公开(公告)号：DE602004026460D1

公开(公告)日：2010-05-20

申请号：DE602004026460

申请日：2004-10-04

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： NIELSEN TIM ,  KOEHLER THOMAS

IPC: G06T11/00

Abstract: Iterative algorithms, which may be used for image reconstruction, include alternating projections and backprojections usually have a slow convergence, due to correlations between simultaneously processed data. Consequently, a low image quality results. A filtering step is introduced before backprojection, allowing parallel processing without the loss of convergence speed or image quality. Advantageously, this allows several projections/backprojections to be performed simultaneously.

公开(公告)号：DE602004027835D1

公开(公告)日：2010-08-05

申请号：DE602004027835

申请日：2004-12-06

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： NIELSEN TIM ,  PROKSA ROLAND

IPC: G06T11/00

公开(公告)号：DE602006019292D1

公开(公告)日：2011-02-10

申请号：DE602006019292

申请日：2006-09-01

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： GRASS MICHAEL ,  ZIEGLER ANDY ,  NIELSEN TIM

IPC: A61B6/03 ,  G06T5/00 ,  G06T5/50 ,  G06T11/00

公开(公告)号：DE602007008571D1

公开(公告)日：2010-09-30

申请号：DE602007008571

申请日：2007-06-25

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： NIELSEN TIM ,  KOEHLER THOMAS

IPC: A61B5/00

公开(公告)号：WO2009060383A3

公开(公告)日：2009-07-30

申请号：PCT/IB2008054583

申请日：2008-11-04

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  KOEHLER THOMAS ,  NIELSEN TIM ,  BAKKER LEVINUS P

Inventor： KOEHLER THOMAS ,  NIELSEN TIM ,  BAKKER LEVINUS P

IPC: G01N21/47 ,  A61B5/00 ,  A61B6/00

CPC classification number: G01N21/4795 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2560/0233

Abstract: A method for calibrating a device for imaging the interior of turbid media is provided. The device for imaging the interior of turbid media uses a fluorescent contrast agent emitting fluorescence light and comprises a receptacle (2) for receiving a turbid medium (1 ) during examination; at least one light source optically connected to the receptacle (2) for irradiating the interior of the receptacle with light of a predetermined wavelength (?L); at least one detector optically connected to the receptacle (2) for detecting light emanating from the interior of the receptacle; and at least one filter introducible in the detection light path from the receptacle (2) to the at least one detector. The method for calibrating comprises the steps: - performing a first reference measurement with the receptacle (2) filled with an optically matching medium (4); - performing a second reference measurement with the receptacle (2) filled with a mixture of the optically matching medium and a fluorescent contrast agent; - calibrating the device based on the results of the first reference measurement and the second reference measurement.

Abstract translation: 提供了一种用于校准用于对浑浊介质内部进行成像的装置的方法。 用于对混浊介质内部进行成像的装置使用发射荧光的荧光对比剂，并且包括用于在检查期间接收混浊介质（1）的容器（2） 至少一个光源，其光学连接到所述插座（2），用于用预定波长（λL）的光照射所述插座的内部; 至少一个检测器，其光学连接到所述容器（2），用于检测从所述容器的内部发出的光; 以及至少一个滤光器，其引导到从所述插座（2）到所述至少一个检测器的检测光路中。 用于校准的方法包括以下步骤： - 用填充有光学匹配介质（4）的容器（2）执行第一参考测量; - 用所述光学匹配介质和荧光对比剂的混合物填充的所述容器（2）执行第二参考测量; - 根据第一个参考测量结果和第二个参考测量结果校准设备。

公开(公告)号：WO2006064392A3

公开(公告)日：2007-12-21

申请号：PCT/IB2005054042

申请日：2005-12-05

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  NIELSEN TIM ,  GLEICH BERNHARD ,  WEIZENECKER JUERGEN

Inventor： NIELSEN TIM ,  GLEICH BERNHARD ,  WEIZENECKER JUERGEN

IPC: G06T11/00

CPC classification number: A61B5/05 ,  A61B5/0515 ,  A61B5/7257

Abstract: The invention relates to a method of determining a spatial distribution of magnetic particles in an examination area, in which a magnetic field is generated which has a first part-region having a relatively low magnetic field strength and a second part-region having a relatively high magnetic field strength. The position of the two part-regions is changed, as a result of which the magnetization in the examination area changes, and real measured values which depend on the change in magnetization are recorded. A dependence distribution which depends on a spatial distribution of magnetic particles is then determined such that a sum which comprises as summands a) the difference of the real measured values from fictitious measured values which are determined by applying a transfer function to the dependence distribution, and b) the product of a regularization parameter and of a regularization value which is determined by applying the regularization functional to the dependence distribution, is minimized. Finally, the spatial distribution of magnetic particles is determined by means of the determined dependence distribution.

Abstract translation: 本发明涉及一种确定检测区域中的磁性颗粒的空间分布的方法，其中产生磁场，其具有磁场强度较低的第一部分区域和具有较高磁场强度的第二部分区域 磁场强度。 两部分区域的位置发生变化，其结果是检查区域的磁化改变，并且记录取决于磁化变化的实测值。 然后确定依赖于磁性颗粒的空间分布的依赖性分布，使得包括作为求和的和a）通过将依赖分布应用传递函数确定的实际测量值与虚构测量值的差异，以及 b）将正则化参数和通过对依赖分布应用正则化函数确定的正则化值的乘积最小化。 最后，通过确定的依赖分布来确定磁性颗粒的空间分布。

公开(公告)号：WO2007031911A3

公开(公告)日：2007-06-07

申请号：PCT/IB2006053144

申请日：2006-09-07

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  NIELSEN TIM ,  KOEHLER THOMAS

Inventor： NIELSEN TIM ,  KOEHLER THOMAS

IPC: A61B5/00

CPC classification number: A61B5/0073 ,  A61B5/14551 ,  A61B5/1495

Abstract: In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.

