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    THE APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND
    1.
    发明申请
    THE APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND 审中-公开
    使用CUCURBITURIL衍生物和配子之间的非共价键的应用

    公开(公告)号：WO2007046575A1

    公开(公告)日：2007-04-26

    申请号：PCT/KR2006/000687

    申请日：2006-02-28

    Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

    Inventor： KIM, Kimoon ,  BAEK, Kangkyun ,  KIM, Jeeyoun ,  HWANG, Ilha ,  KO, Young-Ho ,  SELVAPALAM, Narayanan ,  NAGARAJAN, Erumaipatty R. ,  PARK, Kyeng-Min

    IPC: C07D487/04

    CPC classification number: C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    Abstract translation: 本发明提供了一种试剂盒，其包括第一组分，其为下式结合于第一材料的式（1）化合物，第二组分为与第二材料结合的配体，其中第一和第二材料中的每一种独立地选自 由固相，生物分子，抗氧化剂，化学治疗剂，抗组胺药，葫芦巴树枝状大分子，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环戊烷衍生物，环肽衍生物， 金属离子，发色团，荧光材料，荧光体，放射性材料和催化剂; 并且配体可以非共价结合式（1）的化合物; 使用与固相结合的式（1）化合物分离和纯化与配体结合的材料的方法; 使用与固相结合的配体分离和纯化式（1）化合物或与化合物结合的物质的方法; 包含与第一材料结合的式（1）化合物和与第二材料结合的配体的传感器芯片; 和包含与第一材料结合的式（1）化合物和与第二材料结合的配体的固体催化剂络合物。

    STATIONARY PHASE AND COLUMN USING CUCURBITURIL BONDED SILICA GEL, AND SEPARATION METHOD OF TAXOL USING THE COLUMN
    3.
    发明申请
    STATIONARY PHASE AND COLUMN USING CUCURBITURIL BONDED SILICA GEL, AND SEPARATION METHOD OF TAXOL USING THE COLUMN 审中-公开
    使用CUCURBITURIL粘结二氧化硅凝胶的固定相和柱，以及使用柱的TAXOL分离方法

    公开(公告)号：WO2007111390A1

    公开(公告)日：2007-10-04

    申请号：PCT/KR2006/001096

    申请日：2006-03-24

    Applicant: POSTECH FOUNDATION ,  POSTECH ACADEMY-INDUSTRY FOUNDATION ,  KIM, Kimoon ,  KO, Young-Ho ,  PARK, Kyeng-Min ,  SELVAPALAM, Narayanan ,  NAGARAJAN, Erumaipatty, R.

    Inventor： KIM, Kimoon ,  KO, Young-Ho ,  PARK, Kyeng-Min ,  SELVAPALAM, Narayanan ,  NAGARAJAN, Erumaipatty, R.

    IPC: C07D305/14 ,  C07D487/04

    CPC classification number: C07D487/04 ,  B01J20/286 ,  C07D305/14

    Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica g el, and a method of separating taxane using the column. The taxane separation meth od includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represen ted by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formul a 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; ap plying the taxane-containing solution to the column; supplying a mobile-phase solvent t o the column to obtain a taxane extract from the column; and purifying taxane from the t axane extract. Therefore, highly purified taxane can be separated from a low-purity cr ude taxane extract.

    Abstract translation: 提供了使用葫芦巴结合二氧化硅的固定相和柱，以及使用该柱分离紫杉烷的方法。 紫杉烷分离方法包括：制备紫杉烷分离柱，柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴共价结合到由 Formul a 3; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含有紫杉烷的溶液置于色谱柱上; 在柱上供应流动相溶剂以从塔中获得紫杉烷提取物; 并从t轴提取物中纯化紫杉烷。 因此，高纯度紫杉烷可与低纯度紫杉烷提取物分离。

    THE APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND
    6.
    发明公开
    THE APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND 有权
    申请的甲CUCURBITURIILDERIVAT和配体之间的非共价键的

