中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

45 records (took 0.023 seconds)

    Polyoxetanes which can be used in peptide synthesis
    1.
    发明授权
    Polyoxetanes which can be used in peptide synthesis 失效
    可用于肽合成的聚氧乙烯

    公开(公告)号：US3847868A

    公开(公告)日：1974-11-12

    申请号：US33517773

    申请日：1973-02-23

    Applicant: RHONE POULENC SA

    Inventor： BOUCHAUDON J ,  BOURAT G ,  MARGRAFF R

    IPC: C08L71/00 ,  C07K1/04 ,  C08G65/00 ,  C08G65/02 ,  C08G65/329 ,  C08L1/00 ,  C08L27/00 ,  C08G23/04

    CPC classification number: C07K1/042 ,  C08G65/329

    Abstract: 1. A POLYOXETANE WHICH CONSISTS ESSENTIALLY OF A PLURALITY OF UNITS OF THE FORMULA:

    -CH2-C(-CH2-X1)(-CH2-O-AR-CH2-X2)-CH2-O- (I) AND

    -CH2-C(-CH2-X1)2-CH2-O- (II)

    AND, OPTIONALLY, OF UNITS OF AT LEAST ONE OF THE FORMULAE-

    -CH2-C(-CH2-X1)(-CH2-O-AR'')-CH2-O- (III)

    -CH2-C(-CH2-Y1)2-CH2-O- (IV) AND

    -CH2-C(-CH2-Y)(-CH2-O-)-CH2-O-AR-CH2-AR-O-CH2-C(-CH2-Y)

    (-CH2-)-CH2-O-

    IN WHICH: EACH OF X1 AND X2 WHICH MAY BE IDENTICAL OR DIFFERENT, REPRESENTS A CHLORINE, OR BROMINE ATOM, Y IS AS DEFINED UNDER X1 OR REPRESENTS A RADICAL OF FORFERENT, REPRESENTS A -O-AR-CH2X2 OR -O-AR'', EACH OF THE Y1 RADICALS, WHICH MAY BE IDENTICAL OR DIFFERENT REPRESENTS A -O-AR'' OR -O-AR-CH2X2 RADICAL, AR REPRESENTS A DIVALENT AROMATIC RADICAL, THE TWO FREE VALENCIES OF WHICH ARE CARRIED BY CARBON ATOMS OF ONE OR TWO AROMATIC BENZENE RINGS, AND AR'' REPRESENTS THE RADICAL -ARH THE UNITS (I) TO (V) BEING CONNECTED TO ONE ANOTHER VIA THE OXYGEN ATOM WITH A FREE VALENCY OF ONE OF THE UNITS AND A METHYLENE GROUP WITH A FREE VALENCY OF THE ADJACENT UNIT.

    Cyclopeptides derived from polymyxins and their preparation
    2.
    发明授权
    Cyclopeptides derived from polymyxins and their preparation 失效
    从多聚氰胺衍生的环状物及其制备

    公开(公告)号：US3753970A

    公开(公告)日：1973-08-21

    申请号：US3753970D

    申请日：1970-08-04

    Applicant: RHONE POULENC SA

    Inventor： BOUCHAUDON J ,  JOLLES G

    IPC: C07K7/62 ,  C07C103/52 ,  C07G7/00 ,  C08H1/00

    CPC classification number: C07K7/62 ,  Y10S930/19 ,  Y10S930/27

    Abstract: THE NEW CYCLOPEPTIDES OF THE FORMULA:

    DAB
    IN WHICH Y-Z REPRESENTS AN AMINO ACID CHAIN SELECTED FROM D-LEU-THR,D-PHE-LEU, D-LEU-LEU AND D-LEU-ILEU, G REPRESENTS AN AMINO-PROTECTING RADICAL OF THE FORMULA:

