公开(公告)号：EP0451948B1

公开(公告)日：1994-12-28

申请号：EP91301972.5

申请日：1991-03-08

Applicant: ROHM AND HAAS COMPANY

Inventor： Shaber, Steven Howard ,  Szapacs, Edward Michael ,  Reynolds, Charles Howard

IPC: C07D213/57 ,  C07D239/26 ,  C07D241/12 ,  A01N43/40 ,  A01N43/54 ,  A01N43/60

CPC classification number: C07D239/26 ,  A01N43/40 ,  A01N43/54 ,  A01N43/60 ,  C07D213/57 ,  C07D241/12

公开(公告)号：EP0451948A1

公开(公告)日：1991-10-16

申请号：EP91301972.5

申请日：1991-03-08

Applicant: ROHM AND HAAS COMPANY

Inventor： Shaber, Steven Howard ,  Szapacs, Edward Michael ,  Reynolds, Charles Howard

IPC: C07D213/57 ,  C07D239/26 ,  C07D241/12 ,  A01N43/40 ,  A01N43/54 ,  A01N43/60

CPC classification number: C07D239/26 ,  A01N43/40 ,  A01N43/54 ,  A01N43/60 ,  C07D213/57 ,  C07D241/12

Abstract: Heterocyclicacetonitriles which are useful in the control of fungi, especially bitunicate asci and unitunicate asci, are provided. These compounds are of the general formula:

wherein Ar₁ and Ar₂ are substituted or unsubstituted aryl groups; Het is a six-membered nitrogen-containing heterocyclic ring; n is the integer 2 or 3; and the agronomically acceptable enantiomorphs, acid addition salts and metal complexes thereof.

Abstract translation: 提供了可用于控制真菌的特异性杂环丙酮，特别是苦味酸和单体酸。 这些化合物具有以下通式：其中Ar 1和Ar 2是取代或未取代的芳基; Het是六元含氮杂环; n是整数2或3; 和农艺学上可接受的对映体，其酸加成盐和金属络合物。

公开(公告)号：EP0234683A1

公开(公告)日：1987-09-02

申请号：EP87300159.8

申请日：1987-01-08

Applicant: ROHM AND HAAS COMPANY

Inventor： Shaber, Steven Howard ,  Fujimoto, Ted Tsutomu

IPC: C07D249/08 ,  A01N43/653

CPC classification number: C07D231/12 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08

Abstract: Alpha- (2-alkoxyphenyl)-alpha-alkyl-1H-1,2,4-­triazole-1-propanenitriles of the formula
wherein X is a hydrogen, fluorine, chlorine or bromine, R is hydrogen, (C₁-C₆)alkyl or (C₂-C₅)alkenyl, and R′ is unsubstituted or substituted (C₃-C₈)alkyl, unsubstituted or substituted (C₂-C₆)alkenyl, (C₃-C₆)cycloalkyl or (C₁-C₃)alkyl(C₃-C₆)cycloalkyl wherein the alkyl and alkenyl substituents are one to three halogens, and derivatives, their enantiomorphs, acid addition salts and metal salt complexes are active broad-spectrum systemic fungicides effective in controlling phytopathogenic fungi such as barley helminthosporium, cucumber downy mildew, cucumber powdery mildew, grape downy mildew, peanut cercospora, rice blast, wheat powdery mildew and wheat stem rust. The compounds have protective and curative activity against rice blast when applied foliarly or systemically and residual activity against rice blast via foliar application.

Abstract translation: 式（ⅩⅤ）的α-（2-烷氧基苯基）-α-烷基-1H-1,2,4-三唑-1-丙腈其中X为氢，氟，氯或溴，R为氢，（ C1-C6）烷基或（C2-C5）烯基，Rmin是未取代或取代的（C3-C8）烷基，未取代或取代的（C2-C6）烯基，（C3-C6）环烷基或（C1-C3） （C3-C6）环烷基，其中烷基和烯基取代基是一至三个卤素，衍生物，它们的对映体，酸加成盐和金属盐络合物是有效的广谱系统杀真菌剂，其有效控制植物病原真菌如大麦helminthosporium，黄瓜枯萎病 霉变，黄瓜白粉病，葡萄霜霉病，花生孢子虫，稻瘟病，小麦白粉病和小麦茎锈病。 当通过叶面施用叶面或全身施用和对稻瘟病的残留活性时，这些化合物对稻瘟病具有保护和治疗活性。

