公开(公告)号：DE602005004410T2

公开(公告)日：2009-01-08

申请号：DE602005004410

申请日：2005-06-29

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： SPIES LOTHAR

IPC: G06T5/00 ,  G06T11/00

Abstract: The invention relates to an imaging system for imaging an object (4), said imaging system comprising a detection unit (3) for consecutively acquiring projection data sets (Pi) of the object (4), said detection unit (3) having a temporal response function that is characterized by at least a time constant (τ), a rotation unit that, while the projection data sets (Pi) are being acquired, moves the detection unit (3) around the object (4) with an essentially constant angular velocity (ω), a reconstruction unit (9) for computing an image data set (13) of the object (4) from the projection data sets (Pi), and a filter unit (10) that, in an active state, applies a filter (f) on the image data set (13) to compute a correction, which filter acts as a derivative on the perturbed image, essentially in a direction corresponding to the direction of the angular velocity, is essentially proportional to the time constant (τ) and is essentially proportional to the angular velocity (ω), said filter unit (10) being arranged to subtract the correction from the image data set (13).

公开(公告)号：DE602006017842D1

公开(公告)日：2010-12-09

申请号：DE602006017842

申请日：2006-05-01

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： SPIES LOTHAR ,  BAL MATTHIEU ,  MCNUTT TODD

IPC: A61N5/10

公开(公告)号：DE602004017129D1

公开(公告)日：2008-11-27

申请号：DE602004017129

申请日：2004-01-19

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： BOTTERWECK HENRIK ,  SPIES LOTHAR

IPC: A61N5/10 ,  A61B6/03

Abstract: In order to reduce an x-ray dose applied to a patient, it is necessary to know the dose absorbed by the patient. According to the present invention, there is provided a method of determining a local patient dose applied to a patient where after the reconstruction of the scan data into a diagnostic image, the scan data are backprojected into the patient volume, using the attenuation information of the diagnostic image to form a spatially varying photon fluence map. In parallel, the diagnostic image is segmented into anatomical structures to which dose-weighting factors are assigned. The locally absorbed dose is then calculated on the basis of the fluence map and the corresponding dose weights.

公开(公告)号：DE602005004410D1

公开(公告)日：2008-03-06

申请号：DE602005004410

申请日：2005-06-29

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： SPIES LOTHAR

IPC: G06T5/00 ,  G06T11/00

Abstract: The invention relates to an imaging system for imaging an object (4), said imaging system comprising a detection unit (3) for consecutively acquiring projection data sets (Pi) of the object (4), said detection unit (3) having a temporal response function that is characterized by at least a time constant (τ), a rotation unit that, while the projection data sets (Pi) are being acquired, moves the detection unit (3) around the object (4) with an essentially constant angular velocity (ω), a reconstruction unit (9) for computing an image data set (13) of the object (4) from the projection data sets (Pi), and a filter unit (10) that, in an active state, applies a filter (f) on the image data set (13) to compute a correction, which filter acts as a derivative on the perturbed image, essentially in a direction corresponding to the direction of the angular velocity, is essentially proportional to the time constant (τ) and is essentially proportional to the angular velocity (ω), said filter unit (10) being arranged to subtract the correction from the image data set (13).

公开(公告)号：WO2005116647A2

公开(公告)日：2005-12-08

申请号：PCT/IB2005051665

申请日：2005-05-23

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

Inventor： PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

IPC: G01N33/50 ,  G06F19/00

CPC classification number: G06T7/20 ,  G06F19/321 ,  G06T2207/10072 ,  G06T2207/30004 ,  G16H50/50

Abstract: The invention relates to the estimation of kinetic parameters for a target region (210) utilizing information from a normal (unperturbed) reference region (200). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure features two alternatives: (A) Extraction of the plasma input in the reference region (200) and its unperturbed kinetic parameters, hereafter utilization of the plasma input and the kinetic parameters of the reference region as initial parameters for the analysis of the target region (210). (B) The system of kinetic equations describing the kinetics of the imaging agent in the target and reference regions is solved for the input function (amount of free imaging agent in the plasma or the total imaging agent SB(t) contained in plasma, blood elements and metabolites) considered to be the same for both regions.