    PY-CH(-R)-OOC-

    IN WHICH PY REPRESENTS PYRIDYL, PYRIDYL-N-OXIDE, OR PYRIDYL OR PYRIDYL-N-OXIDE CARRYING A METHYL SUBSTITUENT, R REPRESENTS HYDROGEN, ALKYL OF 1 TO THROUGH 5 CARBON ATOMS, OR PHENYL, AND DAB REPRESENTS A,Y-DIAMINOBUTYRIC AID, THE AMINO ACIDS HAVING THE L-CONFFIGURATION UNLESS OTHERWISE INDICATED, SAID CYCLOPEPTIDES CONTAINING ONLY A SINGLE FREE AMINO GROUP, ARE USEFUL INTERMEDIATES FOR THE SYNTHESIS OF SEMI-SYNTHETIC PRODUCTS DERIVED FROM POLYMYXINS.

    Process for the preparation of cyclopeptides derived from polymyxins
    3.
    发明授权
    Process for the preparation of cyclopeptides derived from polymyxins 失效
    用于制备衍生自多聚霉素的环孢菌素的方法

    公开(公告)号：US3817973A

    公开(公告)日：1974-06-18

    申请号：US22229672

    申请日：1972-01-31

    Applicant: RHONE POULENC SA

    Inventor： BOUCHAUDON J ,  JOLLES G

    IPC: A61K38/00 ,  C07K7/62 ,  C07C103/52 ,  C07G7/00

    CPC classification number: C07K7/62 ,  A61K38/00 ,  Y02P20/55 ,  Y10S930/19 ,  Y10S930/27

    Abstract: D R A W I N G
    WHEREIN A is alkyl of three through 18 carbon atoms optionally substituted by hydroxy, amino or cyano; or alkyl of one through four carbon atoms substituted by a monocyclic or polycyclic alkyl radical or phenyl optionally substituted by halogen or alkoxy; or phenyl optionally substituted by halogen or alkoxy, X is -CO- or -SO2-, and Y-Z is one of the chains D-Phe-Leu, D-Leu-Leu and DLeu-Ileu, are prepared by introducing the grouping A-X-Dab-ThrDab- onto the appropriate cyclopeptide having its amino functions protected. New polymyxins of the said formula have antibiotic properties.
    Polymyxins of the formula

    Abstract translation: 式AD的多粘菌素是任选被羟基，氨基或氰基取代的三至十八个碳原子的烷基; 或被单环或多环烷基取代的一至四个碳原子的烷基或任选被卤素或烷氧基取代的苯基; 或任选被卤素或烷氧基取代的苯基，X是-CO-或-SO 2 - ，Y Z是链D-Phe-Leu，D-Leu-Leu和D-Leu-Ileu之一，通过引入分组 AX-Dab-Thr-Dab-保护其具有氨基功能的适当的环肽。 所述配方的新型多粘菌素具有抗生素特性。

    6.
    发明专利
    未知

    公开(公告)号：DK470074A

    公开(公告)日：1975-05-05

    申请号：DK470074

    申请日：1974-09-05

    Applicant: RHONE POULENC SA

    Inventor： BOUCHAUDON J ,  ROY P L ,  MESSER M N

    IPC: A61K31/43 ,  C07D499/00 ,  C07D499/04 ,  C07D499/46 ,  C07D499/48 ,  C07D499/58 ,  C07D501/10 ,  C07D

    Abstract: 1454587 6-Trichloroacetamido-penicillanic acid derivatives RHONE-POULENC SA 5 Sept 1974 [6 Sept 1973] 38881/74 Heading C2C The invention comprises compounds of the formula wherein R is an ester radical. They may be obtained by either oxidizing the S-atom of a compound of the formula to a sulphoxide group, with, e.g. H 2 O 2 , NaIO 4 or an organic per-acid; or reacting a compound of the formula wherein R 1 is PhCH 2 or PhOCH 2 , with or a derivative thereof. Compounds of Formula II may be obtained either by reacting a compound of the formula with Cl 3 CCOOH or a derivative thereof or by reacting an imino-chloride of the above compound with an alkali metal salt of Cl 3 CCOOH. Compounds of Formula III may be obtained either by oxidation of a compound of Formula IV or by esterification of a compound of the formula

Patent Agency Ranking