公开(公告)号：EP1026151A1

公开(公告)日：2000-08-09

申请号：EP00300233.4

申请日：2000-01-14

Applicant: ROHM AND HAAS COMPANY

Inventor： Ross, Ronald ,  Nguyen, Duyan Vuong ,  Shaber, Steven Howard

IPC: C07C251/60 ,  C07C251/58 ,  C07C251/42 ,  A01N37/50 ,  A01N33/24 ,  C07D213/53 ,  C07D333/22 ,  A01N43/10 ,  A01N43/40 ,  A01N43/00

CPC classification number: C07D213/53 ,  A01N37/36 ,  A01N37/38 ,  A01N37/50 ,  A01N43/06 ,  A01N43/40 ,  C07C251/60 ,  C07C2601/02 ,  C07D215/12 ,  C07D239/26 ,  C07D241/12 ,  C07D307/52 ,  C07D333/22

Abstract: Compounds with fungicidal and insecticidal properties having formula


wherein X is N or CH; Z is O, S or NR 8 ; A is hydrogen, halo, cyano, (C 1 -C 12 )alkyl, or (C 1 -C 12 )alkoxy; R 1 and R 8 are independently hydrogen or (C 1 -C 4 )alkyl; R 2 is hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, hererocyclic, hererocyclic(C 1 -C 4 )alkyl or C(R 10 )=N-OR 9 ; R 3 is hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, aryl(C 3 -C 7 )cycloalkyl, heterocyclic or heterocyclic(C 1 -C 4 )alkyl; R 4 and R 5 are independently hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, halo, cyano, (C 1 -C 4 )alkoxycarbonyl, aryl, aralkyl, aryl(C 3 -C 7 )cycloalkyl, heterocyclic or hererocyclic(C 1 -C 4 )alkyl; R 6 is hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, halo, cyano, (C 1 -C 4 )alkoxycarbonyl, aryl, aralkyl, aryl(C 3 -C 7 )cycloalkyl, heterocyclic or hererocyclic(C 1 -C 4 )alkyl; R 7 is aryl, aralkyl, heterocyclic or heterocyclic(C 1 -C 4 )alkyl; R 9 is hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, (C 1 -C 4 )alkylcarbonyl, (C 1 -C 4 )alkoxycarbonyl, aryl, or aralkyl; and R 10 is hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic(C 1 -C 4 )alkyl.

公开(公告)号：EP1024135A1

公开(公告)日：2000-08-02

申请号：EP00300232.6

申请日：2000-01-14

Applicant: ROHM AND HAAS COMPANY

Inventor： Ross, Ronald ,  Nguyen, Duyan Vuong ,  Shaber, Steven Howard

IPC: C07C251/60 ,  C07C251/52 ,  C07C251/54 ,  A01N53/00

CPC classification number: A01N37/50 ,  A01N37/36 ,  C07C251/60 ,  C07C2601/02

Abstract: Compounds with fungicidal and insecticidal properties having formula:
   wherein X is N or CH; Y is O, S, or NR 7 ; A is selected from the group consisting of hydrogen, halo, cyano, (C 1 -C 12 )alkyl, and (C 1 -C 12 )alkoxy; R 1 and R 8 are each independently selected from the group consisting of hydrogen, and (C 1 -C 4 )alkyl; R 2 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic, heterocyclic(C 1 -C 4 )alkyl, and C(R 10 )=N-OR 9 ; R 3 is selected from the group consisting of aryl, aralkyl, heterocyclic and heterocyclic(C 1 -C 4 )alkyl; R 4 and R 5 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, halo, cyano, and (C 1 -C 4 )alkoxycarbonyl; R 6 and R 7 are each independently selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, (C 1 -C 4 )alkoxy(C 1 -C 12 )alkyl, halo(C 1 -C 4 )alkoxy(C 1 -C 12 )alkyl, (C 1 -C 4 )alkoxy(C 2 -C 8 )alkenyl, and halo(C 1 -C 4 )alkoxy(C 2 -C 8 )alkenyl; R 9 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, (C 1 -C 4 )alkylcarbonyl, (C 1 -C 4 )alkoxycarbonyl, aryl, and aralkyl; and R 10 is selected from the group consisting of hydrogen, (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 3 -C 7 )cycloalkyl, halo(C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic, and heterocyclic(C 1 -C 4 )alkyl.

