公开(公告)号：WO1996030042A2

公开(公告)日：1996-10-03

申请号：PCT/US1996004054

申请日：1996-03-26

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  McFADDEN, D., Grant ,  LUCAS, Alexandra

IPC: A61K38/57

CPC classification number: A61K38/55 ,  C07K14/8121

Abstract: Compositions and methods for treating inflammatory cell infiltration in a tissue of a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1, SERP-1 analog or biologically active fragment thereof admixed with a pharmaceutically acceptable carrier to a subject in need of such treatment. Biologically active SERP-1 analogs are also provided. The compositions and methods of the present invention are useful for treating numerous inflammatory based diseases and injuries.

Abstract translation: 提供了用于治疗哺乳动物受试者的组织中的炎性细胞浸润的组合物和方法。 该方法包括给予需要这种治疗的受试者施用治疗有效量的与药学上可接受的载体混合的SERP-1，SERP-1类似物或其生物活性片段。 还提供了生物活性的SERP-1类似物。 本发明的组合物和方法可用于治疗许多基于炎症的疾病和损伤。

公开(公告)号：EP0817646A2

公开(公告)日：1998-01-14

申请号：EP96909862.0

申请日：1996-03-26

Applicant: Research Corporation Technologies, Inc

Inventor： McFADDEN, D., Grant ,  LUCAS, Alexandra

IPC: C12N15 ,  A61K38 ,  A61P1 ,  A61P3 ,  A61P9 ,  A61P11 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07K14 ,  C12P21

CPC classification number: A61K38/55 ,  C07K14/8121

Abstract: Compositions and methods for treating inflammatory cell infiltration in a tissue of a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1, SERP-1 analog or biologically active fragment thereof admixed with a pharmaceutically acceptable carrier to a subject in need of such treatment. Biologically active SERP-1 analogs are also provided. The compositions and methods of the present invention are useful for treating numerous inflammatory based diseases and injuries.