公开(公告)号：AU703903B2

公开(公告)日：1999-04-01

申请号：AU7259896

申请日：1996-10-04

Applicant: PHOTOELECTRON CORP

Inventor： SLISKI ALAN P ,  DALTERIO MICHAEL ,  SMITH DONALD O

IPC: G01T7/00 ,  A61N5/10 ,  G01T1/169 ,  G01D18/00

Abstract: A phantom apparatus for measuring the radiation dose distribution produced by a brachytherapy device used to treat a localized area with radiation. The brachytherapy device includes an insertable probe capable of producing predefined radiation dose geometries about a predefined point. The phantom apparatus includes a tank containing a medium having a radiological equivalent characteristic of the localized area to be treated. The phantom apparatus also includes a radiation sensor for measuring the radiation dose and a positioning system for moving the probe with respect to the radiation sensor. The radiation sensor is also coupled to a positioning system to orient the sensor for optimal dose measurements. The phantom apparatus includes a control system that coordinates the movements of the probe and the radiation sensor to avoid a collision. The control system moves the probe along a predefined path around radiation sensor and records the dose at predefined points along the path. In order to reduce the settling time of the sensor, the path is selected to coincide with the isodose contours of the radiation dose distribution of the probe.

公开(公告)号：EP0740847A4

公开(公告)日：1998-02-04

申请号：EP95908611

申请日：1995-01-19

Applicant: PHOTOELECTRON CORP

Inventor： DINSMORE MARK T ,  HARTE KENNETH J ,  SLISKI ALAN P ,  SMITH DONALD O ,  OETTINGER PETER E

IPC: A61B19/00 ,  A61N5/10 ,  H01B11/22 ,  H01J35/00 ,  H01J35/06 ,  H01J35/08 ,  H01J35/14 ,  H01J35/30 ,  H01J35/32 ,  H05G1/00 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

CPC classification number: A61N5/1001 ,  A61B90/11 ,  A61B2090/101 ,  A61N2005/1005 ,  H01J35/065 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H01J2201/342 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

Abstract: This invention is directed to an x-ray source comprising a housing (12), a power supply (12A), an elongated tubular probe (14), a target assembly (26), and a beam steering assembly (29). The housing encloses an electron beam source (22), and has elements for generating an electron beam along a beam path. The power supply (12A) is programmable to control the voltage, current and timing of an electron beam. The elongated tubular probe (14) extends along a central axis from the housing (12) about the beam path. The target assembly (26) extends along the central axis and is adapted for coupling to end of the probe (14) distal from the housing (12). The target assembly (26) includes target element (26A) positioned along the beam path, wherein the target element (26A) is adapted to emit x-rays in a predetermined spectral range in response to incident electrons. The beam steering assembly (29) includes a deflection element (30), a feedback network (31) and a deflection controller (144). The deflection element (30) deflects the beam from a nominal axis to a selected surface region on the target element (26) in response to a deflection control signal. The feedback network (31) includes deflection sensing elements for sensing the deflection of the beam and elements for generating a feedback signal representative thereof.

公开(公告)号：EP0770258A4

公开(公告)日：1997-08-13

申请号：EP95925598

申请日：1995-07-11

Applicant: PHOTOELECTRON CORP

Inventor： SMITH DONALD O ,  SLISKI ALAN P ,  HARTE KENNETH J

IPC: G21K5/02 ,  A61B1/00 ,  A61N5/10 ,  G01N23/083 ,  G21K5/00 ,  G21K5/04 ,  G21K5/10 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

CPC classification number: A61N5/1001 ,  A61N2005/1005 ,  G21K5/04 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H01J2201/342 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

Abstract: The present invention is directed to an x-ray source (10) for irradiating a surface defining a body cavity. The source comprises a housing (12), an elongated tubular probe (14), a target assembly (26), and an inflatable balloon (410). The housing (12) encloses an electron beam source (22) and includes elements (23) for generating an electron beam along a beam path. The tubular probe (14) extends along a central axis from the housing (12) about the beam path. The target assembly (26) extends along the central axis and is coupled to the probe distal end. The target assembly (26) includes a target element (26A, 26B) adapted to emit x-rays in response to electrons incident thereon. The probe tip assembly and associated control electronics include elements for positioning the target element in the beam path, and is substantially x-ray transparent. The balloon (410) affixed to the distal end is inflatable so as to be inflated to stretch the cavity to a shape, thus allowing a uniform delivery of dose of radiation to the surface defining a body cavity.

