公开(公告)号：SE7611727A

公开(公告)日：1976-10-21

申请号：SE7611727

申请日：1976-10-21

Applicant: RHONE POULENC SA

Inventor： BOUCHAUDON J ,  LE ROY R ,  MESSER M N

IPC: A61K31/43 ,  A61K31/431 ,  A61P31/04 ,  C07D20060101 ,  C07D205/08 ,  C07D233/40 ,  C07D277/06 ,  C07D499/00 ,  C07D499/04 ,  C07D499/10 ,  C07D499/12 ,  C07D499/44 ,  C07D499/46 ,  C07D499/54 ,  C07D499/64 ,  C07D499/68 ,  C07D499/80

CPC classification number: C07D499/68 ,  C07D499/80

公开(公告)号：SE7611727L

公开(公告)日：1976-10-21

申请号：SE7611727

申请日：1976-10-21

Applicant: RHONE POULENC SA

Inventor： BOUCHAUDON J ,  LE ROY R ,  MESSER M N

IPC: A61K31/43 ,  A61K31/431 ,  A61P31/04 ,  C07D20060101 ,  C07D205/08 ,  C07D233/40 ,  C07D277/06 ,  C07D499/00 ,  C07D499/04 ,  C07D499/10 ,  C07D499/12 ,  C07D499/44 ,  C07D499/46 ,  C07D499/54 ,  C07D499/64 ,  C07D499/68 ,  C07D499/80

Abstract: Ampicillin is prepared by reacting an inorganic or organic base with a new penicillin G derivative of the formula: OHS ¦ ANGLE CH3 C6H5-CH2-C---N----CH-CHC ANGLE ¦¦¦¦¦CH3 R2O-CS-NC=OO=C--N---CH-COOR1 ANGLE CH ¦ C6H5 (wherein R1 represents a group protecting the carboxy radical and R2 represents a strong electron-attracting group, e.g. a halogenoethyl group) to open the imidazolidine ring and give an intermediate product of the formula: S ANGLE CH3 R2O-CS-NH-CH-CONH----CH-CHC ANGLE ¦¦¦¦CH3 C6H5O=C--N---CH-COOR1 and removing by methods known per se the groups -R1 and R2O-CS- which protect the carboxy radical and amine functions respectively.