Abstract translation: 具有杀真菌和杀虫性质的具有下式的化合物：其中X是N或CH; Y是O，S或NR 7; A选自氢，卤素，氰基，（C 1 -C 12）烷基和（C 1 -C 12）烷氧基; R 1和R 8各自独立地选自氢和（C 1 -C 4）烷基; R2为选自氢，（C1-C12）烷基，卤代（C1-C12）烷基，（C3-C7）环烷基，卤代（C3-C7）环烷基，（C2-C8）烯基，卤代 -C 8）烯基，（C 2 -C 8）炔基，卤代（C 2 -C 8）炔基，芳基，芳烷基，杂环，杂环（C 1 -C 4）烷基和C（R 10）= N-OR 9; R 3选自芳基，芳烷基，杂环和杂环（C 1 -C 4）烷基; R4和R5各自独立地选自氢，（C1-C12）烷基，卤代（C1-C12）烷基，（C3-C7）环烷基，卤代（C3-C7）环烷基，（C2-C8）烯基 ，（C 2 -C 8）炔基，卤代（C 2 -C 8）炔基，卤素，氰基和（C 1 -C 4）烷氧基羰基; R6和R7各自独立地选自氢，（C1-C12）烷基，卤代（C1-C12）烷基，（C3-C7）环烷基，卤代（C3-C7）环烷基，（C2-C8）烯基 卤代（C 2 -C 8）炔基，卤代（C 2 -C 8）炔基，（C 1 -C 4）烷氧基（C 1 -C 12）烷基，卤代（C 1 -C 4） ，（C 1 -C 4）烷氧基（C 2 -C 8）烯基和卤代（C 1 -C 4）烷氧基（C 2 -C 8）烯基; R9为选自氢，（C1-C12）烷基，卤代（C1-C12）烷基，（C2-C8）烯基，卤代（C2-C8）烯基，（C2-C8）炔基，卤代 -C 8）炔基，（C 1 -C 4）烷基羰基，（C 1 -C 4）烷氧基羰基，芳基和芳烷基; 并且R 10选自氢，（C 1 -C 12）烷基，卤代（C 1 -C 12）烷基，（C 3 -C 7）环烷基，卤代（C 3 -C 7）环烷基，（C 2 -C 8）烯基，卤代（ C 2 -C 8）烯基，（C 2 -C 8）炔基，卤代（C 2 -C 8）炔基，芳基，芳烷基，杂环和杂环（C 1 -C 4）烷基。

公开(公告)号：EP0936213A1

公开(公告)日：1999-08-18

申请号：EP99300573.5

申请日：1999-01-26

Applicant: ROHM AND HAAS COMPANY

Inventor： Lixin, Zhang ,  Zongcheng, Li ,  Zhinian, Li ,  Hong, Zhang ,  Changling, Liu ,  Bin, Li ,  Shaber, Steven Howard

IPC: C07C251/60 ,  A01N33/24 ,  C07D307/52 ,  C07D213/53 ,  A01N43/08 ,  A01N43/40

CPC classification number: C07D213/53 ,  A01N37/36 ,  A01N37/50 ,  A01N43/40 ,  C07C251/60 ,  C07D307/52

Abstract: Compounds with fungicidal and insecticidal properties having formula
wherein X is N or CH; Y is O, S or NR 6 ;

