公开(公告)号：WO1989009815A1

公开(公告)日：1989-10-19

申请号：PCT/US1989001379

申请日：1989-04-04

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  SHAW, George, M. ,  HAHN, Beatrice, H. ,  KONG, Lilly, I. ,  LEE, Shei-Wen

IPC: C12N01/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/1045 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16122 ,  C12Q1/703

Abstract: The present invention relates to a novel virus, said virus belonging to the HIV-2 family of viruses. In particular, the invention relates to a retrovirus characterized by being antigenically more similar to, but genetically distinct from, HIV-2/ROD and SIVMAC than to HIV-1. More particularly, the present invention relates to the isolation and cultivation of HIV-2/ST thereby providing a source of said virus and its derivatives including virus-derived antigens and derivatives and parts thereof, useful in the development of diagnostic assays for said virus or other related viruses belonging to the HIV-2 family. Furthermore, the present invention is also directed to recombinant DNA molecules containing the entire HIV-2/ST provirus thereby providing a source of recombinant viral components useful in the development of said diagnostic assays for HIV-2 viruses. The present invention is also directed to antibodies specific to viral components and to different antibodies specific to the first antibodies, said antibodies are also useful in the development of diagnostic assays for HIV-2 viruses. The present invention also contemplates a method of the isolation of HIV-2/ST-type viruses.

Abstract translation: 本发明涉及一种新型病毒，所述病毒属于HIV-2病毒家族。 特别地，本发明涉及一种逆转录病毒，其特征在于与HIV-1相比，其在抗原上与HIV-2 / ROD和SIVMAC更相似，但在遗传上不同。 更具体地，本发明涉及HIV-2 / ST的分离和培养，从而提供所述病毒及其衍生物的来源，所述病毒及其衍生物包括病毒衍生抗原及其衍生物及其部分，可用于开发用于所述病毒的诊断测定或 属于HIV-2家族的其他相关病毒。 此外，本发明还涉及含有整个HIV-2 / ST原病毒的重组DNA分子，从而提供可用于开发用于HIV-2病毒的所述诊断测定的重组病毒组分的来源。 本发明还涉及针对病毒组分和针对第一抗体特异性的不同抗体的抗体，所述抗体也可用于开发用于HIV-2病毒的诊断测定。 本发明还考虑了分离HIV-2 / ST型病毒的方法。