公开(公告)号：EP0855015A4

公开(公告)日：1999-11-03

申请号：EP96934099

申请日：1996-10-04

Applicant: PHOTOELECTRON CORP

Inventor： SLISKI ALAN P ,  DALTERIO MICHAEL ,  SMITH DONALD O

IPC: G01T7/00 ,  A61N5/10 ,  G01T1/169 ,  G01D18/00

CPC classification number: G01T1/169 ,  A61N5/1048

Abstract: This invention is a phantom apparatus (10) for measuring the radiation dose distribution produced by a brachy-therapy device used to treat a localized area with radiation. The brachy-therapy device includes an insertable probe (24) capable of producing predefined radiation dose geometries about a predefined point. The phantom apparatus (10) includes a tank (12) containing a medium having a radiological equivalent characteristic of the localized area to be treated. The phantom apparatus (10) also includes a radiation sensor (32) for measuring the radiation dose and a positioning system for moving the probe (24) with respect to the radiation sensor (32). The radiation sensor (32) is also coupled to a positioning system (50) to orient the sensor (32) for optimal dose measurements. The phantom apparatus (10) includes a control system (160) that coordinates the movements of the probe (24) and the radiation sensor (32) to avoid a collision. The control system (160) moves the probe (24) along a predefined path around radiation sensor (32) and records the dose at predefined points along the path. In order to reduce the settling time of the sensor (32), the path is selected to coincide with the isodose contours of the radiation dose distribution of the probe (24).

公开(公告)号：AU5299393A

公开(公告)日：1994-04-26

申请号：AU5299393

申请日：1993-10-01

Applicant: PHOTOELECTRON CORP

Inventor： SMITH DONALD O ,  SLISKI ALAN P ,  HARTE KENNETH J ,  BIGGS PETER J ,  BEATTY JOHN F

IPC: A61N5/10 ,  H01J35/00 ,  H01J35/22 ,  H01J35/32 ,  H05G1/00 ,  H05G1/06 ,  H05G1/10 ,  H05G1/20 ,  H05G1/32 ,  H05G1/34 ,  H01J35/14

公开(公告)号：AT207651T

公开(公告)日：2001-11-15

申请号：AT95925598

申请日：1995-07-11

Applicant: PHOTOELECTRON CORP

Inventor： SMITH DONALD O ,  SLISKI ALAN P ,  HARTE KENNETH J

IPC: G21K5/02 ,  A61B1/00 ,  A61N5/10 ,  G01N23/083 ,  G21K5/00 ,  G21K5/04 ,  G21K5/10 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

Abstract: The present invention is directed to an x-ray source for irradiating a surface defining a body cavity in accordance with a predetermined dose distribution. The source comprises a housing, an elongated tubular probe, a target assembly, and an inflatable balloon. The housing encloses an electron beam source and includes elements for generating an electron beam along a beam path. The tubular probe extends along a central axis from the housing about the beam path. The target assembly extends along the central axis and is coupled to the end of the probe distal from the housing. The target assembly includes a target element is positioned in the beam path. The target element is adapted to emit x-rays in response to electrons incident thereon from the beam. The probe tip assembly and associated control electronics include elements for positioning the target element in the beam path, and is substantially x-ray transparent. The balloon is affixed to the distal end of the probe and is inflatable so that when that probe end is inserted into a body cavity, the balloon may be inflated to stretch the cavity to a known shape. Positioning the probe tip inside the inflated balloon allows delivery of a uniform, or other desired, dose of radiation to the surface defining a body cavity.

公开(公告)号：AU2967695A

公开(公告)日：1996-02-09

申请号：AU2967695

申请日：1995-07-11

Applicant: PHOTOELECTRON CORP

Inventor： SMITH DONALD O ,  SLISKI ALAN P ,  HARTE KENNETH J

IPC: G21K5/02 ,  A61B1/00 ,  A61N5/10 ,  G01N23/083 ,  G21K5/00 ,  G21K5/04 ,  G21K5/10 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

Abstract: The present invention is directed to an x-ray source for irradiating a surface defining a body cavity in accordance with a predetermined dose distribution. The source comprises a housing, an elongated tubular probe, a target assembly, and an inflatable balloon. The housing encloses an electron beam source and includes elements for generating an electron beam along a beam path. The tubular probe extends along a central axis from the housing about the beam path. The target assembly extends along the central axis and is coupled to the end of the probe distal from the housing. The target assembly includes a target element is positioned in the beam path. The target element is adapted to emit x-rays in response to electrons incident thereon from the beam. The probe tip assembly and associated control electronics include elements for positioning the target element in the beam path, and is substantially x-ray transparent. The balloon is affixed to the distal end of the probe and is inflatable so that when that probe end is inserted into a body cavity, the balloon may be inflated to stretch the cavity to a known shape. Positioning the probe tip inside the inflated balloon allows delivery of a uniform, or other desired, dose of radiation to the surface defining a body cavity.