A is independently hydrogen, halo, cyano, (C 1 -C 12 )alkyl, or (C 1 -C 12 )alkoxy;
R 1 and R 6 is independently hydrogen or (C 1 -C 4 )alkyl;
R 2 is independently hydrogen, (C 1 -C 12 )alkyl, halo(C 1- C 12 )alkyl, (C 3 -C 7 )cycloalkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, halo(C 2 -C 8 )alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic(C 1 -C 4 )alkyl;
R 3 is independently hydrogen or (C 1 -C 4 )alkyl;
R 4 and R 5 is independently hydrogen, (C 1 -C 4 )alkyl, aryl, aralkyl, aryl(C 2 -C 8 )alkenyl, aryl(C 2 -C 8 )alkynyl, heterocyclic, or heterocyclic(C 1 -C 4 )alkyl wherein if one of R 4 and R 5 is hydrogen or (C 1 -C 4 )alkyl than the other of R 4 and R 5 is other than hydrogen or (C 1 -C 4 )alkyl,
   and its enantiomers and stereoisomers and agronomically acceptable salts.

Abstract translation: 具有杀菌和杀虫性质的具有式CHEM的化合物，其中X是N或CH; Y是O，S或NR6; A独立地是氢，卤素，氰基，（C 1 -C 12）烷基或（C 1 -C 12）烷氧基; R1和R6独立地是氢或（C1-C4）烷基; （C 1 -C 12）烷基，（C 3 -C 7）环烷基，（C 2 -C 8）烯基，卤代（C 2 -C 8）烯基，（C 2 -C 8）炔基，卤代 （C 2 -C 8）炔基，芳基，芳烷基，杂环或杂环（C 1 -C 4）烷基; R3独立地为氢或（C1-C4）烷基; R4和R5独立地是氢，（C1-C4）烷基，芳基，芳烷基，芳基（C2-C8）烯基，芳基（C2-C8）炔基，杂环或杂环（C1-C4）烷基，其中如果R4和 R 5是氢或（C 1 -C 4）烷基，而R 4和R 5不是氢或（C 1 -C 4）烷基，其对映异构体和立体异构体和农艺学上可接受的盐。

公开(公告)号：EP0919545A2

公开(公告)日：1999-06-02

申请号：EP98309234.7

申请日：1998-11-11

Applicant: ROHM AND HAAS COMPANY

Inventor： Ross, Ronald ,  Fujimoto, Ted Tsutomo ,  Szapacs, Edward Michael ,  Shaber, Steven Howard

IPC: C07C271/28 ,  C07D213/50 ,  C07D239/26 ,  C07D333/22 ,  A01N47/24

CPC classification number: C07D239/26 ,  A01N47/24 ,  C07C271/28 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/50 ,  C07D333/22

Abstract: Compounds with fungicidal properties having formula I
where m and n are 0 or 1 provided that m + n is 1; X is hydrogen, halo, (C 1 -C 4 )alkyl, or (C 1 -C 4 )alkoxy; R is an optionally-substituted alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, aryl, aralkyl, or heterocyclic group; R 1 and R 2 are hydrogen, optionally-substituted alkyl, cycloalkyl, cyano, carboxy alkyl, or aryl; at least one of R 1 and R 2 is hydrogen; and R 3 is alkyl or haloalkyl.

公开(公告)号：EP0572191B1

公开(公告)日：1996-09-04

申请号：EP93303988.5

申请日：1993-05-21

Applicant: ROHM AND HAAS COMPANY

Inventor： Hsu, Adam Chi-Tung ,  Shaber, Steven Howard ,  Michelotti, Enrique Luis

IPC: C07D233/72 ,  C07D233/74 ,  A01N43/50

CPC classification number: C07D235/02 ,  A01N43/50 ,  C07D233/72 ,  C07D233/74

公开(公告)号：EP0672672A2

公开(公告)日：1995-09-20

申请号：EP95301711.8

申请日：1995-03-15

Applicant: ROHM AND HAAS COMPANY

Inventor： Shaber, Steven Howard ,  Reynolds, Charles Howard ,  Szapacs, Edward Michael

IPC: C07F7/08 ,  A01N55/00 ,  C07F7/18

CPC classification number: A01N55/00 ,  C07F7/0812 ,  C07F7/0814 ,  C07F7/18

Abstract: The present invention provides fungicidal heterocyclic silyl compounds of the general formula
wherein Het is a six membered heterocyclic moiety ; R is hydrogen or a trisubstituted silyl group ; R 1 , R 2 and R 3 are independently selected from substituted or unsubstituted alkyl, alkenyl, alkynyl, alkoxy, phenyl, benzyl and phenethyl groups ; m is 0 or 1 ; and n is zero, one or two.

