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1.发明申请RESISTANCE TO VIRUSES AND VIROIDS IN TRANSGENIC PLANT AND ANIMAL HOSTS EXPRESSING dsRNA-BINDING PROTEIN 审中-公开在转基因植物和动物宿主中对病毒和VIROIDS的抗性表达dsRNA结合蛋白
公开(公告)号：WO1996040948A2
公开(公告)日：1996-12-19
申请号：PCT/US1996008503
申请日：1996-06-04
Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC: C12N15/82
CPC classification number: C12N15/8509 , A01K2217/05 , A01K2267/02 , A01K2267/0337 , A61K38/00 , A61K48/00 , C07K14/005 , C12N15/8283 , C12N2710/24122 , C12N2720/12322
Abstract: The invention provides a method for imparting resistance in animals to viruses, and in plants to viruses and viroids, that express double-stranded RNA-like structures (dsRNAs). This method enables the binding of pathogenic dsRNAs during the infection process by expression of dsRNA-binding protein in transgenic animal and plant hosts, thus interrupting the infection cycle and inhibiting disease. The presence of a dsRNA-binding protein in a transgenic host renders the transgenic host resistant to the phenotypic symptoms of viral infection and/or decreased pathogen replication. Accordingly, the present invention provides a genetically engineered animal and plant, stably transformed to express a dsRNA-binding protein, such that the transgenic host displays resistance to virus and/or viroid challenge.
Abstract translation: 本发明提供了一种赋予动物对病毒和植物中表达双链RNA样结构（dsRNA）的病毒和类病毒的抗性的方法。 该方法能够在感染过程中通过在转基因动物和植物宿主中表达dsRNA结合蛋白来结合病原性dsRNA，从而中断感染周期并抑制疾病。 在转基因宿主中dsRNA结合蛋白的存在使转基因宿主对病毒感染的表型症状和/或病原体复制减少具有抗性。 因此，本发明提供了稳定转化以表达dsRNA结合蛋白的基因工程动物和植物，使得转基因宿主显示出对病毒和/或类病毒攻击的抗性。
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2.发明公开RESISTANCE TO VIRUSES AND VIROIDS IN TRANSGENIC PLANT AND ANIMAL HOSTS EXPRESSING dsRNA-BINDING PROTEIN 失效抗病毒和类病毒转基因植物和动物的双链RNA结合蛋白表达
公开(公告)号：EP0832260A2
公开(公告)日：1998-04-01
申请号：EP96917955.0
申请日：1996-06-04
Applicant: Research Corporation Technologies, Inc
Inventor： ROTH, Don, Allen , LANGLAND, Jeffrey Olaf
CPC classification number: C12N15/8509 , A01K2217/05 , A01K2267/02 , A01K2267/0337 , A61K38/00 , A61K48/00 , C07K14/005 , C12N15/8283 , C12N2710/24122 , C12N2720/12322
Abstract: The invention provides a method for imparting resistance in animals to viruses, and in plants to viruses and viroids, that express double-stranded RNA-like structures (dsRNAs). This method enables the binding of pathogenic dsRNAs during the infection process by expression of dsRNA-binding protein in transgenic animal and plant hosts, thus interrupting the infection cycle and inhibiting disease. The presence of a dsRNA-binding protein in a transgenic host renders the transgenic host resistant to the phenotypic symptoms of viral infection and/or decreased pathogen replication. Accordingly, the present invention provides a genetically engineered animal and plant, stably transformed to express a dsRNA-binding protein, such that the transgenic host displays resistance to virus and/or viroid challenge.
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