公开(公告)号：AU1686295A

公开(公告)日：1995-08-08

申请号：AU1686295

申请日：1995-01-19

Applicant: PHOTOELECTRON CORP

Inventor： DINSMORE MARK T ,  HARTE KENNETH J ,  SLISKI ALAN P ,  SMITH DONALD O ,  OETTINGER PETER E

IPC: A61B19/00 ,  A61N5/10 ,  H01B11/22 ,  H01J35/00 ,  H01J35/06 ,  H01J35/08 ,  H01J35/14 ,  H01J35/30 ,  H01J35/32 ,  H05G1/00 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34

Abstract: This invention is directed to an x-ray source comprising a housing (12), a power supply (12A), an elongated tubular probe (14), a target assembly (26), and a beam steering assembly (29). The housing encloses an electron beam source (22), and has elements for generating an electron beam along a beam path. The power supply (12A) is programmable to control the voltage, current and timing of assembly (26) extends along the central axis and is adapted for coupling to end of the probe (14) distal from the housing (12). The target assembly (26) includes target element (26A) positioned along the beam path, wherein the target element (26A) is adapted to emit x-rays in a predetermined spectral range in response to incident electrons. The beam steering assembly (29) includes a deflection element (30), a feedback network (31) and a deflection controller (144). The deflection element (30) deflects the beam from a nominal axis to a selected surface region on the target element (26) in response to a deflection control signal. The feedback network (31) includes deflection sensing elements for sensing the deflection of the beam and elements for generating feedback signal representative thereof.

公开(公告)号：AU7484094A

公开(公告)日：1995-02-28

申请号：AU7484094

申请日：1994-08-05

Applicant: PHOTOELECTRON CORP

Inventor： SMITH DONALD O ,  DINSMORE MARK T

IPC: A61N5/10 ,  H01J35/08 ,  H01J35/30 ,  H01J35/32 ,  H05G1/06 ,  H05G1/10 ,  H05G1/32 ,  H05G1/34 ,  A61B6/00 ,  A61M36/00 ,  G01T1/161

Abstract: A method of treating brain tumors in a patient, comprising the steps of: identifying and locating a brain tumor in vivo by affixing a stereotactic frame to the head of the patient, performing a computer tomographic (CT) scan of the skull of the patient to determine the location, size, and shape of the tumor with respect to the stereotactic frame, performing a biopsy by inserting an extraction tool along a path measured with respect to the frame to the tumor location, extracting a tissue from the location, removing the needle and the extracted tissue and analyzing the tissue; implanting at least a portion of an adjustable x-ray radiation source in the patient proximate the tumor, the adjustable radiation source including an electron beam source outside the head of the patient, and directing an electron beam produced by the source outside the head of the patient along the path to the location; and controlling the source to generate an x-ray radiation pattern characterized by a spatial and temporal distribution, to selectively irradiate the tumor.

公开(公告)号：CA2234276C

公开(公告)日：2000-05-30

申请号：CA2234276

申请日：1996-10-04

Applicant: PHOTOELECTRON CORP

Inventor： SMITH DONALD O ,  SLISKI ALAN P ,  DALTERIO MICHAEL

IPC: A61N5/10 ,  G01T1/00 ,  G01T1/161 ,  G01T1/29

Abstract: This invention is a phantom apparatus (10) for measuring the radiation dose distribution produced by a brachy-therapy device used to treat a localized area with radiation. The brachy-therapy device includes an insertable probe (24) capable of producing predefined radiation dose geometries about a predefined point. The phantom apparatus (10) includes a tank (12) containing a medium having a radiological equivalent characteristic of the localized area to be treated. The phantom apparatus (10) also includes a radiation sensor (32) for measuring the radiation dose and a positioning system for moving the probe (24) with respect to the radiation sensor (32). The radiation sensor (32) is also coupled to a positioning system (50) to orient the sensor (32) for optimal dose measurements. The phantom apparatus (10) includes a control system (160) that coordinates the movements of the probe (24) and the radiation sensor (32) to avoid a collision. The control system (160) moves the probe (24) along a predefined path around radiation sensor (32) and records the dose at predefined points along the path. In order to reduce the settling time of the sensor (32), the path is selected to coincide with the isodose contours of the radiation dose distribution of the probe (24).