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    Inhibitor of bruton's tyrosine kinase
    3.
    发明专利
    Inhibitor of bruton's tyrosine kinase 有权
    BRUTON的酪氨酸激酶抑制剂

    公开(公告)号：JP2013060466A

    公开(公告)日：2013-04-04

    申请号：JP2012286719

    申请日：2012-12-28

    Applicant: Pharmacyclics Inc ,  ファーマサイクリクス,インコーポレイテッド

    Inventor： HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

    IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

    CPC classification number: A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24 ,  A61K2300/00

    Abstract: PROBLEM TO BE SOLVED: To provide therapeutic benefit to a patient having relevant diseases by inhibiting tyrosine kinase activity.SOLUTION: There are provided: compounds that form covalent bonds with Bruton's tyrosine kinase (Btk); irreversible inhibitors of Btk; methods for the preparation of the compounds; pharmaceutical compositions that include the compounds; and methods of using the Btk inhibitors, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    Abstract translation: 待解决的问题：通过抑制酪氨酸激酶活性为具有相关疾病的患者提供治疗益处。 提供：与Bruton酪氨酸激酶（Btk）形成共价键的化合物; Btk不可逆抑制剂; 化合物的制备方法; 包括化合物的药物组合物; 以及使用Btk抑制剂单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症的方法。 版权所有（C）2013，JPO＆INPIT

    INHIBITORS OF BRUTON'S TYROSINE KINASE
    4.
    发明申请
    INHIBITORS OF BRUTON'S TYROSINE KINASE 审中-公开
    酪氨酸激酶抑制剂

    公开(公告)号：WO2008039218A3

    公开(公告)日：2008-05-29

    申请号：PCT/US2006049626

    申请日：2006-12-28

    Applicant: PHARMACYCLICS INC ,  HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

    Inventor： HONIGBERG LEE ,  VERNER ERIK ,  PAN ZHENGYING

    IPC: A01N43/90 ,  A61K31/519

    CPC classification number: A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24 ,  A61K2300/00

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    Abstract translation: 本文公开了与布鲁顿酪氨酸激酶（Btk）形成共价键的化合物。 还描述了Btk的不可逆抑制剂。 公开了制备这些化合物的方法。 还公开了包含该化合物的药物组合物。 单独或与其他治疗剂组合使用Btk抑制剂的方法用于治疗自身免疫疾病或病症，异质性免疫疾病或病症，癌症（包括淋巴瘤）和炎性疾病或病症。

    INHIBITORS OF BRUTONS TYROSINE KINASE
    9.
    发明专利
    INHIBITORS OF BRUTONS TYROSINE KINASE 未知

    公开(公告)号：HK1178144A1

    公开(公告)日：2013-09-06

    申请号：HK13104973

    申请日：2013-04-24

    Applicant: PHARMACYCLICS INC

    Inventor： HONIGBERG LEE ,  VERNER ERLK ,  PAN ZHENGYING

    IPC: C07D20060101

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    INHIBITORS OF BRUTON'S TYROSINE KINASE
    10.
    发明专利
    INHIBITORS OF BRUTON'S TYROSINE KINASE 未知

    公开(公告)号：ZA201207075B

    公开(公告)日：2013-06-26

    申请号：ZA201207075

    申请日：2012-09-20

    Applicant: PHARMACYCLICS INC

    Inventor： HONIGBERG LEE ,  PAN ZHENGYING ,  VERNER ERIK

    IPC: A61K20060101 ,  A01N20060101 ,  A61P20060101

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

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