公开(公告)号：DE59911263D1

公开(公告)日：2005-01-20

申请号：DE59911263

申请日：1999-07-21

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： PICHT FRIEDERIKE ,  CZARNOJAN WOLFRAM ,  FELDMANN CLAUS ,  JUNGK HANS-OTTO ,  MERIKHI JACQUELINE ,  VAN DE BELT ROEL ,  VAN DONGEN ANNE MARIE ,  VAN DER HEIJDEN ALEXANDRA

IPC: G09F9/30 ,  C09K11/02 ,  C09K11/08 ,  C09K11/55 ,  C09K11/84 ,  G09F13/20 ,  H01J29/18 ,  H01J29/20 ,  H01J29/22

公开(公告)号：DE60229743D1

公开(公告)日：2008-12-18

申请号：DE60229743

申请日：2002-05-30

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： OSKAM KOERT ,  MEIJERINK ANDRIES ,  WEGH RENE T ,  FELDMANN CLAUS ,  WIECHERT DETLEF U ,  JUESTEL THOMAS ,  RONDA CORNELIS R

IPC: C09K11/85 ,  H01J61/44 ,  C09K11/61 ,  C09K11/77

Abstract: A gas discharge lamp has a gas discharge vessel filled with a gas filling suitable for a gas discharge which emits VUV radiation, with a phosphor coating containing a downconversion phosphor. The downconversion phosphor has, in a host lattice, a pair of activators of a first lanthanoid ion and a second lanthanoid ion; a sensitizer selected from the group formed by the thallium(I) ion, lead(II) ion and bismuth(III) ion; and samarium(II) ion co-activator.

公开(公告)号：DE50002885D1

公开(公告)日：2003-08-21

申请号：DE50002885

申请日：2000-01-07

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： FELDMANN CLAUS ,  OPITZ JOACHIM

IPC: H01J1/63 ,  C01B21/084 ,  C09K11/02 ,  C09K11/08 ,  G09F9/00 ,  H01J29/18 ,  H01J29/20

公开(公告)号：WO2005094902A3

公开(公告)日：2006-05-26

申请号：PCT/IB2005051021

申请日：2005-03-24

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  FELDMANN CLAUS

Inventor： FELDMANN CLAUS

IPC: A61K49/00 ,  C09K11/57 ,  C09K11/74 ,  C09K11/77

CPC classification number: A61K49/0013 ,  A61K49/0063 ,  A61K49/0067 ,  A61K49/0093 ,  C09K11/57 ,  C09K11/74 ,  C09K11/7721 ,  C09K11/7774

Abstract: A contrast agent for optical imaging comprising particles (1) consisting of at least a core (2), wherein the core comprises luminescent substances absorbing and emitting electromagnetic radiation at different wavelengths.

Abstract translation: 一种用于光学成像的造影剂，其包括由至少核心（2）组成的颗粒（1），其中所述核心包括吸收和发射不同波长的电磁辐射的发光物质。

公开(公告)号：WO2005058360A3

公开(公告)日：2006-05-26

申请号：PCT/IB2004052725

申请日：2004-12-09

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  JUESTEL THOMAS ,  FELDMANN CLAUS

Inventor： JUESTEL THOMAS ,  FELDMANN CLAUS

IPC: A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61P35/00

CPC classification number: A61K49/0428 ,  A61K41/00 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

Abstract: The invention relates to UV emitting nanoparticles for radiation therapy purposes. If the nanoparticles are brought indirectly or directly to the diseased tissue, excitation with high energy radiation leads to VUV or UV-C emission. This UV radiation is absorbed by the surrounding organic matrix, resulting in decomposition of the material. The nanoparticles can also be modified by attaching antibodies to the particles by chemical linking or coating. Preferably these antibodies bind specifically to the cell membrane of cancer cells leading to a localised destruction of diseased tissue with a high efficacy and a lower level of destruction of surrounding healthy tissue. Endoscopic detection of the UV emission can be used as a medical imaging technique to locate and study diseased tissue.

Abstract translation: 本发明涉及用于放射治疗目的的UV发射纳米颗粒。 如果纳米颗粒被间接地或直接地带到患病组织，则用高能量辐射的激发导致VUV或UV-C发射。 这种紫外线辐射被周围的有机基质吸收，导致材料分解。 还可以通过化学连接或涂覆将抗体附着于颗粒来修饰纳米颗粒。 优选地，这些抗体特异性结合癌细胞的细胞膜，导致病变组织的局部破坏，具有高效力和较低水平的周围健康组织的破坏。 紫外线发射的内窥镜检测可用作医学成像技术来定位和研究患病组织。