Abstract translation: 在光学层析成像中，图像重构可能需要校准数据。 根据本发明的示例性实施例，感兴趣的对象被用于校准，其中在感兴趣对象的高度充氧阶段期间获取图像数据，并且其中在对象的低氧合期期间获取校准数据 出于兴趣。 这可以提供改进的校准，导致改善的图像质量。

公开(公告)号：WO2007031899A3

公开(公告)日：2008-04-17

申请号：PCT/IB2006053055

申请日：2006-09-01

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  GRASS MICHAEL ,  ZIEGLER ANDY ,  NIELSEN TIM

Inventor： GRASS MICHAEL ,  ZIEGLER ANDY ,  NIELSEN TIM

IPC: A61B6/03 ,  G06T5/00 ,  G06T5/50 ,  G06T11/00

CPC classification number: A61B6/032 ,  A61B6/027 ,  A61B6/541 ,  G06T11/006 ,  G06T2211/412 ,  G06T2211/424

Abstract: The increasing cone angle of current high-end and future CT systems leads to a decrease in image quality if approximate cone-beam reconstruction methods are used. According to an exemplary embodiment of the present invention, an iterative four-dimensional cardiac CT reconstruction is provided, in which phase volumes are selected from the four-dimensional data set, each having the same spatial volume at different phase points. Corresponding voxels inside these phase volumes are then forward projected onto the same projection. After calculation of a different projection, these voxels are updated. This may provide for an efficient implementation of an iterative four-dimensional cardiac cone-beam CT reconstruction.

Abstract translation: 目前的高端和未来CT系统的锥角越来越大，如果使用近似锥束重建方法，则会导致图像质量下降。 根据本发明的示例性实施例，提供了一种迭代的四维心脏CT重建，其中从四维数据集中选择相位体积，每个四维数据集在不同相位处具有相同的空间体积。 然后将这些相位体积内的相应体素向前投影到相同的投影上。 在计算了不同的投影之后，这些体素被更新。 这可以提供迭代四维心脏锥束CT重建的有效实施。

公开(公告)号：WO2006000997A3

公开(公告)日：2007-04-26

申请号：PCT/IB2005052090

申请日：2005-06-24

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  NIELSEN TIM ,  ZIEGLER ANDY ,  KOEHLER THOMAS ,  PROKSA ROLAND

Inventor： NIELSEN TIM ,  ZIEGLER ANDY ,  KOEHLER THOMAS ,  PROKSA ROLAND

IPC: G06T11/00

CPC classification number: G06T11/006 ,  A61B6/027 ,  G06T2211/421 ,  Y10S378/901

Abstract: The invention relates to an imaging method, especially a computerized tomography method, with which an object is penetrated by rays from different directions and measured values, which depend upon the intensity of the rays after penetrating the object, are acquired by a detector unit. From these measured values, an object image is reconstructed by means of back projection of measured-value-dependent back projection values. Therein, the object image is divided into overlapping, quasi-spherically symmetric image segments, each being defined by an image value and a quasi-spherically symmetric base function. Furthermore, during the back projection, the back projection values are added in proportions to the image values, wherein the proportion of a back projection value, which is added during the back projection to an image value, is dependent on a proportionality factor, which is equal to the average value of the line integrals of the base function belonging to the respective image value along those rays that have generated the measured value, on which the respective back projection value is dependent.

Abstract translation: 本发明涉及一种成像方法，特别是计算机断层摄影方法，其中物体被来自不同方向的光线穿透，并且测量值取决于穿透物体之后的光线的强度，由检测器单元获取。 从这些测量值，通过背投影测量值依赖的反投影值重建对象图像。 其中，对象图像被划分为重叠的准球形对称图像片段，每个片段由图像值和准球形对称的基本功能定义。 此外，在背投影期间，反投影值以与图像值成比例的方式相加，其中在后投影中添加的反投影值与图像值的比例取决于比例因子，即比例因子 等于属于相应图像值的基本功能的线积分的平均值，沿着相应的背投影值依赖于已经产生测量值的那些射线。

公开(公告)号：WO2006067692A3

公开(公告)日：2006-09-08

申请号：PCT/IB2005054248

申请日：2005-12-14

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  GLEICH BERNHARD ,  WEIZENECKER JUERGEN ,  NIELSEN TIM

Inventor： GLEICH BERNHARD ,  WEIZENECKER JUERGEN ,  NIELSEN TIM

IPC: A61B5/05

CPC classification number: A61B5/05 ,  A61B5/0515

Abstract: The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non- saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument.

Abstract translation: 本发明涉及用于确定检查区域中的磁性颗粒的空间分布的布置和方法。 磁场装置用于产生具有低场强的至少一个区域的空间不均匀梯度磁场，其中，粒子的磁化处于非饱和状态，而它们处于饱和状态 剩余区域。 通过使用改变装置在检查区域内以低场强移动区域，引起磁性粒子的磁化变化，其可以由检测装置从外部检测到，并且包含关于磁性粒子的空间分布的信息 在考试区域。 磁场装置或改变装置或检测装置或这些装置的组合至少部分地布置在医疗器械上。