Abstract translation: 本发明涉及利用来自正常（未扰动）参考区域（200）的信息估计目标区域（210）的动力学参数。 提出的区室模型为血液，参考和靶组织建立代谢途径。 提出的分析程序具有两个选择：（A）参考区域（200）中的等离子体输入的提取及其未扰动的动力学参数，以下将等离子体输入的利用和参考区域的动力学参数用作分析的初始参数 目标区域（210）。 （B）解决了描述目标和参考区域中成像剂的动力学的动力学方程的系统，用于输入功能（等离子体中的游离显像剂的量或血浆中的总成像剂SB（t），血液 元素和代谢物）被认为是相同的两个地区。

公开(公告)号：WO2005109343A3

公开(公告)日：2006-10-12

申请号：PCT/IB2005051446

申请日：2005-05-03

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  PAULUS TIMO ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR

Inventor： PAULUS TIMO ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR

IPC: G06T7/00 ,  G06F19/00

CPC classification number: G06T7/0012 ,  G06F19/321 ,  G06T2200/04 ,  G06T2207/10104 ,  G06T2207/20092 ,  G06T2207/30004

Abstract: The invention relates to a data processing system (1) for the evaluation of image data, particularly of PET-images (I), that represent the time varying concentration of a tracer substance like F-MISO in an object (20). The data processing system (1) comprises a library module (48) with analytical solutions (C j (t)) for several compartment models. Preferably the library also contains the analytical gradients with respect to the parameters of interest. From the library an appropriate solution for each study can be chosen by a user. The use of analytical functions together with the information about the error (s A ( t )) of the input data (either via noise models 43 or via a simulation 44) allows to extract all parameters mandatory to fully understand the kinetics of complex models (more than one tissue compartment) on a per-voxel basis in a robust way in real-time.

Abstract translation: 本发明涉及一种用于评价特定于PET图像（I）的图像数据的数据处理系统（1），其表示物体（20）中的示踪物质如F-MISO的时变浓度。 数据处理系统（1）包括具有用于几个隔室模型的分析解决方案（C（j））的库模块（48）。 优选地，库还包含关于感兴趣的参数的分析梯度。 从图书馆，每个研究的适当解决方案可由用户选择。 使用分析功能以及关于输入数据的错误（通过噪声模型43或经由模拟44）的错误的信息允许（例如， 提取所有必要的参数，以实时的方式，以健壮的方式充分了解复杂模型（多于一个组织室）的动力学。

公开(公告)号：WO2007034378A3

公开(公告)日：2008-11-20

申请号：PCT/IB2006053265

申请日：2006-09-13

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  PHILIPS CORP ,  FISCHER ALEXANDER ,  SPIES LOTHAR

Inventor： FISCHER ALEXANDER ,  SPIES LOTHAR

IPC: G06T7/00

CPC classification number: G06T7/0012 ,  A61B5/055 ,  G01R33/5608 ,  G06K9/3233 ,  G06K2209/05 ,  G06T7/11 ,  G06T2207/30004

Abstract: The present invention provides a system, apparatus, and method that are based on a priori knowledge of the shape of the input function for defining an input region-if- interest (ROI) in pharmacokinetic modeling. Kinetic parameter estimation requires knowledge of tracer input activity and the present invention provides an automatic way to define an ROI for estimation of an input function that takes into account a priori knowledge of the shape of the input function based on an administered dose. As a result of the application of the present invention to existing imaging analysis systems, there is a reduction in the amount of manual interaction needed and operator dependence is thereby reduced in the evaluation of dynamic procedures.

Abstract translation: 本发明提供了一种系统，装置和方法，其基于用于在药代动力学建模中定义输入区域 - 如果感兴趣（ROI）的输入函数的形状的先验知识。 动力学参数估计需要了解示踪剂输入活动的知识，并且本发明提供了一种自动方式来定义用于估计输入功能的ROI，其基于施用的剂量考虑到输入功能的形状的先验知识。 作为将本发明应用于现有成像分析系统的结果，在动态过程的评估中减少了所需的手动交互量，从而降低了操作者依赖性。

公开(公告)号：WO2007088492A2

公开(公告)日：2007-08-09

申请号：PCT/IB2007050204

申请日：2007-01-22

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  SPIES LOTHAR ,  HUMMEL HELGA ,  RIBBING CAROLINA ,  HOFFMANN RALF ,  BACHMANN PETER KLAUS

Inventor： SPIES LOTHAR ,  HUMMEL HELGA ,  RIBBING CAROLINA ,  HOFFMANN RALF ,  BACHMANN PETER KLAUS

IPC: A61N5/10

CPC classification number: A61N5/1031

Abstract: An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in- vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer.