Abstract translation: 本发明提供通式的杀真菌杂环甲硅烷基化合物，其中Het是六元杂环部分; R是氢或三取代的甲硅烷基; R 1，R 2和R 3独立地选自取代或未取代的烷基，烯基，炔基，烷氧基，苯基，苄基和苯乙基; m为0或1; n为零，一或二。

公开(公告)号：EP0576201A2

公开(公告)日：1993-12-29

申请号：EP93304697.1

申请日：1993-06-16

Applicant: ROHM AND HAAS COMPANY

Inventor： Shaber, Steven Howard ,  Nguyen, Luong Tu

IPC: C07D249/08 ,  C07D401/12 ,  C07D405/12 ,  C07D403/12 ,  C07F7/18 ,  C07F9/06 ,  A01N43/653

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07F7/1856 ,  C07F9/65181

Abstract: 2-Aryl or 2-heterocyclyl-2, 2-disubstituted ethyl-1,2,4-triazoles have been shown to have fungicidal activity. They have the formula

wherein X is (C₆-C₁₀)aryl optionally substituted with up to three substituents, preferably with up to two substituents, which are independently hydroxy, halo, acetoxy, trihalomethyl, (C₁-C₄)alkyl, (C₁-C₄) alkoxy, (C₁-C₄)alkylthio, (C₁-C₄)alkylsulfinyl, (C₁-C₄)alkylsulfonyl, (C₁-C₄)-alkoxy(C₁-C₄)alkoxy, (C₁-C₄)alkylcarbonyl, (C₂-C₄)alkynyloxy, (C₂-C₈)alkenyl, (C₂-C₄)-alkenyloxy, (C₂-C₈)alkynyl, phenyl optionally monosubstituted with halo, alkyl or alkoxy, phenoxy optionally monosubstituted with halo, alkyl or alkoxy; or X is a 5 and 6 membered heterocyclic ring having up to three heteroatoms which are independently nitrogen, oxygen or sulfur, optionally substituted with up to two of (C₁-C₄)alkyl and/or halo,
   Q is 1-(1,2,4-triazolyl) or 4-(1,2,4-triazolyl) each optionally substituted with up to two substituents which are independently halo, (C₁-C₄)alkyl, nitro, cyano, mercapto or (C₁-C₅)alkylmercapto;
   Z is (C₁-C₁₂)alkyl, halo(C₁-C₁₂)alkyl, (C₂-C₈)alkenyl, halo(C₂-C₈)alkenyl, (C₂-C₈)alkynyl, (C₃-C₈)cycloalkyl, (C₅-C₈)cycloalkenyl, (C₃-C₈)cycloalkyl(C₁-C₆)alkyl, (C₆-C₁₀)aryl, (C₇-C₁₁)aralkyl, heterocyclyl as defined above for X or heterocyclyl(C₁-C₆)alkyl, provided X and Z are not both heterocyclyl groups;
   W is -OR, -OCOR'', -OCOY, -OCOR'Y, -OCOR'OR'', -OR'OCOR'', -OR'OR, -NH₂, -NHCOR, -NHCOR'Y, -NHCOY, -OCONHY, -OSO₂A, -OSiA₃, -OPO(OA)₂ or halo, wherein
   A is (C₁-C₆)alkyl;
   R is (C₁-C₁₂)alkyl, X, Y-alkyl, (C₃-C₈)alkenyl, (C₃-C₈)alkynyl, (C₃-C₈)cycloalkyl, cyano(C₁-C₆)alkyl or epoxy(C₁-C₆)alkyl, all optionally halogenated, or is hydrogen, provided that when Z is methyl, R is not haloalkyl;
   R' is (-CH(CH₃)-) p (-CH₂-) m or (-CH₂-),CH=CH(-CH₂-) t ;
   m is an integer from 0 to 6;
   p is 0 or 1, provided m and p are not both 0;
   s and t are each independently integers of from 0 to 3;
   R'' is (C₁-C₂)-trialkylsilyl(C₁-C₄)alkyl, phenyl, (C₁-C₆)alkyl or (C₂-C₄)alkenyl, all optionally halogenated, or is hydrogen;
   R''' is hydrogen or (C₁-C₆)alkyl;
   n is an integer from 1 to 6; and
   Y is phenyl, naphthyl, piperidinyl, triazolyl, pyrazinyl, pyrimidinyl, phthalimido, morpholinyl, pyridyl, thienyl, furyl or (C₃-C₈)cycloalkyl, all optionally substituted with the substituents defined for X.

