公开(公告)号：WO1992006989A1

公开(公告)日：1992-04-30

申请号：PCT/US1991007280

申请日：1991-10-04

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  VAFAI, Abbas

IPC: C07H15/12

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/088 ,  C12N2710/16722 ,  G01N33/56983

Abstract: The present invention relates to the construction of a recombinant plasmid which is capable of expressing a secretory truncated glycoprotein (Tgp) of Varicella-zoster virus (BZV) in mammalian cells. The secretory Tgp of the present invention contains at least one epitope capable of inducing antibody response. the present invention comtemplates the production and utilization of this secretory Tgp in a vaccine against chickenpox and/or shingles. The present invention is also directed towards the use of the secretory Tgp in diagnostic assays for detection of VZV. The present invention is also directed to first antibodies specific to secretory Tgp and to second antibodies specific to the first antibodies. These second antibodies are also useful in diagnostic assays for VZV.

Abstract translation: 本发明涉及能够在哺乳动物细胞中表达水痘带状疱疹病毒（BZV）的分泌截短的糖蛋白（Tgp）的重组质粒的构建。 本发明的分泌Tgp含有至少一种能诱导抗体应答的表位。 本发明考察了在针对水痘和/或带状疱疹的疫苗中该分泌型Tgp的产生和利用。 本发明还涉及在用于检测VZV的诊断测定中使用分泌型Tgp。 本发明还涉及对分泌型Tgp特异性的第一抗体和针对第一抗体特异性的第二抗体。 这些第二抗体也可用于VZV的诊断测定。

公开(公告)号：EP0504388B1

公开(公告)日：2000-09-06

申请号：EP91919890.3

申请日：1991-10-04

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： VAFAI, Abbas

IPC: C12N15/38 ,  C07K14/04 ,  A61K39/25 ,  C12Q1/70 ,  G01N33/569

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/088 ,  C12N2710/16722 ,  G01N33/56983

Abstract: The present invention relates to the construction of a recombinant plasmid which is capable of expressing a secretory truncated glycoprotein (Tgp) of Varicella-zoster virus (BZV) in mammalian cells. The secretory Tgp of the present invention contains at least one epitope capable of inducing antibody response. the present invention comtemplates the production and utilization of this secretory Tgp in a vaccine against chickenpox and/or shingles. The present invention is also directed towards the use of the secretory Tgp in diagnostic assays for detection of VZV. The present invention is also directed to first antibodies specific to secretory Tgp and to second antibodies specific to the first antibodies. These second antibodies are also useful in diagnostic assays for VZV.

公开(公告)号：EP0504388A1

公开(公告)日：1992-09-23

申请号：EP91919890.0

申请日：1991-10-04

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： VAFAI, Abbas

IPC: A61K38 ,  A61K39 ,  A61K49 ,  A61P37 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  G01N33 ,  C12R1

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/088 ,  C12N2710/16722 ,  G01N33/56983

Abstract: L'invention concerne l'élaboration d'un plasmide recombiné capable d'exprimer une glycoprotéine tronquée secrétoire (Tgp) d'herpès virus varicellae (VZV) dans des cellules mammifères. La (Tgp) secrétoire de l'invention contient au moins un épitope capable d'induire une réponse d'anticorps. L'invention concerne la production et l'utilisation de cette (Tgp) secrétoire dans un vaccin contre la varicelle ou le zona. L'invention concerne également l'emploi de la (Tgp) secrétoire dans des dosages diagnostiques utilisés dans la détection de l'herpès virus varicellae. L'invention concerne en outre des premiers anticorps spécifiques de la Tgp secrétoire ainsi que des seconds anticorps spécifiques des premiers anticorps. Ces seconds anticorps sont également utilisés dans des dosages diagnostiques de l'herpès virus varicellae.