Abstract translation: 建议采用改进的放射治疗计划程序。 该方法包括以下步骤：通过体外测试来指定和确定细胞退化的绝对等级，由此检测和量化指示特异性细胞退化的标志物，建立具有相似等级相对细胞的区域的基于生物学的分割 退化并将绝对等级的细胞退化应用于基于生物学的分割数据，从而建立改进的放射治疗计划程序。 此外，本发明提出了一种改进的放射治疗计划程序及其在癌症诊断和/或治疗管理程序中的应用的系统。

公开(公告)号：WO2007107946A3

公开(公告)日：2009-03-05

申请号：PCT/IB2007050942

申请日：2007-03-19

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  SPIES LOTHAR ,  NARAYANAN MANOJ ,  BAKKER BART J

Inventor： SPIES LOTHAR ,  NARAYANAN MANOJ ,  BAKKER BART J

IPC: A61B5/0275

CPC classification number: A61B5/02755 ,  G06T7/20 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/30004 ,  G16H50/50

Abstract: A method within dynamic molecular imaging comprising dynamically estimating a first parameter (ß(x)) and a second parameter (k(x)) of an activity function describing the bio distribution of an administered tracer, is disclosed. More specifically, the method comprises specifying a first target variance (sß,T(x)) and a second target variance (sß,T(x)) of the first parameter (ß(x)) and the second parameter (k(x)) of the activity function, respectively; initiating an image acquisition; reconstructing the first parameter (ß(x)) and the second parameter (k(x) ); reconstructing a first associated variance (sß(x)) and a second associated variance (sk(x)) of the first parameter (ß(x) ) and the second parameter (k(x)), respectively; and repeating the image acquisition and the reconstructing until the first associated variance (sß(x)) and the second associated variance (sk(x)) are equal to or less than the first target variance (sß,T (x)) and the second target variance (sß,T (x)), respectively, sß(x)=sß,T(x) and sk(x)=sß,T (x). The method enables patient- specific adaptive protocols within molecular imaging.

Abstract translation: 公开了动态分子成像中的方法，其包括动态估计描述所施用示踪物的生物分布的活动函数的第一参数（ß（x））和第二参数（k（x））。 更具体地说，该方法包括指定第一参数（β（x））和第二参数（k（x））的第一目标方差（sβ，T（x））和第二目标方差（sβ，T（x） ））的活动函数; 启动图像采集; 重建第一参数（ß（x））和第二参数（k（x））; 分别重建第一参数（β（x））和第二参数（k（x））的第一相关方差（sβ（x））和第二相关方差（sk（x））; 并且重复图像获取和重建直到第一相关方差（sβ（x））和第二相关方差（sk（x））等于或小于第一目标方差（sβ，T（x）），并且 第二个目标方差（sß，T（x））分别为s（x）=sß，T（x）和sk（x）=sß，T（x）。 该方法使分子成像中的患者特异性自适应方案成为可能。

公开(公告)号：WO2005116902A3

公开(公告)日：2006-08-17

申请号：PCT/IB2005051645

申请日：2005-05-20

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

Inventor： PELIGRAD DRAGOS-NICOLAE ,  SPIES LOTHAR ,  PAULUS TIMO

IPC: G06F19/00

CPC classification number: G06F19/321 ,  G16H10/40

Abstract: The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (C p ) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (S INJ (t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

Abstract translation: 本发明涉及一般的复合隔室模型和隔室分析程序，其非侵入性地提取血浆（301）中的成像剂在代谢物（304,504）中的浓度（C） 在来自在参考组织区域（200）内测量的时间信号曲线的血液元件（303）（如红细胞，血小板，血浆蛋白等）中。 这可以通过部署作为输入的注射功能（SUB）作为输入，其作为时间的函数对施用给患者的成像剂的量进行建模。 本发明允许向医生介绍等离子体输入功能，而不需要侵入性地抽取血液样本。