCLICS INC
Inventor： PAN ZHENGYING , LI SHYR , SCHEREENS HELEEN , HONIGBERG LEE , VERNER ERIK
IPC: C07D487/00 , C07D487/04 , G01N33/573
Abstract: Sonda de actividad de la Btk que comprende un resto inhibidor de la Btk que se une covalentemente a un residuode cisteína de una enzima Btk, un fluoróforo y un resto conector que une el resto inhibidor al fluoróforo, en la que elresto inhibidor es el siguiente: **Fórmula**
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公开(公告)号：HK1132744A1
公开(公告)日：2010-03-05
申请号：HK10100318
申请日：2010-01-12
Applicant: PHARMACYCLICS INC
Inventor： PAN ZHENGYING , LI SHYR JIANN , SCHEREENS HELEEN , HONIGBERG LEE , VERNER ERIK
IPC: C07D20060101 , G01N20060101
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公开(公告)号：EP2089391A4
公开(公告)日：2010-03-17
申请号：EP07867362
申请日：2007-11-05
Applicant: PHARMACYCLICS INC
Inventor： PAN ZHENGYING , LI SHYR JIANN , SCHEREENS HELEEN , HONIGBERG LEE , VERNER ERIK
IPC: C07D487/00 , C07D487/04 , G01N33/573
CPC classification number: C07D487/04 , G01N33/573 , G01N2333/9121 , G01N2500/00
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