    公开(公告)号：EP1951723A1

    公开(公告)日：2008-08-06

    申请号：EP06716137.2

    申请日：2006-02-28

    Applicant: Postech Academy-Industry Foundation

    Inventor： KIM, Kimoon ,  BAEK, Kangkyun ,  KIM, Jeeyoun ,  HWANG, Ilha ,  KO, Young-Ho ,  SELVAPALAM, Narayanan ,  NAGARAJAN, Erumaipatty R. ,  PARK, Kyeng-Min

    IPC: C07D487/04

    CPC classification number: C07D487/22 ,  B01D15/3804 ,  B01J31/0249 ,  B01J31/0251 ,  B01J31/1658 ,  B82Y5/00 ,  B82Y15/00 ,  C07K1/22

    Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of formula (1) bound to a first material and a ligand bound to a second material; and a solid-catalyst complex including the compound of formula (1) bound to a first material and a ligand bound to a second material.

    Abstract translation: 本发明提供一种试剂盒，其包括第一组分没有被式（1）下面结合的化合物的第一材料，并从所选择的第二组分也被绑定到第二材料的配体，worin每个第一和第二材料中的是unabhängig 组由固体相，生物分子的，衍生的抗氧化剂，化学治疗剂，抗组胺剂，葫芦脲树枝状聚合物，环糊精衍生物，冠醚衍生物，杯芳烃衍生物，环芳衍生物，环肽， 金属离子，生色团，荧光材料，磷酸盐，放射性材料，和催化剂; 和配体可以非共价结合于式（1）化合物; 分离和纯化绑定到使用式的化合物的配体的材料的方法（1）结合于固相; 分离和纯化的式（1）的化合物或结合使用结合于固相上的配位体的化合物的材料的方法; 传感器芯片，包括下式的化合物（1）结合到第一材料和结合到第二材料的配体; 和固体催化剂络合物包括式（1）化合物结合到第一材料和结合到第二材料的配体。

    STATIONARY PHASE AND COLUMN USING CUCURBITURIL BONDED SILICA GEL, AND SEPARATION METHOD OF TAXOL USING THE COLUMN
    8.
    发明授权
    STATIONARY PHASE AND COLUMN USING CUCURBITURIL BONDED SILICA GEL, AND SEPARATION METHOD OF TAXOL USING THE COLUMN 有权
    酞菁键合硅胶固定相和柱状物及紫杉醇柱分离方法的研究

    公开(公告)号：EP1999122B1

    公开(公告)日：2010-11-24

    申请号：EP06732696.7

    申请日：2006-03-24

    Applicant: Postech Foundation ,  Postech Academy-Industry Foundation

    Inventor： KIM, Kimoon ,  KO, Young-Ho ,  PARK, Kyeng-Min ,  SELVAPALAM, Narayanan ,  NAGARAJAN, Erumaipatty, R.

    IPC: C07D305/14 ,  C07D487/04

    CPC classification number: C07D487/04 ,  B01J20/286 ,  C07D305/14

    Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica g el, and a method of separating taxane using the column. The taxane separation meth od includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represen ted by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formul a 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; ap plying the taxane-containing solution to the column; supplying a mobile-phase solvent t o the column to obtain a taxane extract from the column; and purifying taxane from the t axane extract. Therefore, highly purified taxane can be separated from a low-purity cr ude taxane extract.

    Abstract translation: 提供了使用葫芦脲结合硅胶的固定相和柱以及使用该柱分离紫杉烷的方法。 紫杉烷分离方法包括：制备紫杉烷分离柱，所述柱填充有包含葫芦脲结合硅胶的固定相，其中由式1或2代表的葫芦脲与由以下代表的改性硅胶共价结合： Formul a 3; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含有紫杉烷的溶液加入柱中; 向柱提供流动相溶剂以从柱中获得紫杉烷提取物; 并从泰山提取物中纯化紫杉烷。 因此，高纯度紫杉烷可以从低纯度紫杉烷萃取物中分离出来。

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