公开(公告)号：WO1996040786A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009422

申请日：1996-06-07

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  CENTER, David, M. ,  CRUIKSHANK, William, W. ,  KORNFELD, Hardy

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K38/2013 ,  C07K14/5446 ,  C07K16/22 ,  C07K16/24 ,  C07K2317/73 ,  Y10S435/974 ,  Y10S435/975 ,  A61K2300/00

Abstract: Disclosed is a substantially pure antibody which specifically binds an LCF polypeptide and methods of using such antibodies.

Abstract translation: 公开了特异性结合LCF多肽的基本上纯的抗体以及使用这种抗体的方法。

公开(公告)号：EP0832132A1

公开(公告)日：1998-04-01

申请号：EP96918305.0

申请日：1996-06-07

Applicant: Research Corporation Technologies, Inc

Inventor： CENTER, David, M. ,  CRUIKSHANK, William, W. ,  KORNFELD, Hardy

IPC: A61K38 ,  C07K14 ,  C07K16

CPC classification number: C07K16/244 ,  A61K38/2013 ,  C07K14/5446 ,  C07K16/22 ,  C07K16/24 ,  C07K2317/73 ,  Y10S435/974 ,  Y10S435/975 ,  A61K2300/00

Abstract: Disclosed is a substantially pure antibody which specifically binds an LCF polypeptide and methods of using such antibodies.

Abstract translation: 公开了特异性结合LCF多肽的基本上纯的抗体和使用这种抗体的方法。

公开(公告)号：EP0832132B1

公开(公告)日：2003-08-27

申请号：EP96918305.2

申请日：1996-06-07

Applicant: Research Corporation Technologies, Inc

Inventor： CENTER, David, M. ,  CRUIKSHANK, William, W. ,  KORNFELD, Hardy

IPC: C07K16/24 ,  A61K39/395 ,  A61K38/20 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K16/244 ,  A61K38/2013 ,  C07K14/5446 ,  C07K16/22 ,  C07K16/24 ,  C07K2317/73 ,  Y10S435/974 ,  Y10S435/975 ,  A61K2300/00

Abstract: Disclosed is a substantially pure antibody which specifically binds an LCF polypeptide and methods of using such antibodies.

公开(公告)号：EP1212363A2

公开(公告)日：2002-06-12

申请号：EP00952503.1

申请日：2000-08-04

Applicant: Research Corporation Technologies, Inc

Inventor： CENTER, David, M. ,  CRUIKSHANK, William, W. ,  KORNFELD, Hardy

IPC: C07K14/54 ,  C07K16/24 ,  C12N15/24 ,  A61K38/20 ,  A61P29/00

CPC classification number: A61K38/13 ,  A61K31/00 ,  A61K38/00 ,  A61K39/395 ,  A61K45/06 ,  C07K14/5446 ,  A61K2300/00

Abstract: The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acid in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.