公开(公告)号：JPH11302236A

公开(公告)日：1999-11-02

申请号：JP20881998

申请日：1998-07-24

Applicant: SAGAMI CHEM RES

Inventor： SODEOKA MIKIKO ,  HAGIWARA EMIKO ,  FUJII AKIO

IPC: B01J31/22 ,  C07B53/00 ,  C07B61/00 ,  C07C221/00 ,  C07C225/06 ,  C07C227/18 ,  C07C229/18 ,  C07C229/60 ,  C07C303/36 ,  C07C311/16 ,  C07F15/00

Abstract: PROBLEM TO BE SOLVED: To efficiently synthesize the subject compounds useful as an intermediate for producing medicines, etc., by reacting a silyl enol ether with an imine in the presence of a specific catalyst. SOLUTION: A silyl enol ether represented by formula I [R is a substituted silyl; R is a (substituted) alkyl, a (substitute) alkenyl or the like; R and R are each H, a (substituted) alkyl, a (substituted) alkenyl or the like] is reacted with an imine represented by formula II [R is a (substituted) alkyl, a (substituted) alkenyl or the like; R is H, a (substituted) alkyl, a (substituted) alkenyl or the like] in the presence of a catalyst comprising a palladium- optically active phosphine ligand to afford the objective compounds represented by formula III. In the above reaction, e.g. N,N-dimethylformamide is preferably used as a solvent and the reaction is preferably carried out in the presence of a base such as calcium carbonate at a reactional temperature within the range of ambient temperature to 70 deg.C.