Abstract translation: 已显示2-芳基或2-杂环基-2,2-二取代的乙基-1,2,4-三唑具有杀真菌活性。 它们具有下式：其中X是任选被至多三个取代基取代的（C 6 -C 10）芳基，优选具有至多两个独立地为羟基，卤素，乙酰氧基，三卤甲基，（C 1 -C 4）烷基，（C 1 -C 4） ）C 1 -C 4烷硫基，C 1 -C 4烷基亚磺酰基，（C 1 -C 4）烷基磺酰基，（C 1 -C 4）烷氧基，（C 1 -C 4）烷氧羰基，（C 2 -C 4） 炔基氧基，（C 2 -C 8）烯基，（C 2 -C 4）烯基氧基，（C 2 -C 8）炔基，用卤素任选单取代的苯基，烷基或烷氧基，用卤素，烷基或烷氧基任意单取代的苯氧基; 或X是具有至多三个独立地为氮，氧或硫的杂原子的5和6元杂环，其任选被至多两个（C 1 -C 4）烷基和/或卤素取代，Q为1-（1,2 （C 1 -C 4）烷基，硝基，氰基，巯基或（C 1 -C 5）烷基巯基的至多两个取代基取代的4-（1,2,4-三唑基）或4-（1,2,4-三唑基） （C 1 -C 12）烷基，卤代（C 1 -C 12）烷基，（C 2 -C 8）烯基，卤代（C 2 -C 8）链烯基，（C 2 -C 8）炔基，（C 3 -C 8）环烷基，（C 5 -C 8） ）环烯基，（C 3 -C 8）环烷基（C 1 -C 6）烷基，（C 6 -C 10）芳基，（C 7 -C 11）芳烷基，X如上定义的杂环基或杂环基（C 1 -C 6） 不是两个杂环基团; W是-OR，-OCOR“，-OCOY，-OCOR'Y，-OCOR'OR”，-OR'OCOR“， - OR'OR，-NH 2，-NHCOR，-NHCOR'Y，-NHCOY ，-OCONHY，-OSO 2 A，-OSiA 3，-OPO（OA）2或卤素，其中A是（C 1 -C 6）烷基; （C 1 -C 12）烷基，X，Y-烷基，（C 3 -C 8）链烯基，（C 3 -C 8）炔基，（C 3 -C 8）环烷基，氰基（C 1 -C 6）烷基或环氧（C 1 -C 6） 烷基，全部任选被卤代，或者是氢，条件是当Z是甲基时，R不是卤代烷基; （-CH（CH 3） - ）p（-CH 2 - ）m或（-CH 2 - ），CH = CH（-CH 2 - ）t; m是0至6的整数; p是0或1，只要m和p不都是0; s和t各自独立地为0至3的整数; （C 1 -C 2） - 三烷基甲硅烷基（C 1 -C 4）烷基，苯基，（C 1 -C 6）烷基或（C 2 -C 4）烯基，它们全部任选被卤代或是氢; R''是氢或（C 1 -C 6）烷基; n是1至6的整数; Y是苯基，萘基，哌啶基，三唑基，吡嗪基，嘧啶基，邻苯二甲酰亚氨基，吗啉基，吡啶基，噻吩基，呋喃基或（C 3 -C 8）环烷基，它们全部任选被定义为X的取代基取代。