公开(公告)号：WO1992000757A1

公开(公告)日：1992-01-23

申请号：PCT/US1991004832

申请日：1991-07-09

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  ZAIN, Sayeeda ,  LUKANIDIN, Eugene

IPC: A61K39/395

CPC classification number: C07K14/4728 ,  A61K38/00 ,  C07K16/18

Abstract: The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.

Abstract translation: 本发明涉及通过检测由mts-1基因编码的mts-1 mRNA或mts-1蛋白来诊断恶性肿瘤。 本发明考虑使用针对mts-1蛋白的重组mts-1 DNA和抗体来诊断几种类型的肿瘤细胞（包括例如甲状腺，上皮，肺，肝和肾）肿瘤细胞的转移潜能。 本发明还涉及哺乳动物细胞系和具有高和低转移潜力的肿瘤，其被开发用作用于体外和体内抗转移药物筛选的有用的模型系统。

公开(公告)号：WO1995020656A1

公开(公告)日：1995-08-03

申请号：PCT/US1995001214

申请日：1995-01-31

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  ZAIN, Sayeeda ,  LUKANIDIN, Eugene

IPC: C12N15/12

CPC classification number: C07K14/4728 ,  A61K38/00 ,  C07K16/18 ,  C07K2319/00 ,  C12N2799/026 ,  Y10S435/81

Abstract: The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.

Abstract translation: 本发明涉及通过检测由mts-1 mRNA编码的mts-1mRNA或mts-1蛋白来诊断恶性肿瘤， / u基因。 本发明考虑使用重组mts-1 DNA和针对mts-1蛋白的抗体来诊断几种类型的肿瘤细胞的转移潜能，包括对于 例如甲状腺，上皮，肺，肝，肾等肿瘤细胞。 本发明还涉及哺乳动物细胞系和具有高和低转移潜力的肿瘤，其已被开发用作在体外和/或体外的有用的模型系统 抗转移药物筛选。

公开(公告)号：EP0566571B1

公开(公告)日：1997-05-07

申请号：EP91915859.2

申请日：1991-07-09

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： ZAIN, Sayeeda ,  LUKANIDIN, Eugene

IPC: A61K39/395 ,  C07K7/00 ,  C07K16/00 ,  C07H21/04

CPC classification number: C07K14/4728 ,  A61K38/00 ,  C07K16/18

Abstract: The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.

公开(公告)号：EP0734442A1

公开(公告)日：1996-10-02

申请号：EP95909390.0

申请日：1995-01-31

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： ZAIN, Sayeeda ,  LUKANIDIN, Eugene

IPC: G01N33 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P35 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12R1

CPC classification number: C07K14/4728 ,  A61K38/00 ,  C07K16/18 ,  C07K2319/00 ,  C12N2799/026 ,  Y10S435/81

Abstract: The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.

公开(公告)号：EP0566571A1

公开(公告)日：1993-10-27

申请号：EP91915859.0

申请日：1991-07-09

Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

Inventor： ZAIN, Sayeeda ,  LUKANIDIN, Eugene

IPC: A61K31 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P1 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P17 ,  A61P35 ,  C07K7 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  G01N33 ,  C12R1

CPC classification number: C07K14/4728 ,  A61K38/00 ,  C07K16/18

Abstract: Cette invention concerne le diagnostic d'un cancer malin au moyen de la détection de l'ARNm mts-1 ou de la protéine mts-1, codés par le gène mts-1. On peut utiliser de l'ARN mts-1 recombinant et des anticorps dirigés contre la protéine mts-1 pour diagnostiquer la potentialité métastatique de plusieurs types de cellules tumorales, parmi lesquelles on trouve, par exemple, des cellules tumorales de la thyroïde, de l'épithélium, des poumons, du foie et des reins. Cette invention concerne également des tumeurs et des lignées cellulaires de mammifères ayant des potentialités métastatiques élevées ou faibles qu'on a developpées pour servir de systèmes de modèles utiles pour la recherche d'un médicament antimétastatique in vitro et in vivo.

Abstract translation: 本发明涉及通过检测由mts-1基因编码的mts-1mRNA或mts-1蛋白来诊断恶性癌症。 可用于针对MTS-1蛋白的MTS-1重组RNA和抗体来诊断几种类型的肿瘤细胞，其中有，例如，甲状腺肿瘤细胞的转移潜力 上皮，肺，肝脏和肾脏。 本发明还涉及具有高或低转移潜能的肿瘤和哺乳动物细胞系，其已被开发用作体外和体内检测抗转移药物的有用模型系统。