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1.发明申请METHODS AND COMPOSITIONS FOR DELAYING OR PREVENTING THE ONSET OF AUTOIMMUNE DISEASE 审中-公开延迟或预防自发性疾病发作的方法和组合
公开(公告)号：WO1994023737A1
公开(公告)日：1994-10-27
申请号：PCT/US1994004179
申请日：1994-04-15
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: A61K37/02
CPC classification number: A61K38/51 , A61K38/26 , A61K38/28 , A61K2300/00
Abstract: The subject invention concerns compositions and methods useful for the prevention or amelioration of autoimmune diseases. Specifically exemplified are compositions and methods useful in immunizing to delay or prevent insulin dependent diabetes. In a preferred embodiment, diabetes is prevented or delayed by the parenteral administration of a composition comprising specific antigenic peptides of B-chain insulin and further comprising incomplete Freund's adjuvant. The specifically exemplified insulin B-chain composition stimulates the immune response, and depresses the synthesis of cytotoxic lymphokines in the target tissue.
Abstract translation: 本发明涉及可用于预防或改善自身免疫疾病的组合物和方法。 具体示例的是用于免疫延迟或预防胰岛素依赖性糖尿病的组合物和方法。 在优选的实施方案中，通过胃肠外给药包含B链胰岛素的特异性抗原肽的组合物并进一步包含不完全弗氏佐剂来预防或延迟糖尿病。 具体示例的胰岛素B链组合物刺激免疫应答，并抑制靶组织中细胞毒性淋巴因子的合成。
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2.发明授权METHODS AND COMPOSITIONS FOR DELAYING OR PREVENTING THE ONSET OF AUTOIMMUNE DISEASE 失效方法和延迟制剂或预防自身免疫性疾病
公开(公告)号：EP0693933B1
公开(公告)日：2002-06-26
申请号：EP94914804.3
申请日：1994-04-15
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
Inventor： MACLAREN, Noel K., University of Florida , MUIR, Andrew
CPC classification number: A61K38/51 , A61K38/26 , A61K38/28 , A61K2300/00
Abstract: The subject invention concerns compositions and methods useful for the prevention or amelioration of autoimmune diseases. Specifically exemplified are compositions and methods useful in immunizing to delay or prevent insulin dependent diabetes. In a preferred embodiment, diabetes is prevented or delayed by the parenteral administration of a composition comprising specific antigenic peptides of B-chain insulin and further comprising incomplete Freund's adjuvant. The specifically exemplified insulin B-chain composition stimulates the immune response, and depresses the synthesis of cytotoxic lymphokines in the target tissue.
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3.发明公开METHODS AND COMPOSITIONS FOR DELAYING OR PREVENTING THE ONSET OF AUTOIMMUNE DISEASE 失效程序及ZUBEREIRTUNGEN是一种自动免疫疾病的延迟或预防
公开(公告)号：EP0693933A1
公开(公告)日：1996-01-31
申请号：EP94914804.0
申请日：1994-04-15
Applicant: Research Corporation Technologies, Inc.
Inventor： MACLAREN, Noel K., University of Florida , MUIR, Andrew
CPC classification number: A61K38/51 , A61K38/26 , A61K38/28 , A61K2300/00
Abstract: The subject invention concerns compositions and methods useful for the prevention or amelioration of autoimmune diseases. Specifically exemplified are compositions and methods useful in immunizing to delay or prevent insulin dependent diabetes. In a preferred embodiment, diabetes is prevented or delayed by the parenteral administration of a composition comprising specific antigenic peptides of B-chain insulin and further comprising incomplete Freund's adjuvant. The specifically exemplified insulin B-chain composition stimulates the immune response, and depresses the synthesis of cytotoxic lymphokines in the target tissue.
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